Patents by Inventor Somshuvra Mukhopadhyay

Somshuvra Mukhopadhyay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD TO TREAT MANGANESE TOXICITY AND MANGANESE-INDUCED PARKINSONISM IN HUMANS
    Publication number: 20230101768
    Abstract: Disclosed is a method for treating manganese (manganese) toxicity in a subject. The method includes administering to the subject an effective amount of a hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: August 13, 2022
    Publication date: March 30, 2023
    Inventors: Somshuvra Mukhopadhyay, Chunyi Liu, Donald Smith
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF SHIGA TOXICOSIS
    Publication number: 20220202747
    Abstract: Methods for treating Shiga toxicosis, caused by infection with Shiga toxin bacteria, are provided. The methods include administering to a subject in need thereof an effective amount of one or more active agents selected from tamoxifen, 4-hydroxytamoxifen, endoxifen, toremifene, raloxifene, bazedoxifene, and pharmaceutically acceptable salts thereof. In some embodiments, the methods further include the administration of an antibiotic or a manganese compound to the subject. Pharmaceutical compositions for the treatment of Shiga toxicosis are also described.
    Type: Application
    Filed: March 18, 2022
    Publication date: June 30, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Somshuvra Mukhopadhyay, Andrey S. Selyunin, Stanton F. McHardy
  • Methods and compositions for the treatment of Shiga Toxicosis
    Patent number: 11304916
    Abstract: Methods for treating Shiga toxicosis, caused by infection with Shiga toxin bacteria, are provided. The methods include administering to a subject in need thereof an effective amount of one or more active agents selected from tamoxifen, 4-hydroxytamoxifen, endoxifen, toremifene, raloxifene, bazedoxifene, and pharmaceutically acceptable salts thereof. In some embodiments, the methods further include the administration of an antibiotic or a manganese compound to the subject. Pharmaceutical compositions for the treatment of Shiga toxicosis are also described.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: April 19, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Somshuvra Mukhopadhyay, Andrey S. Selyunin, Stanton F. McHardy
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF SHIGA TOXICOSIS
    Publication number: 20200375923
    Abstract: Methods for treating Shiga toxicosis, caused by infection with Shiga toxin bacteria, are provided. The methods include administering to a subject in need thereof an effective amount of one or more active agents selected from tamoxifen, 4-hydroxytamoxifen, endoxifen, toremifene, raloxifene, bazedoxifene, and pharmaceutically acceptable salts thereof. In some embodiments, the methods further include the administration of an antibiotic or a manganese compound to the subject. Pharmaceutical compositions for the treatment of Shiga toxicosis are also described.
    Type: Application
    Filed: June 2, 2020
    Publication date: December 3, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Somshuvra Mukhopadhyay, Andrey S. Selyunin, Stanton F. McHardy
  • Methods and compositions for reducing Shiga toxin induced toxicity in mammals
    Patent number: 9439438
    Abstract: Manganese compositions effective in reducing Shiga toxin-induced toxicity in mammals infected with Shiga toxin-producing bacteria such as E. coli O157:H7 are described. Manganese compositions described herein can be combined with antibiotic therapy as manganese can block the toxic effects of Shiga toxin released from dying bacteria.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: September 13, 2016
    Assignee: Carnegie Mellon University
    Inventors: Adam D. Linstedt, Somshuvra Mukhopadhyay
  • METHODS AND COMPOSITIONS FOR REDUCING SHIGA TOXIN INDUCED TOXICITY IN MAMMALS
    Publication number: 20140127324
    Abstract: Manganese compositions effective in reducing Shiga toxin-induced toxicity in mammals infected with Shiga toxin-producing bacteria such as E. coli O157:H7 are described. Manganese compositions described herein can be combined with antibiotic therapy as manganese can block the toxic effects of Shiga toxin released from dying bacteria.
    Type: Application
    Filed: January 18, 2012
    Publication date: May 8, 2014
    Applicant: CARNEGIE MELLON UNIVERSITY
    Inventors: Adam D. Linstedt, Somshuvra Mukhopadhyay