Patents by Inventor Solomon Snyder
Solomon Snyder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060246076Abstract: Cyclooxygenase (COX2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to COX2 and S-nitrosylates it, enhancing COX2 catalytic activity. Selectively disrupting iNOS—COX2 binding prevents NO-mediated activation of COX2. The synergistic molecular interaction between two inflammatory systems permits assays for developing anti-inflammatory drugs.Type: ApplicationFiled: April 28, 2006Publication date: November 2, 2006Applicant: The Johns Hopkins UniversityInventors: Solomon Snyder, Sangwon Kim
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Publication number: 20050026227Abstract: Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain nitrosothiols involves several steps. Nitrosylated cysteines are converted to tagged cysteines. Tagged proteins can then be detected, for example, by immunoblotting and/or can be purified by affinity chromatography. The method is applicable to the detection of S-nitrosylated proteins in cell lysates following in vitro S-nitrosylation, as well as to the detection of endogenous S-nitrosothiols in selected protein substrates.Type: ApplicationFiled: August 27, 2004Publication date: February 3, 2005Applicants: The Johns Hopkins University, Memorial Sloan-Kettering Cancer CenterInventors: Solomon Snyder, Samie Jaffrey, Christopher Ferris, Hediye Erdjument-Bromage, Paul Tempst
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Publication number: 20050004222Abstract: Disclosed are methods for preventing or treating a gastrointestinal (GI) disorder in a mammal such as a human patient. In one embodiment, the methods include administering to the mammal a therapeutically effective amount of a compound that modulates a nitric oxide (NO) signaling pathway, particularly in GI neurons. Methods of the invention are particularly useful for the treatment (including prophylactic treatment) of diabetic gastropathies and other GI disorders.Type: ApplicationFiled: May 28, 2004Publication date: January 6, 2005Inventors: Crystal Watkins, Solomon Snyder, Christopher Ferris
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Publication number: 20030203890Abstract: The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.Type: ApplicationFiled: May 29, 2002Publication date: October 30, 2003Inventors: Joseph P. Steiner, Solomon Snyder, Arthur L. Burnett
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Publication number: 20030114365Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: ApplicationFiled: August 27, 2002Publication date: June 19, 2003Applicant: GPI NIL Holding, Inc.Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Patent number: 6500843Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: GrantFiled: November 5, 1999Date of Patent: December 31, 2002Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of MedicineInventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Publication number: 20020052372Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: ApplicationFiled: November 5, 1999Publication date: May 2, 2002Inventors: JOSEPH P. STEINER, SOLOMON SNYDER, GREGORY S. HAMILTON, TED DAWSON
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Patent number: 6358975Abstract: Neutral tissue damage resulting for ischemia and reperfusion injury or neurodegenerative diseases can be prevented by administering therapeutically effective amounts of certain selective inhibitors of poly(ADP-ribose)polymerase. The inhibitors can be administered intravenously, intraperitoneally, intramuscularly, intraventricularly, or orally. They can be administered as a capsule or tablet containing single or divided dose. Alternatively, the inhibitors can be administered as a sterile solution, suspension or emulsion.Type: GrantFiled: February 11, 2000Date of Patent: March 19, 2002Assignee: Johns Hopkins UniversityInventors: Mikael J. Eliasson, Kenji Sampei, Allen S. Mandir, Patricia D. Hurn, Richard J. Traystman, Jun Bao, Andrew Pieper, Ted M. Dawson, Solomon Snyder, Valina L. Dawson
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Patent number: 6022878Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: GrantFiled: July 10, 1998Date of Patent: February 8, 2000Assignees: GPI NIL Holdings, Inc., John Hopkins University School of MedicineInventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Patent number: 5846981Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: GrantFiled: January 23, 1997Date of Patent: December 8, 1998Assignees: GPI NIL Holdings Inc., Johns Hopkins University School of MedicineInventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Patent number: 5843960Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: GrantFiled: January 23, 1997Date of Patent: December 1, 1998Assignees: GPI Nil Holdings, Inc., Johns Hopkins University School of MedicineInventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Patent number: 5798355Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: GrantFiled: June 7, 1995Date of Patent: August 25, 1998Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of MedicineInventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Patent number: 5696135Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.Type: GrantFiled: May 28, 1996Date of Patent: December 9, 1997Assignees: GPI NIL Holdings, Inc., Johns Hopkins Univ. School of MedicinesInventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton
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Patent number: 5318907Abstract: Primary cultures of purified olfactory neurons can be stimulated with physiological levels of odorants. The neurons of the cultures express markers characteristic of mature olfactory neurons in vivo, such as vimentin, olfactory marker protein and neuron-specific enolase. The cultures are useful for screening for odorants and antagonists, as well as for biochemical and physiological studies of olfactory transduction.Type: GrantFiled: October 6, 1992Date of Patent: June 7, 1994Assignee: The Johns Hopkins UniversityInventors: Gabriele Ronnett, Lynda Hester, Solomon Snyder