Patents by Inventor Sojin Shikano

Sojin Shikano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to assay test substances
    Patent number: 7883893
    Abstract: Membrane proteins represent ˜30% of the proteome of both prokaryotes and eukaryotes. Unique to cell surface receptors is their biogenesis pathway, which involves vesicular trafficking from the endoplasmic reticulum through the Golgi apparatus and to the cell surface. Increasing evidence suggests specific regulation of biogenesis for different membrane receptors, hence affecting their surface expression. A pulse-chase assay can be used to monitor function recovery after chemobleaching (FRAC) to probe the transit time of the cell surface receptors to reach the cell surface. This method distinguishes molecular density from functional density. The ability of the reported method to access the biogenesis pathways in a high-throughput manner facilitates the identification and evaluation of molecules affecting receptor trafficking.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: February 8, 2011
    Assignee: The Johns Hopkins University
    Inventors: Min Li, Haiyan Sun, Sojin Shikano
  • Biomolecule partition motifs and uses thereof
    Patent number: 7732165
    Abstract: The invention provides amino acid sequence motifs (e.g., biomolecule partition motifs) that can direct targeting of intracellular polypeptides to and through membranes, including cell surface membranes.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: June 8, 2010
    Assignee: The Johns Hopkins University
    Inventors: Min Li, Sojin Shikano
  • Method to assay test substances
    Publication number: 20070111262
    Abstract: Membrane proteins represent ˜30% of the proteome of both prokaryotes and eukaryotes. Unique to cell surface receptors is their biogenesis pathway, which involves vesicular trafficking from the endoplasmic reticulum through the Golgi apparatus and to the cell surface. Increasing evidence suggests specific regulation of biogenesis for different membrane receptors, hence affecting their surface expression. A pulse-chase assay can be used to monitor function recovery after chemobleaching (FRAC) to probe the transit time of the cell surface receptors to reach the cell surface. This method distinguishes molecular density from functional density. The ability of the reported method to access the biogenesis pathways in a high-throughput manner facilitates the identification and evaluation of molecules affecting receptor trafficking.
    Type: Application
    Filed: November 14, 2005
    Publication date: May 17, 2007
    Applicant: Johns Hopkins University
    Inventors: Min Li, Haiyan Sun, Sojin Shikano
  • Biomolecule partition motifs and uses thereof
    Publication number: 20070031924
    Abstract: The invention provides amino acid sequence motifs (e.g., biomolecule partition motifs) that can direct targeting of intracellular polypeptides to and through membranes, including cell surface membranes.
    Type: Application
    Filed: May 15, 2006
    Publication date: February 8, 2007
    Applicant: The Johns Hopkins University
    Inventors: Min Li, Sojin Shikano