Abstract: A non-isolated resonant gate drive circuit includes a PMOS drive network, an NMOS clamping circuit and an inductor. The PMOS drive network and the NMOS clamping circuit are connected in parallel to two terminals of the inductor. Input signals of the PMOS drive network are provided by a function generator connected to a drive chip, drive signals are output via an output port vgsr1 and an output port vgsr2 after the input signals are processed by the PMOS drive network, the NMOS clamping circuit and the inductor, the NMOS clamping circuit is used for controlling the state of the output port vgsr1 and the output port vgsr2 to change, and the inductor forms LC resonance together with a gate capacitor Cgsr1 and a gate capacitor Cgsr2 in the NMOS clamping circuit to recover energy in a process of turning off the drive circuit.

Abstract: A non-isolated resonant gate drive circuit includes a PMOS drive network, an NMOS clamping circuit and an inductor. The PMOS drive network and the NMOS clamping circuit are connected in parallel to two terminals of the inductor. Input signals of the PMOS drive network are provided by a function generator connected to a drive chip, drive signals are output via an output port vgsr1 and an output port vgsr2 after the input signals are processed by the PMOS drive network, the NMOS clamping circuit and the inductor, the NMOS clamping circuit is used for controlling the state of the output port vgsr1 and the output port vgsr2 to change, and the inductor forms LC resonance together with a gate capacitor Cgsr1 and a gate capacitor Cgsr2 in the NMOS clamping circuit to recover energy in a process of turning off the drive circuit.

Abstract: An earbud device, including: an earbud, where the earbud includes a housing and a movable part, the housing is provided with an accommodation chamber with an opening, a first charging contact is provided on the movable part, the first charging contact avoids the opening of the accommodation chamber when the movable part is at a first position, and the first charging contact is exposed at the opening of the accommodation chamber when the movable part is at a second position; and an earbud case, where the earbud case is provided with an accommodation groove, a second charging contact is provided in the accommodation groove, a driving part is arranged in the earbud case, the driving part drives the movable part to move from the first position to the second position during a process that the earbud is placed into the accommodation groove.

Abstract: A lossless exciting current sampling circuit for an isolated converter includes first and second voltage sampling circuits and a subtraction circuit formed by an operational amplifier. The two sampling circuits sample voltages of the primary winding of an isolation transformer, with outputs fed into the subtracter. The subtracter output is the circuit's output. RC low-pass filters with large time constants are used as primary voltage sampling circuits, realizing integration of voltage differences between the exciting inductance terminals, enabling lossless current sampling without resistors or transformers. The current sampling result is utilized for volt-second balance control, realized along with a hold circuit and comparator which compares the sampling hold result with the current sampling result to generate a control signal.

Abstract: A robot control method, including: determining a target operation map according to target position information of a current operation of a robot; determining, based on a pre-established map connection relationship, a transfer position that the robot moves to; controlling the robot to move to the transfer position and switching maps, until the robot moves to the target operation map; and controlling the robot to move to an operation destination according to map information of the target operation map and the target position information.

Abstract: A drilling device for geotechnical engineering investigation is provided, including an outer supporting ring seat, where a center of the outer supporting ring seat is rotatably connected with a middle supporting ring seat through a first supporting shaft rod; a center of the middle supporting ring seat is rotatably connected with an inner supporting ring seat through a second supporting shaft rod; the first supporting shaft rod and the second supporting shaft rod are vertically crossed; a second rotating motor is fixedly installed at one end of the first supporting shaft rod on an outer surface of the outer supporting ring seat; a pow output end of the second rotating motor is fixedly connected with the first supporting shaft rod, an other end of the first supporting shaft rod is provided with a first locking mechanism for position limitation.

Abstract: An image collection method and apparatus, and an electronic device are provided. The electronic device includes: a housing provided with a light transmission hole and an opening, where the light transmission hole and the opening are respectively disposed on adjacent first and second sides of the housing; a camera module including a first camera module and a second camera module disposed in the housing; and a driving mechanism connected to the camera module and configured to drive the camera module to move between a first position and a second position. When the camera module is located at the first position, the first camera is opposite to the light transmission hole. When the camera module is located at the second position, the first camera at least partially extends out of the housing from the opening. The second camera is opposite to the light transmission hole.

