Abstract: The disclosure relates to insecticidal toxin resistance management and screening of novel insecticidal toxins. One embodiment relates to the isolation, characterization, compositions, and methods of use relating to polynucleotides encoding novel insecticidal toxin receptors and the polypeptides encoded thereby. The polynucleotides and polypeptides are useful in identifying or designing novel insecticidal toxin receptor ligands including novel insecticidal toxins.

Abstract: An apparatus for the removal and replacement of a lid on a metallurgical transport vessel such as a ladle or a torpedo car. The apparatus comprises a frame, means for supporting the frame such that the vessel may be moved into position thereunder, a linkage including at least one lifting member pivotally connected to the frame, and at least one actuator connected to the linkage. The actuator is operable to move the lifting member such that when the vessel is moved to a designated position below the apparatus, the lifting member can be moved by the actuator and linkage from a first position providing clearance above the vessel, through a curved path to an intermediate position where it engages the lid, providing a vertical lifting force and a horizontal hinge releasing force to the lid, and to a second position where the lid is raised to a sufficient height to clear the vessel.

Abstract: An apparatus for the removal and replacement of a lid on a metallurgical transport vessel such as a ladle or a torpedo car. The apparatus comprises a frame, means for supporting the frame such that the vessel may be moved into position thereunder, a linkage including at least one lifting member pivotally connected to the frame, and at least one actuator connected to the linkage. The actuator is operable to move the lifting member such that when the vessel is moved to a designated position below the apparatus, the lifting member can be moved by the actuator and linkage from a first position providing clearance above the vessel, through a curved path to an intermediate position where it engages the lid, providing a vertical lifting force and a horizontal hinge releasing force to the lid, and to a second position where the lid is raised to a sufficient height to clear the vessel.

Abstract: The present invention discloses the amino acid and nucleic acid sequences of a new CNGC and Myosin that map to the region of the human chromosome associated with Bardet-Biedl Syndrome. Cyclic nucleotide gated channels (CNGCs) comprise a family of multimeric protein ion channels that open in response to the binding of a cyclic nucleotide to an intracellular domain. The two new proteins, CNGC-15 and Myosin IXa, are useful in the study, diagnosis and treatment of Bardet-Biedl Syndrome and Usher Syndrome. Other indications that can be treated by CNGC-15 and/or Myosin IXa polypeptides, or agonists or antagonists include hearing loss, retinis pigmentosa, obesity, hypogonadism, sterility, polydactyly, brachydactyly, syndactyly, mental retardation, renal abnormalities, hypertension, diabetes and cardiovascular abnormalities.

Abstract: The present invention discloses the amino acid and nucleic acid sequences of a new CNGC and Myosin that map to the region of the human chromosome associated with Bardet-Biedl Syndrome. Cyclic nucleotide gated channels (CNGCs) comprise a family of multimeric protein ion channels that open in response to the binding of a cyclic nucleotide to an intracellular domain. The two new proteins, CNGC-15 and Myosin IXa, are useful in the study, diagnosis and treatment of Bardet-Biedl Syndrome and Usher Syndrome. Other indications that can be treated by CNGC-15 and/or Myosin IXa polypeptides, or agonists or antagonists include hearing loss, retinis pigmentosa, obesity, hypogonadism, sterility, polydactyly, brachydactyly, syndactyly, mental retardation, renal abnormalities, hypertension, diabetes and cardiovascular abnormalities. Compositions and methods for expressing cyclic nucleotide gated channel-15 (CNGC-15) and Myosin IXa are provided.