Patents by Inventor Sohail Tavazoie

Sohail Tavazoie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment and diagnosis of melanoma
    Patent number: 11865094
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: January 9, 2024
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nora Pencheva
  • METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
    Publication number: 20230338314
    Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.
    Type: Application
    Filed: May 3, 2023
    Publication date: October 26, 2023
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Masoud Tavazoie
  • Methods for the treatment of myeloid derived suppressor cells related disorders
    Patent number: 11648220
    Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: May 16, 2023
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Masoud Tavazoie
  • COMPOSITIONS AND METHODS TO TREAT METASTATIC GASTROINTESTINAL CANCER
    Publication number: 20220339184
    Abstract: The present invention relates to agents and methods for treating gastrointestinal cancer (e.g., metastatic colorectal cancer) in a subject in need thereof. The method includes suppressing the enzymatic activity of DHODH and/or decreasing the level of creatine via suppression of creatine transporter channel SLC6a8 in the subject. In some embodiments, the suppression step can be carried out by administering to the subject a set of small molecule compounds.
    Type: Application
    Filed: September 25, 2020
    Publication date: October 27, 2022
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Norihiro Yamaguchi, Kivanc Birsoy
  • APOE GENOTYPING IN CANCER PROGNOSTICS AND TREATMENT
    Publication number: 20220127680
    Abstract: This disclosure presents methods and reagents for cancer prognosis and treatment based on APOE genotyping. Specifically, the presence of the APOE2 genotype is indicative of a poor prognosis for the subject, whereas the presence of the APOE4 genotype is indicative of a good prognosis for the subject. The disclosed methods and reagents are useful for treating cancer and for making medical and clinical decisions on adjuvant therapy, tumor surveillance, and the likelihood of disease progression.
    Type: Application
    Filed: February 28, 2020
    Publication date: April 28, 2022
    Applicant: The Rockefeller Universtiy
    Inventors: Sohail Tavazoie, Benjamin N. Ostendorf, Masoud Tavazoie, Foster Gonsalves
  • Anti-MERTK agonistic antibodies and uses thereof
    Patent number: 11225524
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: January 18, 2022
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • TREATMENT AND DIAGNOSIS OF MELANOMA
    Publication number: 20210220306
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: March 15, 2021
    Publication date: July 22, 2021
    Inventors: Sohail Tavazoie, Nora Pencheva
  • TREATMENT OF ANGIOGENESIS DISORDERS
    Publication number: 20210139997
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Application
    Filed: January 4, 2021
    Publication date: May 13, 2021
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png
  • Treatment of angiogenesis disorders
    Patent number: 10894989
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: January 19, 2021
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png
  • TREATMENT OF ANGIOGENESIS DISORDERS
    Publication number: 20190352722
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 21, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png
  • ANTI-MERTK AGONISTIC ANTIBODIES AND USES THEREOF
    Publication number: 20190241676
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Application
    Filed: January 24, 2019
    Publication date: August 8, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • tRNA quantification
    Patent number: 10337065
    Abstract: In one embodiment, the present invention relates to a method for optimizing cell-type specific protein expression. In another embodiment, the present invention relates to a method for creating a tRNA profile of a cell.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: July 2, 2019
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Sohail Tavazoie, Hani Goodarzi
  • Treatment of angiogenesis disorders
    Patent number: 10301684
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: May 28, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png
  • TREATMENT AND DIAGNOSIS OF COLON CANCER
    Publication number: 20190125706
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 2, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • Anti-MERTK agonistic antibodies and uses thereof
    Patent number: 10221248
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: March 5, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
    Publication number: 20190029984
    Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 31, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Masoud Tavazoie
  • Treatment and diagnosis of colon cancer
    Patent number: 10172817
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: January 8, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • TREATMENT AND DIAGNOSIS OF COLON CANCER
    Publication number: 20190000788
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: June 22, 2017
    Publication date: January 3, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • ANTI-MERTK AGONISTIC ANTIBODIES AND USES THEREOF
    Publication number: 20180002444
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Application
    Filed: December 21, 2015
    Publication date: January 4, 2018
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • TREATMENT OF ANGIOGENESIS DISORDERS
    Publication number: 20170362664
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 21, 2017
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png