Patents by Inventor Sonia Gonzalez Blanco

Sonia Gonzalez Blanco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210252109
    Abstract: The present invention is related to the use of the growth hormone releasing peptide-6 (GHRP-6) for the manufacture of a late cardioprotective and cardiac restoration medicament. Said late cardioprotective and cardiac restoration medicament comprises GHRP-6 and a pharmaceutically acceptable excipient or vehicle. It also provides a method for the treatment of a disease that involves a low cardiac output, wherein a therapeutically effective amount of a late cardioprotective and cardiac restoration medicament comprising GHRP-6 is administered to a subject in need. Said medicament allows treating in a late manner, even days later, the myocardium that suffered episodes of stunning, hibernation, ischemia and its consequences thereof.
    Type: Application
    Filed: August 19, 2019
    Publication date: August 19, 2021
    Inventors: Jorge Amador BERLANGA ACOSTA, Gerardo Enrique GUILLÉN NIETO, Diana GARCIA DEL BARCO HERRERA, Francisco HERNÁNDEZ BERNAL, Sonia GONZALEZ BLANCO, Raimundo UBIETA GÓMEZ
  • Publication number: 20210196793
    Abstract: The invention discloses a pharmaceutical combination comprising epidermal growth factor (EGF) and the hexapeptide secretagogue GHRP6, useful for the restoration of brain damage, by stimulating mechanisms of differentiation and neuronal specialization in undifferentiated cells residing in the central nervous system or in neuronal cells. The invention also encompasses the use of the above mentioned biomolecules in the manufacture of a pharmaceutical combination for the restoration of brain damage. In addition, the invention provides a method of restoring brain damage in which a therapeutically effective amount of a pharmaceutical combination comprising EGF and GHRP6 is administered to a patient in need thereof. The efficacy of the pharmaceutical combination has a broad therapeutic window: it is independent of whether the pharmacological intervention occurs in the first or further hours after the brain damage, which broadens the therapeutic window.
    Type: Application
    Filed: August 16, 2019
    Publication date: July 1, 2021
    Inventors: Diana GARCIA DEL BARCO HERRERA, Gerardo Enrique GUILLÉN NIETO, Mariela VAZQUEZ CASTILLO, Francisco HERNÁNDEZ BERNAL, Tatiana ZALDIVAR VAILLANT, Pablo Arsenio DIAZ REYES, ldania Caridad BALADRON CASTRILLO, Vladimir Armando BESADA PÉREZ, Sonia GONZALEZ BLANCO, Jorge Amador BERLANGA ACOSTA, Héctor Manuel PÉREZ SAAD
  • Publication number: 20200297840
    Abstract: This invention reveals the pharmaceutical composition that includes the surface antigen (HBsAg) of the hepatitis B virus (HBV) and the antigen of the nucleocapsid (or core, HBcAg) of the same virus. The HBcAg of this composition contains messenger ribonucleic acid (mRNA) at a proportion of over 45% of the total amount of ribonucleic acid (RNA) in this antigen. Because of the changes in the constitution of the antigens forming it, the composition of the invention is useful for the prevention or treatment of chronic hepatitis B. It also covers the use of this pharmaceutical composition in the production of a drug for immuno-prophylaxis or immunotherapy against HBV infection, and its use to increase the immune response against an additional antigen that is co-administered with the mixture of these antigens.
    Type: Application
    Filed: March 14, 2017
    Publication date: September 24, 2020
    Inventors: Julio César AGUILAR RUBIDO, Yadira LOBAINA MATO, Enrique IGLESIAS PEREZ, Eduardo PENTÓN ARIAS, Gerardo Enrique GUILLÉN NIETO, Jorge Agustín AGUIAR SANTIAGO, Sonia GONZALEZ BLANCO, Jorge VALDES HERNANDEZ, Mariela VAZQUEZ CASTILLO
  • Publication number: 20180256112
    Abstract: The present invention is related to a stereotaxic frame for extremities that ensures that the extremity position is fixed and reproducible; keeping the same geometric conditions of the measurement or treatment devices regards the extremity, or part thereof, during the study or therapy. The frame comprises a positioning and fixing holder for the extremity and a measuring or treatment system, that includes a geometric locus where the measurement or treatment device is allocated, ensuring that the relative position of said device regards the region of the extremity under examination or treatment is reproducible.
