Patents by Inventor Sonal Tonapi

Sonal Tonapi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DESIGN AND SELECTION OF AFFINITY REAGENTS
    Publication number: 20240344240
    Abstract: Methods and systems are provided herein for selecting an affinity reagent which binds a desired peptide epitope in a plurality of sequence contexts. The method relies on obtaining a peptide library, each peptide having the sequence ?X?, wherein X is the desired peptide epitope, wherein each of ? and ? comprise an amino acid, using the peptide library to select an affinity reagent.
    Type: Application
    Filed: March 19, 2024
    Publication date: October 17, 2024
    Inventors: Joshua S. KLEIN, Jarrett EGERTSON, Tracy CHAN, Sonal TONAPI, Parag MALLICK, Minyong CHUNG, Abdullah OZER, Elliott SORELLE, David STERN
  • Affinity reagents having enhanced binding and detection characteristics
    Patent number: 11993807
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: May 28, 2024
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • Selection of affinity reagents
    Patent number: 11993865
    Abstract: Methods and systems are provided herein for selecting an affinity reagent which binds a desired peptide epitope in a plurality of sequence contexts. The method relies on obtaining a peptide library, each peptide having the sequence ?X?, wherein X is the desired peptide epitope, wherein each of ? and ? comprise an amino acid, using the peptide library to select an affinity reagent.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: May 28, 2024
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Joshua S. Klein, Jarrett Egertson, Tracy Chan, Sonal Tonapi, Parag Mallick, Minyong Chung, Abdullah Ozer, Elliott Sorelle, David Stern
  • GENERATION AND SELECTION OF AFFINITY REAGENTS
    Publication number: 20240093270
    Abstract: The present disclosure provides methods, compositions and apparatus for generating probes having affinity for analytes of interest, such as polypeptides. Also provided are methods, compositions and apparatus for evaluating and characterizing probes.
    Type: Application
    Filed: August 10, 2023
    Publication date: March 21, 2024
    Inventors: Aimee SANFORD, Ahana DUTTA, Tanvir SAINI, Wade DUGDALE, Marina KOVALIOV, Kaitlyn BURKE, Filip BARTNICKI, Tural AKSEL, Sonal TONAPI, Parag MALLICK
  • AFFINITY REAGENTS HAVING ENHANCED BINDING AND DETECTION CHARACTERISTICS
    Publication number: 20240018574
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Application
    Filed: June 2, 2023
    Publication date: January 18, 2024
    Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua Simon KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
  • AFFINITY REAGENTS HAVING ENHANCED BINDING AND DETECTION CHARACTERISTICS
    Publication number: 20230272459
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Application
    Filed: March 7, 2023
    Publication date: August 31, 2023
    Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua Simon KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
  • Affinity reagents having enhanced binding and detection characteristics
    Patent number: 11692217
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: July 4, 2023
    Assignee: Nautilus Subsidiary, Inc.
    Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
  • DESIGN AND SELECTION OF AFFINITY AGENTS
    Publication number: 20230107579
    Abstract: Methods and systems are provided herein for selecting an affinity reagent which binds a desired peptide epitope in a plurality of sequence contexts. The method relies on obtaining a peptide library, each peptide having the sequence ?X?, wherein X is the desired peptide epitope, wherein each of ? and ? comprise an amino acid, using the peptide library to select an affinity reagent.
    Type: Application
    Filed: November 20, 2019
    Publication date: April 6, 2023
    Inventors: Josh KLEIN, Jarrett EGERTSON, Tracy CHAN, Sonal TONAPI, Parag MALLICK, Minyong CHUNG, Abdullah OZER, Elliott SORELLE, David STERN
  • AFFINITY REAGENTS HAVING ENHANCED BINDING AND DETECTION CHARACTERISTICS
    Publication number: 20220162684
    Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.
    Type: Application
    Filed: November 10, 2021
    Publication date: May 26, 2022
    Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
  • TARGETED OLIGONUCLEOTIDES
    Publication number: 20190359983
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a member of a ribonucleoprotein or spliceosomal complex such heterologous nuclear ribonucleoprotein U (hnRNP U).
    Type: Application
    Filed: February 2, 2018
    Publication date: November 28, 2019
    Inventors: Heather O'Neill, Günter Mayer, Sonal Tonapi, Vaishali Pannu, Mark Miglarese, David Spetzler