Abstract: A cell culture system for fermentation or cultivation of at least one of cells, tissues or tissue-like cell cultures, organs or organ-like cell cultures and multicellular organisms comprises: a system vessel (1) in which at least one cavity (6) is formed, the cavity (6) having at least three ports (2, 3, 4); at least one porous substrate (9) installed within the cavity (6) so as to allow fluid flowing from any one to any other of said three ports (2, 3, 4) to pass through said porous substrate (9); and, at least one channel extending from a first one of said ports (3) within the porous substrate (9) towards a central region of said porous substrate (9).

Abstract: A cell culture system for fermentation or cultivation of at least one of cells, tissues or tissue-like cell cultures, organs or organ-like cell cultures and multicellular organisms comprises: a system vessel (1) in which at least one cavity (6) is formed, the cavity (6) having at least three ports (2, 3, 4); at least one porous substrate (9) installed within the cavity (6) so as to allow fluid flowing from any one to any other of said three ports (2, 3, 4) to pass through said porous substrate (9); and, at least one channel extending from a first one of said ports (3) within the porous substrate (9) towards a central region of said porous substrate (9).

Abstract: The present invention relates to a process of producing composite materials by a sol/gel-process, comprising carbon nanoparticles and organic polymer material. The invention further relates to composite materials, which are manufactured with the use of said sol/gel technology.

Abstract: Exemplary embodiments of the present invention relate to an implant, e.g., a stent, and in particular to a stent having at least one section made of a material having a particular porous structure.

Abstract: A high-frequency spray device is provided that is suitable for applying a coating fluid onto a substrate. The spray device can include an atomizing arrangement, a movable substrate holder, a gas supply, and one or more temperature control elements. The atomizing arrangement can include a resonance body which may have a trumpet-like shape and which can be excited to produce high-frequency vibrations that may provide a spray mist jet of the coating fluid. The spray device can further include a field arrangement capable of generating an electric and/or magnetic field in the region containing the substrate which may influence the deposition of the spray mist jet on the substrate. The spray device may also include a suction arrangement that can affect the shape of the spray jet mist and/or withdraw a portion of the spray jet mist.

Abstract: The exemplary embodiments of the present invention relates to a curable therapeutic implant composition for use in the filling of a cavity in a living organism, comprising particles of a metallic material, and a curable matrix-forming, non-particulate material, wherein at least one of the metallic material or the matrix-forming material is at least partially degradable in-vivo. Furthermore, the exemplary embodiments of the present invention relate to methods of filling a cavity in a living organism with the use of the curable implant composition.

Abstract: The exemplary embodiments of the present invention relate to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a matrix forming an open-celled structure having a plurality of interconnected spaces, whereas the channels of the matrix are substantially completely filled with metallic material particles, and wherein at least one of the metallic material or the matrix material is at least partially degradable in-vivo. Furthermore, the present invention relates to a method for repairing a bone or cartilage defect in a living organism, comprising implanting an implant according to the exemplary embodiments of the present invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially.

Abstract: Exemplary embodiment of the present invention is directed to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a three-dimensional open-celled framework structure made of a non-particulate first material, the framework structure being embedded in a second, non-particulate material different from said first material, or the open-celled framework structure being substantially completely filled with said second, non-particulate material, wherein at least one of the first material or the second material is at least partially degradable in-vivo. Furthermore, the present invention is directed to a method for repairing a bone or cartilage defect in a living organism, comprising implanting an implant according to the exemplary embodiment of the present invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially.

Abstract: The exemplary embodiment of the present invention are provided which relate to porous implants and methods for manufacture thereof which use powder molding techniques. For example, a suspension can be provided comprising a plurality of first particles of at least one organic polymer, a plurality of second particles of at least one metal-based material, and at least one solvent. The first and second particles can be substantially insoluble in the solvent. The suspension can be molded to form a green body comprising the first particles embedded in a matrix of compressed second particles. The first particles may be removed from the green body by thermally induced decomposition and/or evaporation. The green body can be sintered to form the implant. The removals of the first particles can be performed during sintering.

