Abstract: The disclosure provides to CRISPR/Cas systems and compositions which target the dystrophin gene. Also provided are methods for using the CRISPR/Cas systems, vectors and compositions in methods for genome engineering to correct a mutant dystrophin gene, and for treating Duchenne muscular dystrophy.

Abstract: The invention relates to self-inactivating/self-targeting CRISPR/Cas or CRISPR/Cpf1 systems. The invention also relates to genetically modified cells related to the same. The invention also relates to methods of controlling Cas9 expression in a cell related to the same. The invention also relates to methods of genetically modifying a cell related to the same. The invention also relates to nucleic acids for use in a self-inactivating CRISPR/Cas or CRISPR/Cpf1 system. The invention also relates to pharmaceutical compositions related to the same.

Abstract: A technique for providing high-contrast images of defects in solar cells and solar panels, by illuminating each cell under inspection with broadband infrared radiation, and then forming an image of radiation that is secularly reflected from the cell. Multi-junction solar cells have a metal backing layer that secularly reflects the illumination back into an appropriately positioned and aligned camera, selected to be sensitive to infrared wavelengths at which the solar cell materials are relatively transparent.

Abstract: A coolant delivery system of an apparatus in one example creates a layer of coolant over a target area. The target area comprises at least one carious region. A laser generator of the apparatus directs a laser beam to the target area to ablate the at least one carious region. The laser generator operates substantially simultaneously with the coolant delivery system to direct the laser beam through the layer of coolant to the target area. The layer of coolant cools the target area to reduce thermal damage from the laser beam.

Abstract: A technique for providing high-contrast images of defects in semiconductor devices and arrays of such devices, by illuminating each semiconductor device under inspection with broadband infrared radiation, and then forming an image of radiation that is specularly reflected from the semiconductor device. Many semiconductor devices and arrays of such devices have a metal backing layer that specularly reflects the illumination back into an appropriately positioned and aligned camera, selected to be sensitive to infrared wavelengths at which the semiconductor device materials are relatively transparent.

Abstract: Method and apparatus of manufacturing color metal zipper are disclosed. The method includes washing half-finished metal zipper; overlaying a thin film on the upper surface of half-finished metal zipper; feeding color transfer paper; overlaying the half-finished metal zipper on the color transfer paper and positioning same; intermittently advancing the overlaid half-finished metal zipper and the color transfer paper; heating and pressing the overlaid half-finished metal zipper and the color transfer paper in an interval when the advancing stops for uniformly transferring color of the color transfer paper to a portion of the half-finished metal zipper; intermittently advancing the half-finished metal zipper and the color transfer paper again; separating the finished color metal zipper from the color transfer paper while intermittently advancing; and cooling and storing the finished color metal zipper and color transfer paper.

Abstract: A zipper having its tab or slide incorporating an RFID device is disclosed. The RFID device includes an IC disposed on a central portion of a recess of the tab or slide, an antenna in the form of a plurality of closely engaged concentric miniature enamelled wire conductors secured on a zone defined between projections spaced around a center of the recess and a peripheral flange of the recess, and two connections each electrically interconnected the IC and the antenna. In one embodiment, the tab has a ring for putting on an object. The concealed RFID device can be protected. Also, it may not detract from the zipper's external appearance.

Abstract: A method for remote analysis of materials embedded in a frozen surface, such as in the icy surface of a planetary body. A laser on board a spacecraft irradiates the frozen surface and thereby releases materials in a gas cloud, by a process of desorption. The laser wavelength is selected to maximize the release of substances by the desorption process, which does not fragment materials into their elemental components. An infrared (IR) spectrometer on the spacecraft detects thermal emissions from the gas cloud against a background provided by the frozen surface, and can readily identify a variety of organic, inorganic and biological materials from their thermal spectra.

Abstract: A technique for providing high-contrast images of defects in semiconductor devices and arrays of such devices, by illuminating each semiconductor device under inspection with broadband infrared radiation, and then forming an image of radiation that is specularly reflected from the semiconductor device. Many semiconductor devices and arrays of such devices have a metal backing layer that specularly reflects the illumination back into an appropriately positioned and aligned camera, selected to be sensitive to infrared wavelengths at which the semiconductor device materials are relatively transparent.

Abstract: A technique for providing high-contrast images of defects in solar cells and solar panels, by illuminating each cell under inspection with broadband infrared radiation, and then forming an image of radiation that is secularly reflected from the cell. Multi-junction solar cells have a metal backing layer that secularly reflects the illumination back into an appropriately positioned and aligned camera, selected to be sensitive to infrared wavelengths at which the solar cell materials are relatively transparent.

Abstract: Method and apparatus of manufacturing color plastic zipper are disclosed. The method includes feeding a continuous row of half-finished plastic zipper, feeding a continuous strip of color transfer film, overlaying the half-finished plastic zipper and the color transfer film and positioning same, intermittently advancing the overlaid half-finished plastic zipper and the color transfer film, heating and pressing the overlaid half-finished plastic zipper and the color transfer film in an interval when the advancing stops for uniformly transferring color of the color transfer film to a portion of the half-finished plastic zipper, advancing the half-finished plastic zipper and the color transfer film again, separating the finished color plastic zipper from the color transfer film while intermittently advancing, and cooling the finished color plastic zipper and the color transfer film. The invention has advantages of high efficiency, high yield, and having a low manufacturing cost.

