Patents by Inventor Sondre Nilsen

Sondre Nilsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOTA synthesis
    Patent number: 10941124
    Abstract: The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 9, 2021
    Assignee: GE HEALTHCARE AS
    Inventors: Andreas Richard Meijer, Arne Wang Aabye, Khalid Hussain, Sondre Nilsen, Mikkel Jacob Thaning, Jarle Andre Haugan, Ingvil Gausemel, Nikolai Enes, Silalahi Sumihar
  • Crystallization process of tricyclic indole derivatives
    Patent number: 10709798
    Abstract: A composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties, particularly when said compound is destined for use in vivo as a therapeutic or diagnostic agent.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: July 14, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Sondre Nilsen, Srinath Balaji Aralikatti Prahladachar Balaji, Umamaheshwar P. Mokkapati, Afsal Mohammed Kadavilpparampu Mohamed
  • DOTA SYNTHESIS
    Publication number: 20180370925
    Abstract: The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 27, 2018
    Applicant: GE Healthcare AS
    Inventors: Andreas Richard Meijer, Arne Wang Aabye, Khalid Hussain, Sondre Nilsen, Mikkel Jacob Thaning, Jarle Andre Haugan, Ingvil Gausemel, Nikolai Enes, Silalahi Sumihar
  • Enantiomeric separation and purification of 2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid amide derivatives
    Patent number: 9815785
    Abstract: A method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: November 14, 2017
    Assignee: GE Healthcare Limited
    Inventors: Sondre Nilsen, Dimitrios Mantzilas
  • Zinc halide mediated cyclization process leading to tricyclic indoles
    Patent number: 9475769
    Abstract: The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: October 25, 2016
    Assignee: GE Healthcare Limited
    Inventors: Sondre Nilsen, Umamaheshwar P. Mokkapati
  • ENANTIOMERIC SEPARATION AND PURIFICATION OF 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-4-CARBOXYLIC ACID AMIDE DERIVATIVES
    Publication number: 20160168091
    Abstract: A method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds.
    Type: Application
    Filed: July 17, 2014
    Publication date: June 16, 2016
    Inventors: Sondre NILSEN, Dimitrios MANTZILAS
  • CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES
    Publication number: 20150335766
    Abstract: A composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties, particularly when said compound is destined for use in vivo as a therapeutic or diagnostic agent.
    Type: Application
    Filed: November 28, 2013
    Publication date: November 26, 2015
    Inventors: Sondre NILSEN, Srinath Balaji Aralikatti Prahladachar Balaji, Umamaheshwar P. MOKKAPATI, Afsal, Mohammed KADAVILPPARAMPU, MOHAMED
  • Zinc Halide Mediated Cyclization Process Leading to Tricyclic Indoles
    Publication number: 20150336891
    Abstract: The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.
    Type: Application
    Filed: November 29, 2013
    Publication date: November 26, 2015
    Applicant: GE Healthcare Limited
    Inventors: Sondre Nilsen, Umamaheshwar P. Mokkapati
  • Purification of precursor compound by crystallisation
    Patent number: 9061977
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: June 23, 2015
    Assignee: GE Healthcare Limited
    Inventors: Anne Nilsen, Sondre Nilsen
  • Precursor compounds and methods for making same
    Patent number: 8946483
    Abstract: The present invention relates to a method of obtaining radiopharmaceutical precursors, and in particular precursors to protected amino acid derivatives, which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures, such as positron emission tomography (PET).
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 3, 2015
    Assignee: GE Healthcare Limited
    Inventors: Radha Achhanath, Srinath Balaji, Asfal Mohammed Kadavilpparampu Mohamed, Sondre Nilsen, Steven Michael Fairway
  • PRECURSOR COMPOUNDS AND METHODS FOR MAKING SAME
    Publication number: 20140135531
    Abstract: The present invention relates to a method of obtaining radiopharmaceutical precursors, and in particular precursors to protected amino acid derivatives, which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures, such as positron emission tomography (PET).
    Type: Application
    Filed: July 20, 2012
    Publication date: May 15, 2014
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Radha Achhanath, Srinath Balaji, Asfal Mohammed Kadavilpparampu Mohamed, Sondre Nilsen, Steven Michael Fairway
  • PURIFICIATION OF PRECURSOR COMPOUND BY CRYSTALLISATION
    Publication number: 20130267730
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.
    Type: Application
    Filed: December 19, 2011
    Publication date: October 10, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Anne Nilsen, Sondre Nilsen