Abstract: An exemplary embodiment of a reversibly closable vessel suitable for the cultivation of cells and/or tissues can be provided. The exemplary vessel can comprise at least one reversibly closable aperture in the vessel wall, a convection arrangement inside the vessel which can comprise at least one blade. The arrangement can be configured to generate and/or modulate a convection in a fluid within the vessel when the vessel and/or the blade is agitated The convection arrangement and/or the blade can be at least particularly made from a porous material.

Abstract: An exemplary embodiment of a culture vessel suitable is provided for a cultivation of cells and/or tissues. The exemplary vessel comprising at least one reversibly closable aperture in the vessel wall, and at least one surface-increasing substrate within the vessel, with the substrate being made of a single mold. According to another exemplary embodiment, a system can be provided comprising at least two vessels being interconnected via at least one aperture in their vessel wall, and a cultivation process using such a vessel or system, in which at least one type of cells, tissue, tissue-like cell cultures, organs, organ-like cell cultures, or multicellular organisms may be cultivated in the presence of at least one fluid or solid medium, e.g., provided for growing and/or cultivating the culture.

Abstract: An exemplary embodiment of a reversibly closable vessel suitable for the cultivation of cells and/or tissues can be provided. The exemplary vessel can comprise at least one reversibly closable aperture in the vessel wall, at least one wall provided in the interior of the vessel, with the wall being an integral part of the vessel. The interior can be divided into at least two compartments, whereas the wall comprises at least one of a hole, tube-like hole, opening, or a partially porous structure, which facilitates the flow of fluids from one compartment to another. At least one of the compartments can comprise at least one filler.

Abstract: An exemplary embodiment of a reversibly closable bag suitable for the cultivation of cells and/or tissues can be provided. The exemplary bag can comprise at least one reversibly closable aperture in the bag wall, and a surface-increasing convection arrangement inside the bag. The convection arrangement is capable to generate and/or modify a convection in a fluid within said bag when at least one of the fluid, the bag, and the convection arrangement is agitated. For example, the surface increasing convection arrangement can be at least one blade, at least one particulate filler and/or at least one surface-increasing substrate being made of a single mould.

Abstract: Exemplary embodiments of the present invention relate to a stent having a supporting structure of a non-particulate inorganic carbon material.

Abstract: Exemplary embodiments of the present invention of a stent are provided, e.g., at least partially biodegradable stent which can have at least one section made of a material having a particular porous structure.

Abstract: An exemplary embodiment of a process can be provided for a manufacture of an implantable medical device or a part thereof. For example, at least one metallic layer can be deposited on a three-dimensional template of the device and at least partially removing the template. Implants can be produced, e.g., which may have relatively large reservoirs for including an active ingredient, such as a pharmacologically, therapeutically or biologically active agent, a diagnostically active agent, a marker, an absorptive agent, for eluting in-vivo.

Abstract: Exemplary embodiments of the present invention related to medical implants, such as e.g. stents are provided. For example, the implant can comprise at least one hollow space or lumen within the structural material or structure of the device, other than a pore or pore system, which may be used as a reservoir for a specific amount of active ingredient to be released after implantation into the body.

Abstract: Exemplary embodiments of the present invention relate to a stent, and in particular to at least partially biodegradable stent having at least one section made of a material having a particular porous structure.

Abstract: An exemplary embodiment of the present invention provides an at least partially biodegradable medical implant having a plurality of in-vivo biodegradable organic polymer particles embedded in a matrix of a plurality of compressed metal-based particles. Methods for the manufacture thereof are also provided. The implant may preferably be further functionalized by inclusion of active ingredients such as therapeutically active agents or markers.

Abstract: The exemplary embodiment of the present invention are provided which relate to at least partially degradable implants and methods for the manufacture thereof which can use powder molding techniques. For example, a suspension can be provided comprising a plurality of first particles of at least one organic polymer, a plurality of second particles of at least one metal-based material which is at least partially biodegradable in-vivo, and at least one solvent. The first and second particles can be substantially insoluble in the solvent. The suspension can be molded to form a green body comprising the first particles embedded in a matrix of compressed second particles. The first particles may be removed from the green body by thermally induced decomposition and/or evaporation. Further, the green body can be sintered to form the implant. The first particles may be removed during the sintering procedure.