Abstract: A method for remote analysis of materials embedded in a frozen surface, such as in the icy surface of a planetary body. A laser on board a spacecraft irradiates the frozen surface and thereby releases materials in a gas cloud, by a process of desorption. The laser wavelength is selected to maximize the release of substances by the desorption process, which does not fragment materials into their elemental components. An infrared (IR) spectrometer on the spacecraft detects thermal emissions from the gas cloud against a background provided by the frozen surface, and can readily identify a variety of organic, inorganic and biological materials from their thermal spectra.

Abstract: An indoor air circulation sterilizing device is provided. The sterilizing device is installed to a return air inlet on the ceiling. The sterilizing device includes a frame body, at least three separator plates and a sterilizing lamp set. The frame body is composed of a first frame and a second frame. The first frame includes a plurality of containing grooves intermittently disposed thereon. The containing grooves can provide the separator plates to be disposed thereon. Several penetrating holes are formed on the separator plates. Each two adjacent separator plates are so disposed that the penetrating holes are mutually shifted. The sterilizing lamp set is disposed on the separator plates and is connected with the frame body. Therefore, there is provided a longer path for air to flow in the separator plates with a slower flowing speed, thereby sterilizing the bacteria in the air by employing the sterilizing lamp set.

Abstract: A mobile disinfection apparatus is provided to disinfect the sickbeds. The disinfection apparatus includes a retractable hollow shield with a plurality of wheels for enclosing the sickbed thereinside; a disinfector furnished on an inner surface of the shield for disinfecting the sickbed; and a control unit with a control panel located outside the shield for activating the disinfector.

Abstract: A system for detecting and analyzing chemical and biological materials in a sample. The system includes a spectrometer for passively receiving emissions from the sample in the terahertz frequency band to detect the materials therein. A telescope or other device can be used to confine the field-of-view of the spectrometer. A cold surface is positioned filling the field-of-view of the spectrometer at an opposite side of the sample from the spectrometer. The cold surface provides a low temperature background relative to the sample so as to reduce the background emission and enhance the detection of the emission from the sample.

Abstract: A system for detecting and analyzing chemical and biological aerosols. A beam of radiation is used to radiate a target cloud including the aerosol. The radiation energy that is absorbed by the cloud is thermalized by collisional energy transfer between the molecules that absorb the radiation to generate heat. The wavelength of the electromagnetic radiation is selected to be in resonance with the absorption lines of water or oxygen molecules in the cloud, or to be in resonance with absorption lines of known target molecules in the cloud to generate the heat. An increase in the cloud temperature increases the emission intensity of the molecules against the background, resulting in improved detection of the target molecules in the aerosol. A tracking telescope collects the thermal emissions generated by the radiation beam. A spectrometer receives the emissions from the cloud and generates an emission spectrum.

Abstract: A system (10) for detecting and analyzing chemical and biological constituents in a sample (12). The system (10) includes a spectrometer (18) for passively receiving emissions (22) from the sample (12) to detect the constituents therein. A telescope (58) and/or other optical device (70) is used to confine the field-of-view of the spectrometer (18). A cold device (28) is positioned within the field-of-view of the spectrometer (18) at an opposite side of the sample (12) from the spectrometer (18). The cold device (28) provides a low temperature background relative to the sample (12) so as to increase the emissions (22) from the sample (12) and also to reduce the background emission.

Abstract: A system for the remote detection and analysis of trace chemical agents in the air. A beam of electromagnetic radiation is used to radiate a cloud. The radiation energy that is absorbed by the cloud is thermalized by collisional energy transfer between the molecules that absorb the radiation. Increases in the cloud temperature increase the emission intensity of the molecules against the background, resulting in improved detection of the target molecules. A tracking telescope is used to collect the thermal emissions generated by the radiation beam. A spectrometer is used to resolve the emissions from the cloud and generate an emissions spectrum. The wavelength of the electromagnetic radiation can be selected to be in resonance with the absorption lines of water or oxygen molecules in the cloud, or to be in resonance with absorption lines of known target molecules in the cloud to generate the heat.

Abstract: A system for the remote detection and analysis of trace chemical agents in the air. A beam of electromagnetic radiation is used to radiate a cloud. The radiation energy that is absorbed by the cloud is thermalized by collisional energy transfer between the molecules that absorb the radiation. Increases in the cloud temperature increase the emission intensity of the molecules against the background, resulting in improved detection of the target molecules. A tracking telescope is used to collect the thermal emissions generated by the radiation beam. A spectrometer is used to resolve the emissions from the cloud and generate an emissions spectrum. The wavelength of the electromagnetic radiation can be selected to be in resonance with the absorption lines of water or oxygen molecules in the cloud, or to be in resonance with absorption lines of known target molecules in the cloud to generate the heat.

Abstract: Non-invasive measurement of blood glucose is achieved by transmitting a ring of electromagnetic radiation to the surface of a subject (S) by a ring illuminator (22). The radiation diffuses into the subject illuminated and emits a portion of the radiation in area (E2) displaced from the illuminated area. A CCD camera (40) collects at least a portion of the emitted radiation and generates detection signals which are processed by a processor (100) in order to measure blood glucose concentration. The processing may be synchronized with the heart beat of the subject by an electrocardiogram (74).