    Type: Application
    Filed: September 22, 2016
    Publication date: September 13, 2018
    Inventors: Carlos Alberto CABAL MIRABAL, Evelio Rafael GONZÁLEZ DALMAU, Leonardo ORAMAS DIAZ, Luis Saturnino HERRERA MARTINEZ, Jorge Amador BERLANGA ACOSTA, José Ignacio FERNÁNDEZ MONTEQUÍN, Gerardo Enrique GUILLÉN NIETO, Luis Manuel FLORES DÍAZ, Orestes Lucio CABAÑAS RODRÍGUEZ, Sonia GONZALEZ BLANCO, Raimundo UBIETA GÓMEZ
  • Patent number: 9896482
    Abstract: The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: February 20, 2018
    Assignee: Centro de Ingenieria Genética y Biotechnologia
    Inventors: Glay Chinea Santiago, Vivian Huerta Galindo, Alejandro Miguel Martín Dunn, Hilda Elisa Garay Pérez, Osvaldo Reyes Acosta, Viviana Falcón Cama, Dianne Pupo Gómez, Alexis Yero Díaz, Gabriel Jesús Márquez Perera, Mónica Sarría Núñez, Osmany Guirola Cruz, Rocío Garateix Suárez, Karen Alvarez Pérez, Sonia González Blanco, Mariela Vázquez Castillo, Luis Javier González López
  • Patent number: 9676825
    Abstract: The invention relates to chimeric vaccine antigens against hepatitis C virus (HCV) comprising selected regions of different antigens of said virus, which are placed in a pre-determined order inside the polypeptide. In addition, said chimeric antigens can include artificially formed specific epitopes for auxiliary T helper lymphocytes. The chimeric antigens and the resulting vaccine compositions are suitable for use in medicine and the pharmaceutical industry, as well as being suitable for prophylactic and/or therapeutic use against HCV. The vaccine compositions of the invention generate a powerful, broad-spectrum immune response against different antigens of the virus, with a minimum number of components.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: June 13, 2017
    Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECHNOLOGIA
    Inventors: Santiago Dueñas Carrera, Daylen Aguilar Noriega, Yalena Amador Cañizares, Liz Alvarez-Lajonchere Ponce de León, Gillian Martínez Donato, Sonia Gonzalez Blanco
  • Publication number: 20170152290
    Abstract: The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.
