Patents by Inventor Soheil AKBARI

Soheil AKBARI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LONG-TERM AND FUNCTIONAL CULTURE OF HEPATIC ORGANOIDS (eHEPO) DERIVED FROM EPCAM+ ENDODERMAL PROGENITOR CELLS DIFFERENTIATED FROM INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20230392122
    Abstract: A three-dimensional (3D) liver organoid obtained through the differentiation of induced pluripotent stem cells (IPSCs) in laboratory culture medium and a production method of the 3D hepatic organoid are provided. The production method includes the following steps: differentiating the IPSCs into a definitive endoderm in a medium containing Activin A, Wnt3a, and R-spo1 factors; adding 5 ng/ml R-spo 1 during IPSC differentiation to increase an amount of EpCAM+endoderm progenitor cells; cell sorting of the EpCAM+endoderm progenitor cells through a fluorescence-activated cell sorting (FACS) method; culturing a sorted EpCAM+endoderm progenitor cells in a 3D Matrigel medium of 37° C., 5% CO2, 95% humidity and 7.2-7.5 pH.
    Type: Application
    Filed: August 2, 2021
    Publication date: December 7, 2023
    Applicants: DOKUZ EYLUL UNIVERSITESI REKTORLUGU, IZMIR BIYOTIP VE GENOM MERKEZI, KOC UNIVERSITESI
    Inventors: Serife Esra ERDAL BAGRIYANIK, Soheil AKBARI, Tevfik Tamer ONDER, Nur ARSLAN