Abstract: A gas turbine engine is provided, comprising: a turbomachine having a compressor section, a combustion section, and a turbine section in serial flow order; and a fan section having a fan drivingly coupled to the turbomachine and an airflow surface rotatable with the fan and exposed to a fan airflow provided to and through the fan during operation of the gas turbine engine, the airflow surface defining a plurality of boundary layer openings configured to ingest a boundary layer of the fan airflow over the airflow surface during operation of the gas turbine engine.

Abstract: A vehicle having a tail lift is disclosed. The tail lift may be configured to move between a retracted position and an extended position. The tail lift may be disposed perpendicular to a vehicle cargo bed in the retracted position, and parallel to the vehicle cargo bed in the extended position. The vehicle may further include a detection unit configured to detect a placement location of a cargo on the tail lift and presence of an obstruction in proximity to the tail lift. The vehicle may additionally include a processor that may obtain inputs from the detection unit when the tail lift may be in the extended position. The processor may determine that a predefined condition may be met based on the obtained inputs. The processor may further output a notification responsive to a determination that the predefined condition may be met.

Abstract: A refrigerated delivery vehicle is disclosed. The vehicle may include a refrigerated cargo zone configured to store a plurality of delivery packages. The refrigerated cargo zone may include an access door. The vehicle may further include a detection unit configured to detect a user movement in the refrigerated cargo zone and an access door movement when the vehicle may be traversing a delivery route or parked. The vehicle may further include a processor configured to obtain inputs from the detection unit, and determine a user inefficiency parameter based on the inputs. The processor may be further configured to compare the user inefficiency parameter with a threshold inefficiency parameter. The processor may output a notification instructing the user to reduce the user movement or the access door movement when the user inefficiency parameter may be greater than the threshold inefficiency parameter.

Abstract: Provided herein are compositions that immunospecifically bind to Siglec-15, small molecules, peptides, or other entities that may bind Siglec-15 in a similar fashion. Methods of use are provided for Siglec-15 targeting therapeutics to restore bone homeostasis by inhibiting bone resorption and increase bone formation, specifically in non-ambulatory people or in people with disuse osteoporosis. The therapeutics referenced here may be used to overcome the need for mechanical loading on the bone to maintain high quality skeleton.

Abstract: Embodiments disclosed herein may provide digital medicine support for predicting and mitigating side effects of bispecific antibody treatment (e.g., Pfizer's Elranatamab) for myeloma patients. The side effects may include cytokine release syndrome (CRS), infection (e.g., sepsis), neurotoxicity (e.g., peripheral neuropathy), cytopenia (e.g., neutropenia), etc. These side effects may be predicted based on passive collection of data from patient wearables, patient entered data on healthcare application, and other data such as bloodwork data. Trained machine learning models may be used for predicting the side effects. As the side effects may be predicted before their onsets, a proactive intervention may be feasible to improve the healthcare outcomes for myeloma patients.

Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: A network communication system which provides cost effective support for two or more WAN transports from a single SD-WAN site. The network communication system, may at times by default, monitor a higher-cost WAN for only basic connectivity to reduce monitoring costs of the transport. Where an application is properly configured, the system may override the default to monitor a higher-cost WAN for acceptable performance (i.e., monitored for connectivity, packet loss, latency, jitter & capacity) even when that WAN is not selected as active transport.

Abstract: The present disclosure provides an article including a layer having a nanostructured first surface including nanofeatures and an opposing second surface, and an organic layer including a major surface attached to a portion of the nanofeatures. The nanostructured first surface includes protruding features that are formed of a single composition and/or recessed features. The nanofeatures and the major surface of the second layer together define at least one void. The present disclosure also provides a method of making the article including contacting nanofeatures of a layer having a nanostructured surface with a major surface of an organic layer and reacting at least one material to secure the two layers together. In addition, the present disclosure provides an optical information display and an OLED device including the article. The nanostructured surface of the article is protected from damage and contamination by the organic layer.

