Abstract: An interferometric method of identifying the thickness of an object that is too thin to be resolved by a Fourier transform of the interference signal includes applying a harmonic frequency modulation to an envelope of the interference signal. Where the object is a tear film, this method may be utilized to determine a thickness of the lipid layer of the tear film.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: A frequency combination corresponding to target data to be transmitted is determined. The frequency combination includes at least two different frequencies. Ultrasonic waves of frequencies in the frequency combination are sent within a predetermined duration.

Abstract: An ophthalmologic apparatus includes: an objective lens 18 configured to face a subject's eye E; an illumination optical system 1c configured to irradiate the subject's eye E with illumination light L1; a measurement optical system 1 b configured to take an interference image of corneal reflection light R1, which is a reflection of the illumination light L1, through the objective lens 18; an observation optical system 1a configured to image an anterior segment of the subject's eye E through the objective lens 18; a control unit 2 configured to process information on imaging by the measurement optical system 1b and the observation optical system 1 a; and the control unit 2 configured to simultaneously output, to a single output unit 3, tear film information calculated from the interference image by the measurement optical system 1 b, and information on the anterior segment E imaged by the observation optical system 1a.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Abstract: Shadows caused by opacities and obstructions (such as blood vessels) can block detection of structural information of objects below the shadow-causing structure, affecting visualization and analysis of those deeper structures. An image processing method for removing these shadows includes applying a low pass filter to an energy profile of an image to remove high frequency fluctuations in energy, thereby effectively recovering lower energy inside shadow regions and removing high frequency speckle. The image is then adjusted, for example by linear scaling, based on the filtered energy profile. Two dimensional filters may also be applied for volumes.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The present application provides methods of treating PI3K? related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

Abstract: The present application provides methods of treating PI3K? related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A telemedicine data transfer system receives telemedicine data from a data source and decides whether to transmit the telemedicine data to a remote end circuit or prevent transmission of the telemedicine data to the remote end circuit based on a result of an evaluation. A telemedicine data transfer system includes image compression and decompression circuits. The decompression circuit may produce decompressed and enhanced telemedicine data. The image compression and decompression circuits include neural networks trained using an objective function to evaluate a difference between a training input data provided to the image compression circuit and a training output data that is output from the image decompression circuit. The training output data is made different from the training input data by a data enhancement operation performed on the training output data prior to the evaluation.

Abstract: An ultrasonic data transmission method, apparatus and system, a terminal device and a medium are provided. The method is applied to a transmitting terminal which includes at least two ultrasonic signal transmitting arrays. The method includes: a single-frequency ultrasonic coding signal of to-be-transmitted information corresponding to each ultrasonic signal transmitting array is respectively determined, ultrasonic codes of to-be-transmitted information corresponding to different ultrasonic signal transmitting arrays being different; and corresponding at least two single-frequency ultrasonic code signals are transmitted through the at least two ultrasonic signal transmitting arrays to a receiving terminal in a focusing mode, frequency bands of transmitting frequencies of different ultrasonic signal transmitting arrays being different.

Abstract: A method for waking up a smart device includes receiving sound information; determining whether the sound information includes a multi-frequency tone; and when the sound information includes the multi-frequency tone, waking up a preset function of the smart device based on the multi-frequency tone. A device for waking up a smart device as well as a smart device incorporating the device includes processing elements for performing the method. A non-transitory computer-readable storage medium stores computer instructions to cause processing elements to perform the method for waking up a smart device.