Patents by Inventor Somasekar Seshagiri

Somasekar Seshagiri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EGFR MUTATIONS
    Publication number: 20130071382
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Application
    Filed: June 29, 2012
    Publication date: March 21, 2013
    Inventor: Somasekar Seshagiri
  • EGFR mutations
    Patent number: 8232053
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: July 31, 2012
    Assignee: Genentech, Inc.
    Inventor: Somasekar Seshagiri
  • EGFR mutations
    Patent number: 8232062
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: July 31, 2012
    Assignee: Genetech, Inc.
    Inventor: Somasekar Seshagiri
  • EGFR MUTATIONS
    Publication number: 20110275072
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Application
    Filed: April 27, 2011
    Publication date: November 10, 2011
    Inventor: Somasekar Seshagiri
  • EGFR MUTATIONS
    Publication number: 20110229890
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Application
    Filed: April 27, 2011
    Publication date: September 22, 2011
    Inventor: Somasekar Seshagiri
  • EGFR mutations
    Patent number: 7960118
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: June 14, 2011
    Assignee: Genentech, Inc.
    Inventor: Somasekar Seshagiri
  • EGFR mutations
    Patent number: 7932026
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: April 26, 2011
    Assignee: Genentech, Inc.
    Inventor: Somasekar Seshagiri
  • EGFR MUTATIONS
    Publication number: 20100297615
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Application
    Filed: November 17, 2008
    Publication date: November 25, 2010
    Inventor: Somasekar Seshagiri
  • PRO34128 nucleic acids
    Publication number: 20100285016
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: November 19, 2009
    Publication date: November 11, 2010
    Inventors: J. Christopher Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William I. Wood, Zemin Zhang
  • GENETIC VARIATIONS ASSOCIATED WITH TUMORS
    Publication number: 20100092965
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Application
    Filed: November 15, 2007
    Publication date: April 15, 2010
    Inventors: Somasekar Seshagiri, Brock Peters, Zhengyan Kan
  • GENETIC VARIATIONS ASSOCIATED WITH TUMORS
    Publication number: 20100055095
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Application
    Filed: October 24, 2007
    Publication date: March 4, 2010
    Inventors: Zhengyan Kan, Denise M. Kenski, Brock Peters, Somasekar Seshagiri
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND ALLEVIATION OF TUMOR
    Publication number: 20100034836
    Abstract: The present invention is directed to methods of determining the presence of certain tumor-associated kinase polypeptides in a biological sample, and to compositions useful for the diagnosis and treatment of tumors in mammals
    Type: Application
    Filed: December 6, 2006
    Publication date: February 11, 2010
    Inventors: Klaus P. Hoeflich, Somasekar Seshagiri
  • GENETIC VARIATIONS ASSOCIATED WITH TUMORS
    Publication number: 20100034821
    Abstract: Tumor-associated variations in protein kinases are provided. Compositions and methods for detecting such variations and for diagnosing and treating tumors are provided.
    Type: Application
    Filed: January 10, 2008
    Publication date: February 11, 2010
    Inventors: Jose F. Bazan, Joshua Kaminker, Brock Peters, Somasekar Seshagiri, Zemin Zhang
  • PRO34128 polypeptides
    Patent number: 7642242
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: January 5, 2010
    Assignee: Genentech, Inc.
    Inventors: J. Christopher Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William I. Wood, Zemin Zhang
  • PRO34128 antibodies
    Patent number: 7576185
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: August 18, 2009
    Assignee: Genentech, Inc.
    Inventors: J. Christopher Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William I. Wood, Zemin Zhang
  • Vectors and Methods Using Same
    Publication number: 20080220471
    Abstract: The present invention is directed to vectors and to methods of using same.
    Type: Application
    Filed: July 27, 2006
    Publication date: September 11, 2008
    Applicant: Genentech, Inc.
    Inventors: David P. Davis, Daniel C. Gray, Klaus P. Hoeflich, Somasekar Seshagiri
  • Novel polypeptides having sequence similarity to GDNFR and nucleic acids encoding the same
    Publication number: 20080108563
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 20, 2007
    Publication date: May 8, 2008
    Inventors: J. Christopher Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William I. Wood, Zemin Zhang
  • PRO34128 nucleic acids
    Patent number: 7247446
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: July 24, 2007
    Assignee: Genentech, Inc.
    Inventors: J. Christopher Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William I. Wood, Zemin Zhang
  • Novel polypeptides having sequence similarity to GDNFR and nucleic acids encoding the same
    Publication number: 20070154475
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 20, 2007
    Publication date: July 5, 2007
    Inventors: J. Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William Wood, Zemin Zhang
  • EGFR mutations
    Publication number: 20050272083
    Abstract: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein in a tumor sample whereby the presence of a mutated EGFR gene or protein indicates the tumor is susceptible to treatment.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 8, 2005
    Inventor: Somasekar Seshagiri