Patents by Inventor Solomon S. Klioze

Solomon S. Klioze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods related to the A-C repeat Z-sequence upstream from the aldose reductase gene
    Publication number: 20030114357
    Abstract: This invention relates to methods of characterizing subjects and methods of treatment or prevention of diseases and pathological conditions relating to the polymorphic A-C repeat sequence located approximately 2.1 kb upstream from the aldose reductase gene.
    Type: Application
    Filed: September 27, 2002
    Publication date: June 19, 2003
    Inventors: David A. Fryburg, Solomon S. Klioze, Patrice M. Milos, Peter J. Oates
  • cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and intermediates thereof
    Patent number: 4585779
    Abstract: cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and methods of preparing same are described. On the nitrogen atom there may be a substituent including loweralkyl, loweralkenyl, phenylloweralkyl, hydrogen cyanoloweralkyl, phenylcarbonylloweralkyl, phenoxyloweralkyl and cycloalkylloweralkyl. The 4a-aryl group may be a phenyl, mono-halogen substituted phenyl, tolyl, methoxyphenyl, hydroxyphenyl, or furyl. These compounds are useful as analgesic and anticonvulsant agents.3-o-Fluorophenyl-1-methyl-4-aryl-4-piperidinols which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: April 29, 1986
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Solomon S. Klioze
  • Cis-4a-aryl, 1, 2, 3, 4, 4A, 9B-hexahydro-benzofuro-[3,2-C]- pyridines useful as analgesics
    Patent number: 4544745
    Abstract: Cis-4a-aryl, 1, 2, 3, 4, 4A, 9B-hexahydro-benzofuro-[3,2-C]- pyridines, useful as analgesic and anticonvulsant agents are described.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: October 1, 1985
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Solomon S. Klioze
  • cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and their anti-convulsant and analgesic activity
    Patent number: 4507306
    Abstract: cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and methods of preparing same are described. On the nitrogen atom there may be a substituent including loweralkyl, loweralkenyl, phenylloweralkyl, hydrogen, cyanoloweralkyl, phenylcarbonylloweralkyl, phenoxyloweralkyl and cycloalkylloweralkyl. The 4a-aryl group may be a phenyl, mono-halogen substituted phenyl, tolyl, methoxyphenyl, hydroxyphenyl, or furyl. These compounds are useful as analgesic and anticonvulsant agents.3-o-Fluorophenyl-1-methyl-4-aryl-4-piperidinols which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.
    Type: Grant
    Filed: July 22, 1982
    Date of Patent: March 26, 1985
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Solomon S. Klioze
  • 1-(Substituted) piperazine-4-benzenesulfinamides, compositions and method of use
    Patent number: 4425342
    Abstract: Benzenesulfinamides of the formula ##STR1## wherein R is pyridyl, phenyl or phenyl substituted by halogen, loweralkyl, loweralkoxy or trifluoromethyl and the pharmaceutically acceptable acid addition salts thereof are useful blood pressure reducing agents.
    Type: Grant
    Filed: March 29, 1979
    Date of Patent: January 10, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals
    Inventors: Richard C. Allen, Solomon S. Klioze
  • Process for preparing 4-aryloxy-3-phenylpiperidines
    Patent number: 4424357
    Abstract: Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.
    Type: Grant
    Filed: December 28, 1979
    Date of Patent: January 3, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Solomon S. Klioze, Frederick J. Ehrgott
  • Cis- and trans-4-(4-bromophenoxy)-1-[6-fluoro-1,2-benzisoxazole-3-yl)propyl]-3-ph enylpiperidines
    Patent number: 4382141
    Abstract: Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.
    Type: Grant
    Filed: October 2, 1981
    Date of Patent: May 3, 1983
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Solomon S. Klioze, Frederick J. Ehrgott
  • Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
    Patent number: 4312876
    Abstract: Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: January 26, 1982
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Solomon S. Klioze, Frederick J. Ehrgott
  • Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
    Patent number: 4302590
    Abstract: Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.
    Type: Grant
    Filed: December 28, 1979
    Date of Patent: November 24, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Solomon S. Klioze, Frederick J. Ehrgott
  • Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
    Patent number: 4216218
    Abstract: Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: August 5, 1980
    Assignee: American Hoechst Corporation
    Inventors: Solomon S. Klioze, Frederick J. Ehrgott
  • Phenylsulfenylpiperazines
    Patent number: 4015004
    Abstract: Novel phenylsulfenylpiperazines and a method of preparing the same are disclosed. These compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: August 26, 1975
    Date of Patent: March 29, 1977
    Assignee: American Hoechst Corporation
    Inventors: Solomon S. Klioze, Richard C. Allen
  • 1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s
    Patent number: 3996354
    Abstract: Novel 1,3-dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro[isobenzofuran]s and methods of preparing the same are described. These compounds are useful as antidepressants.
    Type: Grant
    Filed: January 26, 1976
    Date of Patent: December 7, 1976
    Assignee: American Hoechst Corporation
    Inventor: Solomon S. Klioze
  • 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives
    Patent number: 3980787
    Abstract: Novel 3-phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives and a method of preparing the same are described. These compounds are useful as diuretic and antihypertensive agents.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: September 14, 1976
    Assignee: American Hoechst Corporation
    Inventors: Solomon S. Klioze, William J. Novick, Jr.