Patents by Inventor Songchun Jiang

Songchun Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND THERAPEUTICAL USE THEREOF
    Publication number: 20070244113
    Abstract: Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: March 1, 2007
    Publication date: October 18, 2007
    Applicants: Myriad Genetics, Incorporated, Cytovia, Inc
    Inventors: Sui Cai, Nilantha Sirisoma, Azra Pervin, John Drewe, Shailaja Kasibhatla, Songchun Jiang, Hong Zhang, Chris Pleiman, Vijay Baichwal, John Manfredi, Leena Bhoite
  • COMPOUNDS AND THERAPEUTICAL USE THEREOF
    Publication number: 20070208044
    Abstract: Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: January 5, 2007
    Publication date: September 6, 2007
    Applicant: Myriad Genetics, Incorporated
    Inventors: Sui Cai, Nilantha Sirisoma, Azra Pervin, John Drewe, Shailaja Kasibhatla, Songchun Jiang, Hong Zhang, Chris Pleiman, Vijay Baichwal, John Manfredi, Leena Bhoite
  • Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Patent number: 7235674
    Abstract: The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: June 26, 2007
    Assignee: Cytovia, Inc.
    Inventors: Sui Xiong Cai, Hong Zhang, William E. Kemnitzer, Songchun Jiang, John Drewe, Richard Storer
  • Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis
    Publication number: 20070093456
    Abstract: The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: December 17, 2004
    Publication date: April 26, 2007
    Inventors: Sui Cai, Songchun Jiang, Han-Zhong Zhang
  • Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Publication number: 20060104998
    Abstract: The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: May 16, 2003
    Publication date: May 18, 2006
    Applicant: Cytovia, Inc.
    Inventors: Sui Cai, Songchun Jiang, William Kemnitzer, Hong Zhang, Giorgio Attardo, Real Denis
  • Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Patent number: 7015328
    Abstract: The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: March 21, 2006
    Assignees: Cytovia, Inc., Shire BioChem Inc.
    Inventors: Sui Xiong Cai, Hong Zhang, William E. Kemnitzer, Songchun Jiang, John Drewe, Richard Storer
  • SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
    Publication number: 20060035925
    Abstract: The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: June 13, 2005
    Publication date: February 16, 2006
    Applicant: Cytovia, Inc.
    Inventors: Sui Cai, Hong Zhang, Songchun Jiang, Richard Storer
  • Substituted 4h-chromens, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Publication number: 20050176750
    Abstract: The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R5, A, B, X, Y, Z and dotted lines are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: May 16, 2003
    Publication date: August 11, 2005
    Inventors: Sui Cai, Songchun Jiang, Giorgio Attardo, Real Denis, Richard Storer, Rabindra Rej
  • Compounds and therapeutical use thereof
    Publication number: 20050137213
    Abstract: Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: July 6, 2004
    Publication date: June 23, 2005
    Applicant: Myriad Genetics, Incorporated
    Inventors: Sui Cai, Nilantha Sirisoma, Azra Pervin, John Drewe, Shailaja Kasibhatla, Songchun Jiang, Hong Zhang, Chris Pleiman, Vijay Baichwal, John Manfredi, Leena Bhoite
  • Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Patent number: 6900325
    Abstract: The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: May 31, 2005
    Assignees: Cytovia, Inc., Shire BioChem Inc.
    Inventors: Sui Xiong Cai, Hong Zhang, William E. Kemnitzer, Songchun Jiang, John Drewe, Richard Storer
  • Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Publication number: 20050090526
    Abstract: The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Application
    Filed: November 16, 2004
    Publication date: April 28, 2005
    Applicants: Cytovia, Inc., Shire BioChem, Inc.
    Inventors: Sui Cai, Hong Zhang, William Kemnitzer, Songchun Jiang, John Drewe, Richard Storer
  • Methods of treating diseases responsive to induction of Apoptosis and screening assays
    Publication number: 20050004026
    Abstract: The present invention pertains to a method of treating, preventing or ameliorating a disease responsive to induction of the caspase cascade in an animal, comprising administering to the animal a compound which binds specifically to one or more Apoptosis Inducing Proteins (AIPs). AIPs include Transferrin Receptor Related Apoptosis Inducing Proteins (TRRAIPs), Clathrin Heavy Chain Related Apoptosis Inducing Proteins (CHCRAIPs), IQ motif containing GTPase Activating Protein Related Apoptosis Inducing Proteins (IQGAPRAIPs), and Heat Shock Protein Related Apoptosis Inducing Proteins (HSPRAIPs). The present invention also relates to screening methods useful for drug discovery of apoptosis inducing compounds. In particular, the screening methodology relates to using AIPs as a target for the discovery of apoptosis activators useful as anticancer agents.
    Type: Application
    Filed: April 19, 2004
    Publication date: January 6, 2005
    Inventors: Shailaja Kasibhatla, Sui Cai, Ben Tseng, Katayoun Jessen, Nicole English, Serguei Maliartchouk, Songchun Jiang, Nilantha Sirisoma, Han-Zhong Zhang, Jared Kuemmerle
  • Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Publication number: 20030114485
    Abstract: The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: 1
    Type: Application
    Filed: May 16, 2002
    Publication date: June 19, 2003
    Applicant: Cytovia, Inc.
    Inventors: Sui Xiong Cai, Hong Zhang, William E. Kemnitzer, Songchun Jiang, John Drewe, Richard Storer
  • Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Publication number: 20030065018
    Abstract: The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1
    Type: Application
    Filed: May 16, 2002
    Publication date: April 3, 2003
    Applicant: Cytovia, Inc.
    Inventors: Sui Xiong Cai, Hong Zhang, Songchun Jiang, Richard Storer