Abstract: The present invention is related to the development of novel compounds and methods for the treatment and/or prevention of malaria. The compounds prevent the formation by the malaria parasite of the plasmodium surface anion channel (PSAC) on the surface of the host cell. The compounds and methods described herein are effective against infection by a wide variety of Plasmodia strains known as the causative agent of malaria.

Abstract: A prosthetic heart valve includes an annular frame that is radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration. The frame has a plurality of circumferentially extending rows of angled struts, each row of angled struts comprising angled struts arranged in a zig-zag pattern. The prosthetic heart valve further includes a leaflet structure positioned within the frame and secured thereto, and an outer sealing member mounted outside of the frame. The sealing member has an undulating outflow edge portion forming a plurality of triangular projections that are connected to and shaped to correspond to the zig-zag pattern of one of the rows of angled struts. The outer sealing member is sized to fit snugly against the outer surface of the frame when the frame is in the expanded configuration.

Abstract: A Real-Time Protocol (RTP) source node of a network operates to send a first data packet of a first size to a destination node over a path of the network that includes a plurality of intermediate nodes, at least one of the intermediate nodes having a maximum transmission unit (MTU) size smaller than the first size such that fragmentation of the first data packet occurs. The destination node sends back to the source node a RTCP report that includes a number of fragments received and a largest minimum data packet size. In response, the source node sends subsequent data packets having a second size less than or equal to the largest data packet size of the fragments. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: A technique is disclosed for selectively adjusting the power and/or frequency of cable modems without relying solely on the most recent measurement of these values to determine whether a change is necessary. Rather, it considers multiple recent measurements and from these makes its assessment. In one approach, the technique employs an average of the recent measurements to determine whether a change in power or frequency is necessary. There are actually at least three determinations that can make use of multiple recent measurements. These include (1) determining whether the signals are fluctuating to an extent that requires a special adjustment technique, (2) determining whether an adjustment is necessary (using the special technique), and (3) determining how large of an adjustment is necessary.