Abstract: Provided is a method, whereby weights are assigned to edges in a signal propagation process starting from a node corresponding to a queried entity and directionality of signal propagation is assigned based on the weights so that a target node related to the queried entity can be searched for with high accuracy.

Abstract: A composition for preventing or treating synucleinopathies, which includes efavirenz or a salt or solvate thereof and a pharmaceutically acceptable carrier, is provided. The composition is useful in preventing or treating synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, because the composition serves to hinder cell-to-cell transmission of alpha-synuclein, prevent intracellular aggregation of ?-synuclein, and inhibit transmission of aggregated ?-synuclein.

Abstract: A composition for preventing or treating synucleinopathies, which includes nevirapine or a salt or solvate thereof and a pharmaceutically acceptable carrier, is provided. The composition is useful in preventing or treating synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, because the composition serves to hinder cell-to-cell transmission of ?-synuclein, prevent intracellular aggregation of ?-synuclein, and inhibit transmission of aggregated ?-synuclein.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating non-alcoholic fatty liver disease, comprising trametinib. The composition of the present invention, which comprises trametinib, reduces steatosis, inflammation, or ballooning in liver tissue where non-alcoholic fatty liver has been induced; reduces the level of fibrosis of inflammation induced by non-alcoholic fatty liver; and reduces the weight of a liver that has increased due to non-alcoholic fatty liver disease. Accordingly, the composition of the present invention can be provided for use in preventing or treating metabolic liver disease, including non-alcoholic fatty liver disease.

Abstract: Provided is a method, whereby data is collected from a plurality of databases to build a graph database, and an artificial neural network is trained based on the data stored in the built graph database so that an entity, for example, a disease, a gene, or a protein related to a queried entity on the artificial neural network for which the training has been completed, may be predicted, and a system built by using the same.

Abstract: A method of predicting therapeutic efficacy of a combined drug is provided. The method of predicting therapeutic efficacy of a combined drug can be useful in efficiently predicting therapeutic efficacy of the combined drug on cells by establishing and learning data through a computer using data on cells, data on individual drugs, and data on reaction between the cells and the individual drugs.

Abstract: Provided is a method of screening a protein capable of binding to a specific compound using gene ontology terms.

Abstract: Provided is a method of generating a toxicity prediction model for a microorganism, a method of predicting the toxicity of a chemical substance to a microorganism using the toxicity prediction model, and a method of assigning priorities to biosynthetic pathways for a target material using the toxicity prediction method.

Abstract: Disclosed is a web-based platform for analyzing large-scale TOF-SIMS data and a method thereof. The web-based platform for analyzing large-scale TOF-SIMS data according to the present invention comprises: a communication unit for providing a connected user terminal with a web page and receiving a file for analyzing the TOF-SIMS data from the user terminal via the provided web page; a processing unit for analyzing the TOF-SIMS data using the received file and providing the user terminal with information created based on a result of the analysis via the communication unit; and a storage unit for storing the information created based on the result of the analysis. Through the platform, the present invention may provide a web-based tool that can be used in an automated analysis method.