Patents by Inventor Soizic le Greneur

Soizic le Greneur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING A CHELATING LIGAND DERIVED FROM PCTA
    Publication number: 20230339945
    Abstract: The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below: involving: i) decomplexation of the complex of formula (II): constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: ii) removing the gadolinium salt formed in step i), for example by filtration, and ii) recovering the free macrocyclic ligand of formula (L). The present invention also relates to a composition comprising the diastereoisomerically enriched complex of formula (II) and the macrocyclic ligand of formula (L).
    Type: Application
    Filed: July 19, 2021
    Publication date: October 26, 2023
    Applicant: GUERBET
    Inventors: Martine CERF, Soizic LE GRENEUR, Alain CHÉNEDÉ, Bruno FRANÇOIS
  • COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED FROM A DIASTEREOISOMERICALLY ENRICHED PCTA AND PREPARATION AND PURIFICATION PROCESS
    Publication number: 20230149568
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
    Type: Application
    Filed: January 16, 2023
    Publication date: May 18, 2023
    Inventors: Soizic LE GRENEUR, Alain CHÉNEDÉ, Martine CERF, Myriam PETTA, Emmanuelle MARAIS, Bruno FRANÇOIS, Caroline ROBIC, Stéphanie LOUGUET
  • Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
    Patent number: 11590246
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: February 28, 2023
    Assignee: GUERBET
    Inventors: Soizic Le Greneur, Alain Chénedé, Martine Cerf, Myriam Petta, Emmanuelle Marais, Bruno François, Caroline Robic, Stéphanie Louguet
  • Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method
    Patent number: 11426470
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: August 30, 2022
    Assignee: GUERBET
    Inventors: Soizic Le Greneur, Alain Chénedé, Martine Cerf, Stéphane Decron, Bruno François
  • Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
    Patent number: 11370804
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: June 28, 2022
    Assignee: GUERBET
    Inventors: Soizic Le Greneur, Alain Chénedé, Martine Cerf, Myriam Petta, Emmanuelle Marais, Bruno François, Caroline Robic, Stéphanie Louguet
  • COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED OF A DIASTEREOISOMERICALLY ENRICHED PCTA AND SYNTHESIS METHOD
    Publication number: 20220098218
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.
    Type: Application
    Filed: January 17, 2020
    Publication date: March 31, 2022
    Inventors: Soizic LE GRENEUR, Alain CHÉNEDÉ, Martine CERF, Stéphane DECRON, Bruno FRANÇOIS
  • COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED FROM A DIASTEREOISOMERICALLY ENRICHED PCTA AND PREPARATION AND PURIFICATION PROCESS
    Publication number: 20220062443
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
    Type: Application
    Filed: January 17, 2020
    Publication date: March 3, 2022
    Inventors: Soizic LE GRENEUR, Alain CHÉNEDÉ, Martine CERF, Myriam PETTA, Emmanuelle MARAIS, Bruno FRANÇOIS, Caroline ROBIC, Stéphanie LOUGUET
  • COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED FROM A DIASTEREOISOMERICALLY ENRICHED PCTA AND PREPARATION AND PURIFICATION PROCESS
    Publication number: 20210371437
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
    Type: Application
    Filed: August 16, 2021
    Publication date: December 2, 2021
    Inventors: Soizic LE GRENEUR, Alain CHÉNEDÉ, Martine CERF, Myriam PETTA, Emmanuelle MARAIS, Bruno FRANÇOIS, Caroline ROBIC, Stéphanie LOUGUET
  • COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED OF A DIASTEREOISOMERICALLY ENRICHED PCTA AND SYNTHESIS METHOD
    Publication number: 20210361782
    Abstract: The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.
    Type: Application
    Filed: August 9, 2021
    Publication date: November 25, 2021
    Inventors: Soizic LE GRENEUR, Alain CHÉNEDÉ, Martine CERF, Stéphane DECRON, Bruno FRANÇOIS
  • Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
    Patent number: 5871713
    Abstract: Biological or synthetic macromolecular polyamine compound. optionally of the dendrimer type, characterized in that it carries at least three radio-opaque iodine-containing derivatives.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: February 16, 1999
    Assignee: Guerbet S.A.
    Inventors: Dominique Meyer, Soizic Le Greneur
  • Polyiodinated compounds, their preparation and their use as contrast media for radiology
    Patent number: 5817873
    Abstract: The present invention relates to polyiodinated compounds with a single molecular weight having a molecular concentration of iodine of greater than approximately 20% by weight, and in particular greater than approximately 30% by weight, containing at least 9 iodine atoms and having a molecular weight above 2000 and below approximately 50,000, and in particular above 2000 and below approximately 20,000, said compounds possessing either a zero overall electrical charge or at least two anionic charges, and persisting in the vascular compartment at a value equal to at least approximately 30% by weight of the injected dose in a subject five minutes after intravascular administration in the said subject.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: October 6, 1998
    Assignee: Guerbet S.A.
    Inventors: Dominique Meyer, Soizic le Greneur, Gael le Lem, Christian Simonot, Catherine Chambon
  • Compounds which can be used in contrast products for radiography
    Patent number: 5609851
    Abstract: Polyiodinated nonionic compound that have the formula: ##STR1##
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: March 11, 1997
    Assignee: Guerbet S A.
    Inventors: Fatima Z. Bennani, Soizic le Greneur, Christian Simonot, Dominique Meyer