Abstract: A solid-state circuit breaker includes an airgap operating mechanism including components and electronics including semiconductors and software algorithms that control the power and can interrupt extreme currents. The SSCB further includes a housing that houses the components of the airgap operating mechanism and the electronics. The housing of the solid-state circuit breaker includes a heat sink that is part of an outer molded case such that a plastic part of the heat sink is over-molded onto a heat conducting piece that is directly connected to the semiconductors of the solid-state circuit breaker. The plastic part and the heat conducting piece are to be separated into two or more parts if the semiconductors are located at different locations on a printed circuit board such that a thermal bridge to conduct heat between the two or more parts and eventually to a plurality of fins external to the solid-state circuit breaker.

Abstract: Described herein are compounds and methods for the modulation of AKT1 proteins, such as AKT1 E17K. In some aspects, the present disclosure provides an AKT1 protein, wherein a compound is bound to a lysine residue of the AKT1 protein. In another aspect, the present disclosure provides compounds of Formula (I) and (II), useful for the modulation of AKT1 proteins. In another aspect, the instant disclosure provides a method of attenuating AKT1 activity using the compounds described herein.

Abstract: A sports paddle for playing paddle type games is provided. The sports paddle is crafted from sustainable wood materials and is formed in a plurality of layered substrate components comprising a first substrate layer and second substrate layer defining the exterior playing surfaces of the sports paddle, as well as a lightweight core structure that enhances playability and reduces strain during use. The core features hollow, recessed, or solid layers optimizing weight distribution and rigidity of the paddle, while optimizing and improving responsiveness, control, and energy return compared to traditional solid wooden paddles. The sports paddle is further structured with dual exterior playing surfaces and customizable handle configurations, ensuring compliance respective sport regulations while catering to both recreational and competitive players.

Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products for presenting display content on a display of a computing system. A method includes selecting, from a collection of luminance profiles that are each configured to reduce brightness of the display content in different manners, a first luminance profile based on the current display brightness setting, the first luminance profile specifying a first amount of brightness reduction to a peripheral portion of the display content and a first gradient of brightness reduction for a portion of the display content between the peripheral portion of the display content and a center portion of the display content; applying the first luminance profile to the display content to modify the display content by reducing a brightness of the display content according to the first luminance profile; and presenting the display content on the display.

Abstract: A method and system of predicting drug-drug interactions (DDIs) may include receiving: (a) a DDI data structure, representing known DDIs between baseline drugs, (b) a plurality of baseline drug data elements, comprising line-notation descriptions of chemical structure of corresponding baseline drugs, and (c) a substance data element, comprising a line-notation description of a chemical structure of a substance of interest. Embodiments may calculate one or more similarity metric values, representing structural similarity between the substance of interest and specific baseline drugs, and select a subset of the baseline drugs based on the one or more similarity metric values. Embodiments may subsequently predict DDI between the substance of interest and a target baseline drug, based on (i) the selected subset of baseline drugs and (ii) the DDI data structure.

Abstract: Disclosed herein are methods for forming opening ends within semiconductor structures. In some embodiments, a method may include providing an opening formed in a layer of a semiconductor device, wherein the opening comprises a set of sidewalls opposite one another, and first and second end walls connected to the sidewalls, wherein each of the first and second end walls defines a tip end and a set of curved sections extending between the tip end and the set of sidewall. The method may further include performing an ion etch to the opening by delivering an ion beam at a non-zero angle relative to a plane defined by the layer of the semiconductor device, wherein the ion etch comprises a lean-gas chemistry, and wherein the ion etch causes the layer of the semiconductor device to be removed faster along the set of curved sections than along the set of sidewalls.

Abstract: Materials and methods useful in forming nano-scale features on substrates, and articles such as optical films incorporating such nano-scale patterned substrates.

Abstract: A controller is provided that includes a serial data (SDA) line interface to connect the controller to an SDA line of a two-wire, shared, serial data bus. The controller includes processing circuitry to transfer output data on the SDA line, and monitor the SDA line of the data bus while the output data is transferred on the SDA line of the two-wire, shared, serial data bus. The controller detects a stop condition asserted by a target on the data bus while the output data is transferred on the SDA line of the two-wire, shared, serial data bus. The controller then ends transfer of the output data on the SDA line, in response to the detected stop condition.

Abstract: Examples are disclosed that relate to passing complex data objects as context variables between iterative prompts to AI models. One example provides a method, comprising receiving an input, constructing a prompt based upon the input, and inputting the prompt into an orchestrator. The method further comprises, based on the prompt, forming a context variable to reference complex data. The method further comprises providing modified input to a first AI plugin at a first orchestration stage, receiving the complex data from the first AI plugin, and storing the complex data as the context variable. The method further comprises modifying the prompt to include a reference to the context variable without modifying the prompt to include the complex data, thereby forming a modified prompt. The method further comprises providing the modified prompt to a generative model, receiving generated text from the generative model, and outputting the generated text with the complex data.

