Abstract: The present disclosure provides a substituted piperidine compound of Chemical Formula 1, or a pharmaceutically acceptable salt thereof having activity of degrading androgen receptor (AR). The present disclosure also provides a composition comprising such a substituted piperidine compound or a pharmaceutically acceptable salt thereof. The present disclosure also provides a medical use of a substituted piperidine compound according to the present disclosure, a salt thereof, and a composition comprising the same for the treatment or prophylaxis of AR-related diseases. The present disclosure also provides a method for treating or preventing an AR-related disease comprising administering to a subject in need thereof an effective amount of a substituted piperidine compound according to the present disclosure, a salt thereof, or a composition comprising the same.

Abstract: A method of generating an image according to the present invention includes receiving a specific content selected from a user terminal among a plurality of contents provided from a content providing service, specifying a source image based on the selected specific content, generating a resulting image using the source image and a drawing style of the specific content, and providing the resulting image to the user terminal.

Abstract: The present disclosure provides a substituted piperidine compound of Chemical Formula 1, wherein X is CR3, or a pharmaceutically acceptable salt thereof having activity of degrading androgen receptor (AR). The present disclosure also provides a composition comprising such a substituted piperidine compound or a pharmaceutically acceptable salt thereof. The present disclosure also provides a medical use of a substituted piperidine compound according to the present disclosure, a salt thereof, and a composition comprising the same for the treatment or prophylaxis of AR-related diseases. The present disclosure also provides a method for treating or preventing an AR-related disease comprising administering to a subject in need thereof an effective amount of a substituted piperidine compound according to the present disclosure, a salt thereof, or a composition comprising the same.

Abstract: The present invention relates to a peptide ligand that specifically binds to carbonic anhydrase IX (CAIX), a peptide construct comprising the ligand, and a use thereof. The CAIX-binding peptide ligand of the present invention includes D-amino acids, so it is stable in the body and has high binding specificity to CAIX. And the linear or cyclic CAIX-binding peptide construct comprising the ligand can bind to CAIX with high affinity in the body. Therefore, it is useful for diagnosis, prevention, suppression or treatment of diseases mediated by CAIX.

Abstract: Disclosed are an improved guide device capable of being easily replaced for damage, and a detector having the same. The guide device includes a first plate configured to have a plurality of grooves disposed in one surface thereof; and a second plate configured to be in contact with the first plate, wherein the second plate is in contact with the first plate to separate a plurality of channels, wherein the first plate is configured so that the plurality of microdroplets pass through any one of the plurality of channels, the fluid passes through channels facing each other among the plurality of flow channels, and the microdroplets are regularly spaced apart by the fluid that is discharged from the channels facing each other.

Abstract: A carbon byproduct removal module includes: a vaporizer configured to produce vapor including oxygen atoms; a carrier gas supplier connected to the vaporizer and configured to supply carrier gas to the vaporizer, wherein the carrier gas carries the vapor to a UV-ray irradiator; and the UV-ray irradiator configured to emit ultraviolet rays to the vapor, wherein a first end of the UV-ray irradiator is connected to a first end of the vaporizer, wherein a second end of the UV-ray irradiator is attached to an exhaust module connected to a chamber in which a semiconductor manufacturing process is performed.

Abstract: A dielectric ceramic composition includes a base material main component of barium titanate and a subcomponent. A microstructure of the dielectric ceramic composition after sintering includes a first grain having a Ca content of less than 3.5 at % and a second grain having a Ca content of 3.5 to 13.5 at %, and an area ratio of the second grain to an area of the total grains is 70% to 95%.

Abstract: The present disclosure relates to a guide for mandibular resection surgery, including, a guide plate having, at its lower side, a boundary surface that guides a resection pathway of a resection saw during a mandibular resection surgery; and a fixing portion that is formed to extend from the guide plate to be combined with a mandible or tooth, thereby fixing a position of the guide plate, wherein the guide plate is foldable.

Abstract: Disclosed is a scene meta information generating apparatus including: a subtitle information generating unit configured to detect a plurality of unit subtitles based on a subtitle file related to image contents and correct the plurality of unit subtitles; an audio information generating unit configured to extract audio information from the image contents, detect a plurality of speech segments based on the audio information, and perform speech-recognition on audio information in each speech segment; and an image information generating unit configured to detect a video segment corresponding to each speech segment, perform image-recognition on image frames in the video segment, and selecting a representative image from the image frames.

Abstract: Provided are a content providing server, a content providing terminal, a content providing method. A search for image content is facilitated through a subtitle page including a unit subtitle separated by a subtitle interval, during which a subtitle is displayed in image content, and a representative image extracted from the subtitle interval in the image content, so that a user views the image content according to the user's level of understanding.

Abstract: Disclosed is a scene meta information generating apparatus including: a subtitle information generating unit configured to detect a plurality of unit subtitles based on a subtitle file related to image contents and correct the plurality of unit subtitles; an audio information generating unit configured to extract audio information from the image contents, detect a plurality of speech segments based on the audio information, and perform speech-recognition on audio information in each speech segment; and an image information generating unit configured to detect a video segment corresponding to each speech segment, perform image-recognition on image frames in the video segment, and selecting a representative image from the image frames.

Abstract: Provided are a content providing server, a content providing terminal, a content providing method. A search for image content is facilitated through a subtitle page including a unit subtitle separated by a subtitle interval, during which a subtitle is displayed in image content, and a representative image extracted from the subtitle interval in the image content, so that a user views the image content according to the user's level of understanding.

Abstract: Provided is a method and system for creating and using a video tag. A method configured as a computer may include creating tagging information by connecting information about at least one partial playback section in an entire playback section of a video to a tag designated by a user; and storing the tagging information in association with the at least one partial playback section instead of storing the at least one partial playback section.

Abstract: A method of forming a nitrogen-doped amorphous carbon layer on a substrate in a processing chamber is provided. The method generally includes depositing a predetermined thickness of a sacrificial dielectric layer over a substrate, forming patterned features on the substrate by removing portions of the sacrificial dielectric layer to expose an upper surface of the substrate, depositing conformally a predetermined thickness of a nitrogen-doped amorphous carbon layer on the patterned features and the exposed upper surface of the substrate, selectively removing the nitrogen-doped amorphous carbon layer from an upper surface of the patterned features and the upper surface of the substrate using an anisotropic etching process to provide the patterned features filled within sidewall spacers formed from the nitrogen-doped amorphous carbon layer, and removing the patterned features from the substrate.

Abstract: Provided is a spindle motor including a rotor, a stator, and a base. The rotor includes a rotor yoke, a magnet, and a rotating shaft. The stator is disposed correspondingly to the rotor and includes a core and coils. The base includes a base plate for supporting the stator. The base plate is integrally formed with a housing. The housing has the core disposed at an exterior thereof and has a bearing for rotatably supporting the rotating shaft provided within. A thrust stopper for sealing the housing is fixed to a bottom of the housing.