Abstract: A coating on a surface of a metallic substrate which includes one or more layers of DLC (Diamond-Like Carbon) containing silicon and oxygen. The coatings optionally have an intermediate layer, such as a nitrocarburized layer. A method of producing a non-stick coating on a surface of a metallic material. The method includes producing one of nitriding layer, nitrocarburization layer, and carburization layer on the surface of a metallic material by one of ion plasma nitriding, gas nitriding, and salt bath nitriding; and producing one or more layers of DLC, each layer containing silicon and oxygen on top of and in contact with the nitrocarburized layer by a plasma enhanced chemical vapor deposition (PECVD) vacuum process. An article containing on its surface one or more layers of DLC containing silicon and oxygen, and optionally an intermediate layer.

Abstract: The present disclosure provides methods and compositions related to the modification of immune effector cells to increase therapeutic efficacy. In some embodiments, immune effector cells modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance effector functions of the immune cells are provided. In some embodiments, immune effector cells further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating a cell proliferative disorder, such as a cancer, using the modified immune effector cells described herein are also provided.

Abstract: Presented herein are efficient techniques through which it may be identified that a user device has transmitted a threshold number of signaling messages associated with one or more requests in a first time period. The user device may be placed in a suppression state based on the identifying and the user device may be removed from the suppression state when no signaling messages associated with the one or more requests are received during a second time period or when a signaling message associated with a different request is received from the user device.

Abstract: A computer-implemented method, according to one embodiment, includes: intentionally causing faults to be injected in a compute infrastructure, and determining whether the injected faults cause application failures. Weights are also assigned to the injected faults based on severity of the respective application failures. The weighted faults are compared, and changes to the compute infrastructure are recommended based on the comparison. Moreover, the changes that are recommended are configured to prevent the application failures. Other systems, methods, and computer program products are described in additional embodiments.

Abstract: A system for joining a first part and a second part together with a weld structure. The system includes: a welding element configured to form the weld structure between the first part and the second part; and a control module configured to operate the welding element to form the weld structure. The weld structure includes: a first curved end; a second curved end; a connecting portion connecting the first curved end and the second curved end; a first curved crown spaced apart from the first curved end and concentric with the first curved end; and a second curved crown spaced apart from the second curved end and concentric with the second curved end. The first curved end, the second curved end, and the connecting portion are between the first curved crown and the second curved crown.

Abstract: An order fulfillment system is disclosed including a multi-level tote storage structure, one or more autonomous mobile robots configured to pick, transport and place one or more tote; one or more workstations configured to accommodate a picker that transports one or more eaches from a tote on one of the autonomous mobile robots to a “put” location, wherein the autonomous mobile robots are configured to move from level to level in the order fulfillment apparatus.

Abstract: Methods and systems are provided for managing vehicle manifest data at a vehicle. Vehicle manifest data is received from a plant operation system at a vehicle manifest data management system of the vehicle. The vehicle manifest data includes a plurality of component identifiers. Each of the component identifiers corresponds to a vehicle component for installation in the vehicle during a vehicle assembly process. The vehicle manifest data includes installation data associated with the installation of each of the vehicle components. A first component identifier associated with a first vehicle component and a first assembly station identifier associated with a first assembly station equipped to install the first vehicle component are received at the vehicle manifest data management system from the plant operation system. The installation data associated with the first vehicle component is transmitted from the vehicle manifest data management system to a station controller of the first assembly station.

Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Abstract: A device for detecting optical chirality includes a metasurface composed of a biperiodic array of nanodisks in the form of a checkerboard array [300], where the nanodisks have diameters d±?/2 such that adjacent nanodisks [302, 304] have diameters that differ by an offset ?. The nanodisks are composed of a dielectric material that is transparent and has a refractive index greater than 2 at a predetermined operational ultraviolet wavelength. The nanodisks have a width-to-height aspect ratio d/h tuned to produce spectral overlap of electric dipole and magnetic dipole modes of incident circularly polarized ultraviolet light.

Abstract: An apparatus is for forming a balloon layer, such as on an expanded base balloon. The apparatus includes a mandrel supporting the expanded base balloon. At least one gripper is provided for gripping the balloon layer, and an actuator is for stretching the balloon layer over the expanded base balloon, such as by moving the at least one gripper. Related methods for forming a balloon layer are also disclosed.

Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.