Abstract: The invention generally relates to systems and methods for targeting of specific tissue(s) of interest in a sino-nasal region of a patient for the treatment of a rhinosinusitis condition. A device of the present invention includes an end effector including one or more flexible printed circuit board (PCB) members for delivering energy to one or more target sites within the sino-nasal cavity of the patient while minimizing or avoiding collateral damage to surrounding or adjacent non-targeted tissue, such as blood vessels, bone, and nontargeted neural tissue.