Patents by Inventor Songqing WANG

Songqing WANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing lisinopril intermediate
    Patent number: 10633329
    Abstract: A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: April 28, 2020
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO., LTD., ZHEJIANG HUAHAI LICHENG PHARMACEUTICALS CO., LTD.
    Inventors: Songqing Wang, Peng Dong, Yang Zheng, Quanjun Li
  • METHOD FOR PREPARING LISINOPRIL INTERMEDIATE
    Publication number: 20190367444
    Abstract: A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.
    Type: Application
    Filed: November 17, 2017
    Publication date: December 5, 2019
    Inventors: Songqing WANG, Peng DONG, Yang ZHENG, Quanjun LI