Abstract: Disclosed herein an anti-pT217 Tau antibody or a pT217 Tau-binding fragment thereof.

Abstract: A method and a system for interrogating an optical fiber includes a probe signal that has a first frequency comb at a first repetition rate (?f) injected into the optical fiber. A backscattering signal that includes the probe signal convolved with an impulse response of the optical fiber in reflection which is sensitive to at least one parameter being measured from the optical fiber is gathered. The backscattering signal is beaten with a local oscillator signal to generate a beating signal, the local oscillator signal including a second frequency comb at a second repetition rate that is offset from the first repetition rate (?f+?f) and being mutually coherent with the first frequency comb. The resulting beating signal is analysed to thereby determine the at least one parameter being measured from the optical fiber.

Abstract: A method and a system for interrogating an optical fiber includes a probe signal that has a first frequency comb at a first repetition rate (?f) injected into the optical fiber. A backscattering signal that includes the probe signal convolved with an impulse response of the optical fiber in reflection which is sensitive to at least one parameter being measured from the optical fiber is gathered. The backscattering signal is beaten with a local oscillator signal to generate a beating signal, the local oscillator signal including a second frequency comb at a second repetition rate that is offset from the first repetition rate (?f+?f) and being mutually coherent with the first frequency comb. The resulting beating signal is analysed to thereby determine the at least one parameter being measured from the optical fiber.

Abstract: System and method of distributed sensing based on Brillouin stimulated scattering on optical fiber (3), consisting of separating the two signals of which the probe signal is composed and obtaining the difference between the stimulated amplification band (8) and the attenuation band (9), or vice-versa. In this way a signal is obtained with greater amplitude than in the case of detection being performed with a single band. Thus the signal-to-noise ratio is improved in the sensor signal, dynamic range and the range is increased and the uncertainty of the measurement is decreased. It also eliminates the common noise present in the two bands of the probe signal and, in the case of using a balanced detector in detection, it improves the saturation characteristics of the detector, being able to achieve much larger signal amplitudes than in the conventional case.

Abstract: System and method of distributed sensing based on Brillouin stimulated scattering on optical fiber (3), consisting of separating the two signals of which the probe signal is composed and obtaining the difference between the stimulated amplification band (8) and the attenuation band (9), or vice-versa. In this way a signal is obtained with greater amplitude than in the case of detection being performed with a single band. Thus the signal-to-noise ratio is improved in the sensor signal, dynamic range and the range is increased and the uncertainty of the measurement is decreased. It also eliminates the common noise present in the two bands of the probe signal and, in the case of using a balanced detector in detection, it improves the saturation characteristics of the detector, being able to achieve much larger signal amplitudes than in the conventional case.

Abstract: The invention described herein is a device for dripping a tissue sealant and/or adhesive that comprises a) first and second barrels or syringes that contain first and second biocomponents that are disposed between proximal and distal ends; b) a plunger in each barrel and c) a drip tip comprising i) a support having distal and proximal ends and at least two fluid passageways from the distal to the proximal end that are in fluid communication with one of the barrels of the dispensing device on the proximal end; and ii) an endcap that fits over the support having at least two flexible hinges. The present invention is also directed to an assembly for mixing and drip dispensing two reactive biologic components as tissue sealant and/or hemostatic agent and to methods for delivering biologic components to achieve hemostasis and/or tissue sealant by drip dispensing from the device described above.

Abstract: The present disclosure is based on distributed amplification based on the Raman Effect, consisting of one or more pump lasers (5) at various wavelengths combined with a variable number of fiber optic reflectors (6). These elements induce in the fiber optic sensor (4) or measurement object the necessary conditions for the propagation of the sensor or measurement equipment signals in virtual transparency mode, improving the signal-to-noise ratio in the sensor and measurement equipment signal, improving the dynamic range and increasing the range of the sensor or measurement equipment by up to 250 km.

Abstract: The invention described herein is a device for dripping a tissue sealant and/or adhesive that comprises a) first and second barrels or syringes that contain first and second biocomponents that are disposed between proximal and distal ends; b) a plunger in each barrel and c) a drip tip comprising i) a support having distal and proximal ends and at least two fluid passageways from the distal to the proximal end that are in fluid communication with one of the barrels of the dispensing device on the proximal end; and ii) an endcap that fits over the support having at least two flexible hinges. The present invention is also directed to an assembly for mixing and drip dispensing two reactive biologic components as tissue sealant and/or hemostatic agent and to methods for delivering biologic components to achieve hemostasis and/or tissue sealant by drip dispensing from the device described above.

Abstract: The present disclosure is based on distributed amplification based on the Raman Effect, consisting of one or more pump lasers (5) at various wavelengths combined with a variable number of fibre optic reflectors (6). These elements induce in the fibre optic sensor (4) or measurement object the necessary conditions for the propagation of the sensor or measurement equipment signals in virtual transparency mode, improving the signal-to-noise ratio in the sensor and measurement equipment signal, improving the dynamic range and increasing the range of the sensor or measurement equipment by up to 250 km.

Abstract: The present inventions includes a plurality of packed particles that contain interstitial pores, where the interstitial pores have a pore volume and a median pore diameter effective to provide improved absorption of physiological fluids or an aqueous media when placed in contact therewith, compared to a plurality of unpacked particles of the same material, where the particles are made of a biocompatible material and hemostatic agents and have an average diameter suitable for use in providing hemostasis to a site of a body of a mammal requiring hemostasis, hemostatic compositions containing such plurality of packed particles, methods of making such particles and compositions and medical devices suitable for delivering and containing the hemostatic plurality of particles and/or composition to a site of a body.

Abstract: According to embodiments of the present invention, there is provided an apparatus for controlling melt flow through a portion of the melt distribution network. A flow control device is provided. The flow control device comprises a body defining: a mixer configured to be positioned in a conduit for providing a path of flow for melt such that the mixer traverses substantially the whole cross-section of the path of flow; a temperature control portion associated with the mixer for actively controlling temperature of the mixer.

Abstract: The present invention is directed towards a hemostat comprising an absorbable foam, an absorbable woven or knitted fabric, thrombin and/or fibrinogen.

Abstract: The present inventions includes a plurality of packed particles that contain interstitial pores, where the interstitial pores have a pore volume and a median pore diameter effective to provide improved absorption of physiological fluids or an aqueous media when placed in contact therewith, compared to a plurality of unpacked particles of the same material, where the particles are made of a biocompatible material and have an average diameter suitable for use in providing hemostasis to a site of a body of a mammal requiring hemostasis, hemostatic compositions containing such plurality of packed particles, methods of making such particles and compositions and medical devices suitable for delivering and containing the hemostatic plurality of particles and/or composition to a site of a body.

Abstract: The present inventions includes a plurality of packed particles that contain interstitial pores, where the interstitial pores have a pore volume and a median pore diameter effective to provide improved absorption of physiological fluids or an aqueous media when placed in contact therewith, compared to a plurality of unpacked particles of the same material, where the particles are made of a biocompatible material and hemostatic agents and have an average diameter suitable for use in providing hemostasis to a site of a body of a mammal requiring hemostasis, hemostatic compositions containing such plurality of packed particles, methods of making such particles and compositions and medical devices suitable for delivering and containing the hemostatic plurality of particles and/or composition to a site of a body.