Abstract: The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency.

Abstract: The present invention relates to oligonucleotides (oligomers) that are complementary to voltage-gated sodium ion channel encoding nucleic acids, such as SCN9A, which encodes the voltage-gated sodium channel Nav1.7. The oligonucleotides of the invention are capable of inhibiting the expression of voltage-gated sodium ion channels, such as Nav1.7, and are useful in the prevention or the treatment of pain.

Abstract: Enhanced antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1), leading to modulation of the expression of RTEL1 or modulation of RTEL1 activity are provided. This disclosure relates to the use of enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. This disclosure further relates to the use of the enhanced antisense oligonucleotides targeting RTEL1 for destabilizing cccDNA, such as HBV cccDNA. A pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection is also described.

Abstract: A computer-implemented method for creating an encoder-decoder system for embedding information in a decorative label. The method includes defining a family of encoder functions and a family of decoder functions. Each encoder function of the family of encoder functions configured to encode information as a respective modification of a decorative label. Each decoder function of the family of decoder functions configured to decode an image of a modified decorative label into respective decoded information. The method includes applying an iterative optimization process to determine an optimized encoder-decoder pair. The optimized encoder-decoder air includes an optimized encoder function and an optimized decoder function. The optimized encoder function is selected by the iterative optimization process from the family of encoder functions and the optimized decoder function is selected by the iterative optimization process from the family of decoder functions.

Abstract: The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency.

Abstract: The present invention relates to oligonucleotides (oligomers) that are complementary to voltage-gated sodium ion channel encoding nucleic acids, such as SCN9A, which encodes the voltage-gated sodium channel Nav1.7. The oligonucleotides of the invention are capable of inhibiting the expression of voltage-gated sodium ion channels, such as Nav1.7, and are useful in the prevention or the treatment of pain.

Abstract: The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.

Abstract: The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.

Abstract: The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.

Abstract: The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.

Abstract: The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.

Abstract: The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

Abstract: The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

Abstract: The present invention relates to isolated polypeptides having phytase activity, recombinant DNA sequences encoding such polypeptides, methods of producing such polypeptides, and the use of the polypeptides in transgenic plants. The invention discloses polypeptides having affinity for the substrate phytate (1, 2, 3, 4, 5, 6 myo-inositol-hexakisphosphate, phytic acid), comprising an amino acid sequence as described by the invention. Furthermore, the invention discloses DNA fragments encoding the polypeptides, and cDNA fragments encoding the polypeptides. The polypeptides of the invention may, for example, be used as an additive in animal feeds, an additive in food for human consumption, or to extract proteins from rice bran. The invention also concerns a transgenic plant or part thereof, wherein the plant or part thereof has been genetically modified to comprise a polypeptide as defined by the invention.

Abstract: The invention relates to an automatic fault diagnostic procedure for machines, such as steam, gas and hydro-turbines, generators, pumps, electrical motors, etc. For each of a plurality of components, for each of a number of possible faults, a total fault symptom strength value is calculated from measured data. If the value is above a predetermined value, the fault symptom strength is plotted and fitted to a trend line to determine an estimate of when the fault symptom strength will exceed a predetermined value. Output messages are then selected based on the fit.

Abstract: The invention relates to a punched out sheet for use in making a bird-nesting box without using tools or other aids and to a bird nesting box made from the same. The sheet has an interconnected outer part and an inner punch-out part. The outersheet has a carrier handle and devices for adjustment and reinforcement of the entrance and exit hole of the box. The inner part has bipartite suspension devices, a surface device in the form of a ladder and a transverse device in the form of a guard against predators.