Abstract: A method of detecting a small area wildfire is described. The method includes: (i) receiving, at a processor, an electronic map of an area of interest; (ii) receiving, at the processor from a satellite, location information for a high-altitude balloon disposed above the area of interest; (iii) determining, using the processor and based one or more different types of sensor data that is received from one or more different types of sensors on the high-altitude balloon and the high-altitude balloon location, one or more wildfire locations; (iv) embedding each of the wildfire locations on the electronic map to produce a fire activity map; and (v) causing to display or displaying the fire activity map including the wildfire locations within the area of interest.

Abstract: Compounds of Formulae (I), (II) and (III), including pharmaceutically acceptable salts are described herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions a disease or disorder that can be treated with a KOR agonist and/or MOR agonist. Compounds described herein, along with pharmaceutically acceptable salts and compositions thereof, can be used to alleviate at least one symptom of the disease or disorder described herein.

Abstract: A controller is provided that includes a serial data (SDA) line interface to connect the controller to an SDA line of a two-wire, shared, serial data bus. The controller includes a circuitry to provide output data for transfer on to the SDA line via the output SDA pad buffer. The controller includes a logic circuit that is external to the circuitry, and that monitors data on the SDA line while the output data is transferred on to the SDA line. The logic circuit compares the monitored data on the SDA line and the output data to detect an error condition when the monitored data and the output data differ. The logic circuit disables an output SDA pad buffer of the SDA line interface for a current byte of the output data provided by the circuitry, and then causes a stop condition on the data bus.

Abstract: Computing devices, touchpads, and related methods for adjusting a force threshold for touch input on a touchpad are disclosed. In one example, a computing device comprises a force sensing touchpad, a processor, and a memory storing instructions executable by the processor to receive a first contact on the touchpad. An area of touch of the first contact is determined, and an adjusted force threshold for touch input is determined based at least on the area of the touch. A second contact is received on the touchpad, and a touch force of the second contact is determined. Based at least on determining that the touch force exceeds the adjusted force threshold, a touch input on the touchpad is registered.

Abstract: Devices and methods for administering a medication in fluid form, the systems and methods including a basal flow path and a bolus flow path in parallel to the basal flow path. The bolus flow path includes a combined piston pump and rotatable valve. The piston pump is configured to prevent partial dosing of a bolus dose.

Abstract: An impeller includes a cylindrical portion defining a fluid inlet, the cylindrical portion coaxial with a rotational axis of the impeller, a hub, a shroud extending downward and radially away from the cylindrical portion and covering the hub, a plurality of vanes extending between the shroud and the hub, a fluid outlet downstream of the plurality of vanes, a plurality of doors disposed circumferentially about the cylindrical portion proximate the inlet, and a spring element attached to and disposed between each of the plurality of doors and the cylindrical portion. Each of the plurality of doors is actuatable, via the spring element, between a first state and a second state.

Abstract: In one embodiment, a device receives, via a user interface, definition of a first sequence of transactional milestones performed by users of an online application and identified using a first type of identifier. The device also receives, via the user interface, definition of a second sequence of transactional milestones performed by users of the online application and identified using a second type of identifier. The device further receives, via the user interface, definition of a key transition associated with at least one transactional milestone in the first sequence of transactional milestones or second sequence of transactional milestones that links the first type of identifier with the second type of identifier. The device represents, using the key transition, performance of the first sequence of transactional milestones and the second sequence of transactional milestones by a particular user of the online application as a unified sequence.

Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Abstract: The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the complement component C3 gene (C3). The invention also relates to methods of using such RNAi agents to inhibit expression of a C3 gene and to methods of preventing and treating a C3-associated disorder, e.g., cold agglutinin disease (CAD), warm autoimmune hemolytic anemia, and paroxysmal nocturnal hemoglobinuria (PNH), lupis nephritis (LN), bullous pemphigoid, pemphigus, e.g., pemphigus vulgaris (PV) and pemphigus foliaceus (PF), and C3 glomerulopathy.

Abstract: A hydrogel particle, comprising a matrix comprising a polymerized monomer, said matrix comprising a plurality of micropores and a plurality of macropores, and one or more immunostimulatory biomolecules selected from the group consisting of an anti-CD3 antibody or antigen-binding fragment thereof, an anti-CD28 antibody or antigen-binding fragment thereof, and combinations thereof.