    Type: Application
    Filed: February 26, 2015
    Publication date: June 1, 2017
    Inventors: Glay CHINEA SANTIAGO, Vivian HUERTA GALINDO, Alejandro Miguel MARTÍN DUNN, Hilda Elisa GARAY PÉREZ, Osvaldo REYES ACOSTA, Viviana FALCÓN CAMA, Dianne PUPO GÓMEZ, Alexis YERO DÍAZ, Gabriel Jesús MÁRQUEZ PERERA, Mónica SARRÍA NÚÑEZ, Osmany GUIROLA CRUZ, Rocío GARATEIX SUÁREZ, Karen ALVAREZ PÉREZ, Sonia GONZÁLEZ BLANCO, Mariela VÁZQUEZ CASTILLO, Luis Javier GONZÁLEZ LÓPEZ
  • Patent number: 9375459
    Abstract: The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: June 28, 2016
    Assignee: CENTRO DE INGENIERIA GENETICA BIOTECNOLGIA
    Inventors: María del Carmen Abrahantes Pérez, Glay Chinea Santiago, Eduardo Martínez Diaz, Hilda Elisa Garay Pérez, Osvaldo Reyes Acosta, Ernesto Lopez Mola, Cruz Matilde Lopez Abad, Sonia Gonzalez Blanco
  • Publication number: 20150307558
    Abstract: The invention relates to chimeric vaccine antigens against hepatitis C virus (HCV) comprising selected regions of different antigens of said virus, which are placed in a pre-determined order inside the polypeptide. In addition, said chimeric antigens can include artificially formed specific epitopes for auxiliary T helper lymphocytes. The chimeric antigens and the resulting vaccine compositions are suitable for use in medicine and the pharmaceutical industry, as well as being suitable for prophylactic and/or therapeutic use against HCV. The vaccine compositions of the invention generate a powerful, broad-spectrum immune response against different antigens of the virus, with a minimum number of components.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 29, 2015
    Inventors: Santiago Dueñas Carrera, Daylen Aguilar Noriega, Yalena Amador Cañizares, Liz Alvarez-Lajonchere Ponce de León, Gillian Martínez Donato, Sonia Gonzalez Blanco
  • Patent number: 9034826
    Abstract: The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: May 19, 2015
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Publication number: 20140112976
    Abstract: The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
    Type: Application
    Filed: March 21, 2012
    Publication date: April 24, 2014
    Applicant: CENTRO DE INGENIERIA GENETICA BIOTECNOLOGIA
    Inventors: María del Carmen Abrahantes Pérez, Glay Chinea Santiago, Eduardo Martínez Díaz, Hilda Elisa Garay Perez, Osvaldo Reyes Acosta, Ernesto Lopez Mola, Cruz Matilde Lopez Abad, Sonia Gonzalez Blanco
  • Publication number: 20140105990
    Abstract: The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as in ischemic neuritis.
    Type: Application
    Filed: December 26, 2013
    Publication date: April 17, 2014
    Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Patent number: 8642552
    Abstract: The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: February 4, 2014
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Publication number: 20120308615
    Abstract: The present invention is related with the field of the therapeutic immunization, specifically with the employment of a new formulation of antigens of the Hepatitis B Virus (HBV) for the cellular stimulation. The formulation is formed by the surface antigens (HBsAg) precipitated in suspension and the nucleocapsid (HBcAg) of the HBV. The formulation contains these antigens like suspended particles of sizes less than 500 nm and higher than 500 nm, in a mixture where the proportion among the particles of the mentioned sizes is among 50%-50% and 80%-20%, respectively. The selection of a range of sizes of particles allows that the levels of stimulation of several cellular types are maximized. Additionally, a cellular stimulation method is described with this formulation, and the later passive immunization of patients with chronic Hepatitis B, based on the maximum stimulation in vivo or in vitro using heterologous or autologous cells (dendritic cells, B cells and macrophages).
    Type: Application
    Filed: September 28, 2010
    Publication date: December 6, 2012
    Inventors: Julio César Aguilar Rubido, Yadira Lobaina Mato, Dunia Hernández Inguanzo, Heidy Trujillo Pérez, Freya de los Milagros Freyre Almeida, Verena Lucila Muzio González, Eduardo Pénton Arias, Sonia Gonzalez Blanco, Raimundo Ubieta Gómez, Gerardo Enrique Guillén Nieto, Luis Saturnino Herrera Martinez
  • Publication number: 20100300166
    Abstract: A composition to stimulate the development and growth of plants that comprises at least a Tsukamurella paurometabola strain, biofertilizing agent that optimize the assimilation of the organic matter by plants, favoring the intake of nitrogen and phosphorus by the plant.