Abstract: A drilling device for geotechnical engineering investigation is provided, including an outer supporting ring seat, where a center of the outer supporting ring seat is rotatably connected with a middle supporting ring seat through a first supporting shaft rod; a center of the middle supporting ring seat is rotatably connected with an inner supporting ring seat through a second supporting shaft rod; the first supporting shaft rod and the second supporting shaft rod are vertically crossed; a second rotating motor is fixedly installed at one end of the first supporting shaft rod on an outer surface of the outer supporting ring seat; a pow output end of the second rotating motor is fixedly connected with the first supporting shaft rod, an other end of the first supporting shaft rod is provided with a first locking mechanism for position limitation.

Abstract: An image collection method and apparatus, and an electronic device are provided. The electronic device includes: a housing provided with a light transmission hole and an opening, where the light transmission hole and the opening are respectively disposed on adjacent first and second sides of the housing; a camera module including a first camera module and a second camera module disposed in the housing; and a driving mechanism connected to the camera module and configured to drive the camera module to move between a first position and a second position. When the camera module is located at the first position, the first camera is opposite to the light transmission hole. When the camera module is located at the second position, the first camera at least partially extends out of the housing from the opening. The second camera is opposite to the light transmission hole.

Abstract: This invention relates to use of a platinum-acridine liposomal formulation and uses thereof in treating cancer in a subject.

Abstract: This invention relates to use of a platinum-acridine liposomal formulation and uses thereof in treating cancer in a subject.

Abstract: The present invention relates to using a versatile synthetic approach to generate a new class of ester, amido, or carbamate prodrugs of highly potent, but systemically too toxic, platinum-acridine anticancer agents. The new hybrids contain a hydroxyl group, which has been masked with a cleavable lipophilic acyl moiety. Both butanoic (butyric) and bulkier 2-propanepentanoic (valproic) esters were introduced to these compounds. The goal of this design was to improve the drug-like properties of the pharmacophore (e. g., log D) without compromising its DNA-mediated cell kill potential. Two distinct pathways by which the target compounds undergo effective ester hydrolysis, the proposed activating step, have been confirmed: platinum-mediated, self-immolative ester cleavage in a low-chloride environment (LC-ESMS, NMR spectroscopy) and enzymatic cleavage by human carboxylesterase-2 (hCES-2) (LC-ESMS).

Abstract: The present invention relates to using a versatile synthetic approach to generate a new class of ester, amido, or carbamate prodrugs of highly potent, but systemically too toxic, platinum-acridine anticancer agents. The new hybrids contain a hydroxyl group, which has been masked with a cleavable lipophilic acyl moiety. Both butanoic (butyric) and bulkier 2-propanepentanoic (valproic) esters were introduced to these compounds. The goal of this design was to improve the drug-like properties of the pharmacophore (e.g., log D) without compromising its DNA-mediated cell kill potential. Two distinct pathways by which the target compounds undergo effective ester hydrolysis, the proposed activating step, have been confirmed: platinum-mediated, self-immolative ester cleavage in a low-chloride environment (LC-ESMS, NMR spectroscopy) and enzymatic cleavage by human carboxylesterase-2 (hCES-2) (LC-ESMS).

Abstract: Acridine containing cisplatin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective cisplatin compounds to the nucleus in cancer cells is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C1-6alkylene-phenyl-NH—C(O)—R15, folic acid, ?v?3 integrin RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and/or mixtures thereof; wherein R15 is a peptide.

Abstract: Acridine containing cisplatin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective cisplatin compounds to the nucleus in cancer cells is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C1-6alkylene-phenyl-NH—C(O)—R15, folic acid, ?v?3 integrin RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and/or mixtures thereof; wherein R15 is a peptide.