Abstract: A system and method of operation of an imaging system includes: a capture module for receiving an input sequence with an image pair, the image pair having a first image and a second image and for determining a first patch from the first image and a second patch from the second image; an iteration module for generating an iteration map from the first patch of the first image and the second patch of the second image; and a position module for generating a final depth map from the iteration map and for determining a focus position from the final depth map.

Abstract: Systems, methods, and apparatuses are provided for determining a sequence of a heteropolymer molecule. For example, all or part of a chromosome or a protein can be determined using sequence data from a plurality of heteropolymer fragments corresponding to the heteropolymer molecule. As one example, a position in the sequence read of a DNA fragment can be identified where a single base call is not clear. A multiplet base call can then be used, where the multiplet base call includes two or more bases at the position, along with a score for each base. The scores can be carried through mapping and assembly procedures, where the scores can be used to determine a final base call for the position in a chromosome of a genome of an organism. Other examples can be used for other monomer units besides bases.

Abstract: A system and method of operation of an imaging system includes: a capture module for receiving an input sequence with an image pair, the image pair having a first image and a second image and for determining a first patch from the first image and a second patch from the second image; an iteration module for generating an iteration map from the first patch of the first image and the second patch of the second image; and a position module for generating a final depth map from the iteration map and for determining a focus position from the final depth map.