Patents by Inventor Somarajan Janardanan Nair

Somarajan Janardanan Nair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF
    Publication number: 20070191410
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Application
    Filed: April 18, 2007
    Publication date: August 16, 2007
    Inventors: Julian ADAMS, Alfredo CASTRO, Michael FOLEY, Somarajan JANARDANAN NAIR, Marta NEVALAINEN, James PORTER, Martin TREMBLAY
  • Cyclopamine analogues and methods of use thereof
    Publication number: 20060074030
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Application
    Filed: August 26, 2005
    Publication date: April 6, 2006
    Inventors: Julian Adams, Alfredo Castro, Michael Foley, Somarajan Janardanan Nair, Marta Nevalainen, James Porter, Martin Tremblay