Abstract: Provided herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation. The disclosure also provides pharmaceutically acceptable compositions comprising compounds and methods for the treatment of EGFR mutant-related cancers.

Abstract: A method, computer program product, and computing system for monitoring a portion of speech on an automated speech recognition system that includes a plurality of classifiers, thus defining a monitored portion of speech, wherein an operation is defined for each of the plurality of classifiers. A confidence score concerning the monitored portion of speech is associated with each of a plurality of classifiers, thus defining a plurality of confidence scores. If one of the plurality of confidence scores is an acceptable confidence score, the operation defined for the classifier associated with the acceptable confidence score is effectuated.

Abstract: A method, computer program product, and computing system for monitoring a portion of speech on an automated speech recognition system that includes a plurality of classifiers, thus defining a monitored portion of speech, wherein an operation is defined for each of the plurality of classifiers. A confidence score concerning the monitored portion of speech is associated with each of a plurality of classifiers, thus defining a plurality of confidence scores. If one of the plurality of confidence scores is an acceptable confidence score, the operation defined for the classifier associated with the acceptable confidence score is effectuated.