    Type: Application
    Filed: April 29, 2008
    Publication date: December 2, 2010
    Inventors: Jesús Mena Campos, Eulogio Pimentel Vázquez, Marieta Marín Bruzos, Armando Tomás Hernández García, Ileana Sánchez Ortiz, Yamilka Ramírez Núñez, Sonia González Blanco, Marianela García Siverio, Carlos Guillermo Borroto Nordelo
  • Publication number: 20100172931
    Abstract: The present invention is related to field of medicine, particularly to the development of pharmaceutical composition containing the NMB1796 protein. The composition described in this invention are able to confer protection against different diseases caused or not by pathogenic agents. The NMB1796 protein was identified as a Neisseria meningitidis outer membrane vesicle (OMV) component, and it was obtained through recombinant DNA technology being its immunogenicity and protective activity evaluated in animal models. Due to the high level of conservation that the NMB1796 coding gene has shown, pharmaceutical compositions containing this protein have a high value as inducers of a cross-reactive immune response. The composition presented in this invention is applicable to the field of human medicine.
    Type: Application
    Filed: June 16, 2008
    Publication date: July 8, 2010
    Inventors: Rolando Pajon Feyt, Olivia Niebla Perez, Gretel Sardinas Garcia, Sonia Gonzalez Blanco, Darien Garcia Diaz, Evelin Caballero Menendez, Karem Cobas Acosta
  • Publication number: 20100136062
    Abstract: The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
    Type: Application
    Filed: October 1, 2007
    Publication date: June 3, 2010
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Publication number: 20100129387
    Abstract: The present invention is related to field of medicine, particularly to the development of pharmaceutical formulation containing NMB0606 protein. Formulation described in this invention is able to confer protection against different diseases caused or not by pathogenic agents. NMB0606 protein was identified as a Neisseria meningitidis outer membrane vesicle (OMV) component, and it was obtained through recombinant DNA technology being its immunogenicity and protective activity evaluated in animal models. Due to the high level of conservation the NMB0606 coding gene has shown, pharmaceutical composition containing this protein has a high value as inducers of a cross-reactive immune response. Formulation presented in this invention is applicable to the field of human medicine.
    Type: Application
    Filed: March 29, 2007
    Publication date: May 27, 2010
    Inventors: Rolando Pajón Feyt, Karem Cobas Acosta, Yasser Perera Negrin, Gretel Sardiñas Garcia, Darién Garcia Diaz, Sonia Gonzalez Blanco
  • Publication number: 20090297547
    Abstract: The present invention is related to field of medicine, particularly to the development of pharmaceutical formulation containing NMB0938 protein. Formulation described in this invention is able to confer protection against different diseases caused or not by pathogenic agents. NMB0938 protein was identified as a Neisseria meningitidis outer membrane vesicle (OMV) component, and it was obtained through recombinant DNA technology being its immunogenicity and protective activity evaluated in animal models. Due to the high level of conservation the NMB0938 coding gene has shown, pharmaceutical compositions containing this protein have a high value as inducers of a cross-reactive immune response. Formulation presented in this invention is applicable to the field of human medicine.
    Type: Application
    Filed: March 29, 2007
    Publication date: December 3, 2009
    Inventors: Rolando Pajon Feyt, Gretel Sardinas Garcia, Darien Garcia Diaz, Sonia Gonzalez Blanco
  • Publication number: 20090208521
    Abstract: The present invention is related to field of medicine, particularly to the development of pharmaceutical formulations containing NMA0939 protein. Formulations described in this invention are able to confer protection against different diseases caused or not by pathogenic agents. NMA0939 protein was identified as a Neisseria meningitidis outer membrane vesicle component, and it was obtained through recombinant DNA technology being its immunogenicity and protective activity evaluated in animal models. Due to the high level of conservation the NMA0939 coding gene has shown, pharmaceutical compositions containing this protein have a high value as inducers of a cross-reactive immune response. Formulations presented in this invention are applicable to the field of human medicine.
    Type: Application
    Filed: December 28, 2006
    Publication date: August 20, 2009
    Inventors: Rolando Pajon Feyt, Gretel Sardinas Garcia, Agustin Lage Castellanos, Daniel Yero Corona, Darien Garcia Diaz, Sonia Gonzalez Blanco