Abstract: Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion. This limits their use as a therapeutic delivery agent. Increasing the surface negative charge of SUVs, via the attachment of anionic entities such as DNA/RNA, increases the colloidal stability of these vesicles. Additionally, the dense spherical arrangement and radial orientation of nucleic acids exhibits unique chemical and biological properties, unlike their linear counterparts. These liposomal particles, are non-toxic and though anionic, can efficiently enter cells without the aid of ancillary cationic transfection agents in a non-immunogenic fashion. These exceptional properties allow their use as delivery agents for gene regulation in different therapies and offer an alternative platform to metal core spherical nucleic acids.

Abstract: A catalyst composition comprising (a) a manganese-containing compound and (b) a carboxylic acid functionalized metal organic framework (MOF) compound; and a process for preparing an olefin oxide compound product including reacting (a) at least one olefin compound with (b) at least one oxidant in the presence of (c) the above catalyst composition.

Abstract: Methods of preparing spherical nucleic acids using thermoresponsive traceless templates, such as PEO-PPO-PEO block copolymers.

Abstract: Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion. This limits their use as a therapeutic delivery agent. Increasing the surface negative charge of SUVs, via the attachment of anionic entities such as DNA/RNA, increases the colloidal stability of these vesicles. Additionally, the dense spherical arrangement and radial orientation of nucleic acids exhibits unique chemical and biological properties, unlike their linear counterparts. These liposomal particles, are non-toxic and though anionic, can efficiently enter cells without the aid of ancillary cationic transfection agents in a non-immunogenic fashion. These exceptional properties allow their use as delivery agents for gene regulation in different therapies and offer an alternative platform to metal core spherical nucleic acids.

Abstract: This disclosure related to modular and programmable peptide-oligonucleotide chimeras comprising of peptide and oligonucleotide segments interlinked by an organic core are presented and their assembly as morphologically-tunable soft materials, for example, nanostructure compositions comprising a plurality of compounds comprising a peptide segment and an oligonucleotide segment interlinked by an organic core moiety.

Abstract: A catalyst composition comprising (a) a manganese-containing compound and (b) a carboxylic acid functionalized metal organic framework (MOF) compound; and a process for preparing an olefin oxide compound product including reacting (a) at least one olefin compound with (b) at least one oxidant in the presence of (c) the above catalyst composition.

Abstract: A catalyst composition comprising (a) a manganese-containing compound and (b) a carboxylic acid functionalized metal organic framework (MOF) compound; and a process for preparing an olefin oxide compound product including reacting (a) at least one olefin compound with (b) at least one oxidant in the presence of (c) the above catalyst composition.

Abstract: Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion. This limits their use as a therapeutic delivery agent. Increasing the surface negative charge of SUVs, via the attachment of anionic entities such as DNA/RNA, increases the colloidal stability of these vesicles. Additionally, the dense spherical arrangement and radial orientation of nucleic acids exhibits unique chemical and biological properties, unlike their linear counterparts. These liposomal particles, are non-toxic and though anionic, can efficiently enter cells without the aid of ancillary cationic transfection agents in a non-immunogenic fashion. These exceptional properties allow their use as delivery agents for gene regulation in different therapies and offer an alternative platform to metal core spherical nucleic acids.

Abstract: Provided herein are small unilaminar vesicles with surface-displayed polymer moieties, and methods of use and manufacture thereof. In particular, provided herein are polymer-grafted nanobins, and methods of drug delivery therewith.

Abstract: A catalyst composition comprising (a) a manganese-containing compound and (b) a carboxylic acid functionalized metal organic framework (MOF) compound; and a process for preparing an olefin oxide compound product including reacting (a) at least one olefin compound with (b) at least one oxidant in the presence of (c) the above catalyst composition.

Abstract: Embodiments include selective adsorbents having a structure of Formula (I) where a connection to X represents a connection to a structure of Formula (II), and a connection to Y represents a connection to a structure of Formula (III), where each R1 is independently selected from the group consisting of fluorine, chlorine, bromine, and iodine, and each R2 is independently selected from the group consisting of a hydrogen, an alkyl, an aryl, and a trisubstitutedsilyl group.

Abstract: A macroscale, self-supporting, composite laminate sheet includes individual, layered graphene oxide sheets and a polymer in spaces between the sheets. This composite product can be fabricated by combining a suspension of individual graphene oxide sheets and a solution of polymer, passing the resulting fluid through a fluid-permeable support, and assembling the graphene oxide sheets and polymer as a laminate sheet by flow-directed assembly. The laminate is dried and released from the membrane filter as a self-supporting thin films.

Abstract: Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed-of the formula where M is Os or Ru; R1 is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X1 are independently selected from any anionic ligand; and L and L1 are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors. The ruthenium and osmium carbene compounds may be used to catalyze olefin metathesis reactions.

Abstract: Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The carbene compounds are of the formula where M is Os or Ru; R1 is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X1 are independently selected from any anionic ligand; and L and L1 are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors.

Abstract: Composite polymer films or layers have graphene-based nanosheets dispersed in the polymer for the reduction of gas permeability and light transmittance.

Abstract: A ceramic composite thin film or layer includes individual graphene oxide and/or electrically conductive graphene sheets dispersed in a ceramic (e.g. silica) matrix. The thin film or layer can be electrically conductive film or layer depending the amount of graphene sheets present. The composite films or layers are transparent, chemically inert and compatible with both glass and hydrophilic SiOx/silicon substrates. The composite film or layer can be produced by making a suspension of graphene oxide sheet fragments, introducing a silica-precursor or silica to the suspension to form a sol, depositing the sol on a substrate as thin film or layer, at least partially reducing the graphene oxide sheets to conductive graphene sheets, and thermally consolidating the thin film or layer to form a silica matrix in which the graphene oxide and/or graphene sheets are dispersed.

Abstract: Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed-of the formula where M is Os or Ru; R1 is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X1 are independently selected from any anionic ligand; and L and L1 are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors. The ruthenium and osmium carbene compounds may be used to catalyze olefin metathesis reactions.

Abstract: A macroscale, self-supporting, composite laminate sheet includes individual, layered graphene oxide sheets and a polymer in spaces between the sheets. This composite product can be fabricated by combining a suspension of individual graphene oxide sheets and a solution of polymer, passing the resulting fluid through a fluid-permeable support, and assembling the graphene oxide sheets and polymer as a laminate sheet by flow-directed assembly. The laminate is dried and released from the membrane filter as a self-supporting thin films.

Abstract: Composite polymer films or layers have graphene-based nanosheets dispersed in the polymer for the reduction of gas permeability and light transmittance.

Abstract: A method of making a dispersion of reduced graphite oxide nanoplatelets involves providing a dispersion of graphite oxide nanoplatelets and reducing the graphite oxide nanoplatelets in the dispersion in the presence of a reducing agent and a polymer. The reduced graphite oxide nanoplatelets are reduced to an extent to provide a higher C/O ratio than graphite oxide. A stable dispersion having polymer-treated reduced graphite oxide nanoplatelets dispersed in a dispersing medium, such as water or organic liquid is provided. The polymer-treated, reduced graphite oxide nanoplatelets can be distributed in a polymer matrix to provide a composite material.