Patents by Inventor Sonia Grego

Sonia Grego has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210251558
    Abstract: A computer implemented method is disclosed for detecting a mild traumatic brain injury (mTBI) on a subject having recently suffered a head injury. The method includes (1) receiving first electrocardiogram (ECG) data from the subject during a first transition from a first position to a second position; and (2) determining a probability value of mTBI within the subject based at least partially on the first ECG data during the first transition. The first position may be a prone position or a supine position and the second position may be a standing position.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 19, 2021
    Inventors: Kristin Hedgepath Gilchrist, Sonia Grego, Gregory Frederick Lewis, Meghan Sarah Hegarty-Craver
  • Publication number: 20140335496
    Abstract: A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.
    Type: Application
    Filed: December 4, 2012
    Publication date: November 13, 2014
    Applicants: Research Triangle Institute, The University of North Carolina at Chapel Hill
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, Scott H. Randell
  • Publication number: 20140308688
    Abstract: A multiple flow-based microfluidic cell culture system that emulates mammalian physiology is provided. Tissue-mimicking cell cultures are connected by flow within a physiologically meaningful arrangement so that the pharmacokinetics of various agents to be tested in the system emulate in vivo conditions. The system includes at least two organ tissue modules, each organ tissue module including a first chamber containing an organ tissue cell, the first chamber including an inlet and an outlet for flow of an organ tissue cell-specific culture medium; a second chamber including an inlet and an outlet for flow of a blood material; and a semi-permeable membrane separating the first and second chambers. The flow of blood material through each organ tissue module is interconnected and the flow of tissue-cell specific culture medium is directed to a single organ tissue module.
    Type: Application
    Filed: December 7, 2012
    Publication date: October 16, 2014
    Inventors: Sonia Grego, Brian Rhys Stoner, Kristin Hedgepath Gilchrist, Timothy Raymond Fennell, Ann Pitruzzello
  • Patent number: 8700134
    Abstract: The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: April 15, 2014
    Assignee: Research Triangle Institute
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, David Edward Dausch, Michael Kasper Lamvik
  • Publication number: 20140080729
    Abstract: An optical sensing device and associated apparatus are configured for multiplexed detection of specific analytes in fluid samples. The device has a wavelength-tunable grating-coupler configuration in which a grating is disposed on a surface of a waveguide. Different regions of the grating may be functionalized with different receptors, and may form binding-specific sensors and reference sensors. The receptors are exposed to a fluid sample utilizing a fluidic structure mounted to the device. The device utilizes evanescent waves to sense analytes bound to the waveguide surface. The evanescent wave is sensitive to changes in refractive index at (or near) the waveguide surface. Changes in refractive index occur proportionally to the mass of the bound analyte. The apparatus utilizes a tunable light source to implement swept wavelength interrogation while the input beam is held at a fixed coupling angle relative to the waveguide and grating.
    Type: Application
    Filed: March 16, 2012
    Publication date: March 20, 2014
    Applicant: Research Triangle Institute, International
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist
  • Patent number: 8617704
    Abstract: A coated medical implant, such as a coated dental component, is provided, the coated medical implant including a substrate surface formed of a material comprising available hydroxyl groups and a silicon oxide coating layer chemisorbed on the substrate surface. A method for the preparation of such coated implants is also provided, the method involving application of the silicon oxide coating layer to the substrate surface by chemical vapor deposition. A dental structure is also provided, which includes a first dental component having a substrate surface formed of a material comprising available hydroxyl groups; a silicon oxide coating layer chemisorbed on the substrate surface; a silane coupling agent overlying and covalently attached to the silicon oxide layer; a dental cement overlying and coupled to the silane coupling agent; and a second dental component having a surface bonded to the dental cement.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: December 31, 2013
    Assignees: Research Triangle Institute, Nova Southeastern University
    Inventors: Jeffrey Robert Piascik, Jeffrey Yates Thompson, Sonia Grego, Brian R. Stoner
  • Publication number: 20120080612
    Abstract: The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other
    Type: Application
    Filed: February 26, 2010
    Publication date: April 5, 2012
    Applicant: Research Triangle Institute
    Inventors: Sonia Grego, Kristin Hedgepath Gilchrist, David Edward Dausch, Michael Kasper Lamvik
  • Publication number: 20120034572
    Abstract: A coated medical implant, such as a coated dental component, is provided, the coated medical implant including a substrate surface formed of a material comprising available hydroxyl groups and a silicon oxide coating layer chemisorbed on the substrate surface. A method for the preparation of such coated implants is also provided, the method involving application of the silicon oxide coating layer to the substrate surface by chemical vapor deposition. A dental structure is also provided, which includes a first dental component having a substrate surface formed of a material comprising available hydroxyl groups; a silicon oxide coating layer chemisorbed on the substrate surface; a silane coupling agent overlying and covalently attached to the silicon oxide layer; a dental cement overlying and coupled to the silane coupling agent; and a second dental component having a surface bonded to the dental cement.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Inventors: Jeffrey Robert Piascik, Jeffrey Yates Thompson, Sonia Grego, Brian R. Stoner
  • Patent number: 6924921
    Abstract: A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry. Charged polymers such as polyelectrolyte coatings can be used to create the bonds.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: August 2, 2005
    Assignee: MCNC Research & Development Institute
    Inventors: John South Lewis, lll, Scott Halden Goodwin-Johansson, Brian Rhys Stoner, Sonia Grego, David Edward Dausch
  • Publication number: 20040134414
    Abstract: A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry. Charged polymers such as polyelectrolyte coatings can be used to create the bonds.
    Type: Application
    Filed: December 22, 2003
    Publication date: July 15, 2004
    Inventors: John South Lewis, Scott Halden Goodwin-Johansson, Brian Rhys Stoner, Sonia Grego, David Edward Dausch
  • Patent number: 6752868
    Abstract: A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A templated substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: June 22, 2004
    Assignee: MCNC Research & Development Institute
    Inventors: John South Lewis, III, Scott Halden Goodwin-Johansson, Brian Rhys Stoner, Sonia Grego, David Edward Dausch
  • Publication number: 20040020423
    Abstract: A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A templated substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry.
    Type: Application
    Filed: July 31, 2002
    Publication date: February 5, 2004
    Inventors: John South Lewis, Scott Halden Goodwin-Johansson, Brian Rhys Stoner, Sonia Grego, David Edward Dausch
  • Publication number: 20030223111
    Abstract: A sample analysis device is provided, the device comprising a frame adapted to accept at least one analysis apparatus, with each analysis apparatus having an analysis distance associated therewith. A eucentric goniometer is operably engaged with the frame and is adapted to eucentrically support a sample at a eucentric point within a reference system defined by the eucentric goniometer. The reference system of the eucentric goniometer is independent of the analysis distance. An axial adjustment device is operably engaged with at least one of the frame and the eucentric goniometer and is configured to coincidentally position the eucentric point and the analysis distance for the respective analysis apparatus. An associated device and method are also provided.
    Type: Application
    Filed: May 31, 2002
    Publication date: December 4, 2003
    Applicant: MCNC
    Inventors: Michael K. Lamvik, Sonia Grego, Gary E. McGuire