Patents by Inventor Solomon Garner
Solomon Garner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230330030Abstract: Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.Type: ApplicationFiled: June 19, 2023Publication date: October 19, 2023Inventors: Kinam Park, Yeonhee Yun, Sarah Michelle Skidmore, Byung Kook Lee, John Solomon Garner
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Patent number: 11723876Abstract: Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.Type: GrantFiled: February 8, 2021Date of Patent: August 15, 2023Assignee: SK JOINT VENTURES II, LLCInventors: Kinam Park, Yeonhee Yun, Sarah Michelle Skidmore, Byung Kook Lee, John Solomon Garner
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Publication number: 20220040381Abstract: The invention provides methods and polymer-containing formulations for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups. Formulations are provided containing a nucleo-functional polymer, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier, for use in the therapeutic methods.Type: ApplicationFiled: March 30, 2021Publication date: February 10, 2022Applicant: Pykus Therapeutics, Inc.Inventors: Laurence A. ROTH, James Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI, John Solomon GARNER
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Publication number: 20210403639Abstract: A solid crosslinked polyester composition is disclosed wherein the crosslinked polyester is environmentally degradable in less than about 180 days. The crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds. Alternately, the crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester.Type: ApplicationFiled: June 22, 2021Publication date: December 30, 2021Applicant: Akina, IncInventors: John Solomon Garner, Kinam Park
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Publication number: 20210161826Abstract: Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.Type: ApplicationFiled: February 8, 2021Publication date: June 3, 2021Inventors: Kinam Park, Yeonhee Yun, Sarah Michelle Skidmore, Byung Kook Lee, John Solomon Garner
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Patent number: 10925837Abstract: Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.Type: GrantFiled: August 23, 2017Date of Patent: February 23, 2021Assignee: AKINA, INC.Inventors: Kinam Park, Yeonhee Yun, Sarah Michelle Skidmore, Byung Kook Lee, John Solomon Garner
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Publication number: 20200338233Abstract: Provided are methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions or polymer-containing formulations that can form a hydrogel in the eye of a subject. In certain embodiments, the hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.Type: ApplicationFiled: January 11, 2019Publication date: October 29, 2020Applicant: Pykus Therapeutics, Inc.Inventors: Laurence A. ROTH, James Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI, John Solomon GARNER
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Publication number: 20190216982Abstract: The invention provides methods and polymer-containing formulations for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups. Formulations are provided containing a nucleo-functional polymer, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier, for use in the therapeutic methods.Type: ApplicationFiled: January 11, 2019Publication date: July 18, 2019Inventors: Laurence A. ROTH, James Anthony STEFATER, III, Tomasz Pawel STRYJEWSKI, John Solomon GARNER
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Patent number: 10011689Abstract: The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.Type: GrantFiled: April 13, 2015Date of Patent: July 3, 2018Assignees: Akina, Inc., THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Kinam Park, Clark Tobias Barco, Haesun Park, Yourong Fu, John Solomon Garner
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Publication number: 20180055779Abstract: Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.Type: ApplicationFiled: August 23, 2017Publication date: March 1, 2018Inventors: Kinam Park, Yeonhee Yun, Sarah Michelle Skidmore, Byung Kook Lee, John Solomon Garner
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Publication number: 20170362566Abstract: The present invention provides the use of selected thermogelling polymers for the purpose of growing tumor spheroids. The invention provides a thermogelling platform comprising a synthetic polymer which, when seeded with cancer cells, induces the cells to grow into a natural spheroidal pattern forming a tumor spheroid. After accomplishing this in about 3-10 days, the gel washes away, leaving behind the spheroids.Type: ApplicationFiled: December 7, 2015Publication date: December 21, 2017Inventors: JOHN SOLOMON GARNER, SARAH MICHELLE SKIDMORE, JUSTIN CHARLES HADAR, Burnsoo HAN, KINAM PARK
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Publication number: 20170037196Abstract: The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.Type: ApplicationFiled: April 13, 2015Publication date: February 9, 2017Applicants: Akina, Inc. (an Indiana corporation), The United States Government as Represented by the Department of Veterans AffairsInventors: Kinam Park, Clark Tobias Barco, Haesun Park, Yourong Fu, John Solomon Garner
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Publication number: 20080020997Abstract: Mutual prodrugs of glucosamine, and derivatives and analogs of glucosamine and an anti-inflammatory agent, compositions thereof, and methods for, e.g., treating disorders and conditions by administration of the compositions are provided. Topical compositions of glucosamine, and derivatives and analogs of glucosamine are also provided.Type: ApplicationFiled: April 7, 2005Publication date: January 24, 2008Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Anthony Capomacchia, Solomon Garner, J. Warren Beach