Patents by Inventor Sonia Timberlake

Sonia Timberlake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Delivering a Bacterial Metabolite to a Subject
    Publication number: 20240131082
    Abstract: The present disclosure relates to compositions comprising preparations of uncultured fecal bacteria, methods of manufacturing the compositions, and methods of using the compositions to treat a disorder related to a gut dysbiosis.
    Type: Application
    Filed: October 18, 2020
    Publication date: April 25, 2024
    Applicant: Finch Therapeutics Holdings LLC
    Inventors: Mark SMITH, Sonia TIMBERLAKE, Zain KASSAM, Anh-Thu Elaine VO, John HENSKE, Ylaine GERARDIN, Rotem Gura SADOVSKY
  • HPV-specific binding molecules
    Patent number: 11952408
    Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 9, 2024
    Assignees: Juno Therapeutics, Inc., Editas Medicine, Inc.
    Inventors: Cameron Brandt, Brian Belmont, Christopher Borges, Stephen Michael Burleigh, Alexandra Croft, Stephen Jacob Goldfless, David Jeffrey Huss, Yue Jiang, Timothy G. Johnstone, David Koppstein, Hieu Nguyen, Christopher Heath Nye, Haley Peper, Blythe D. Sather, Sonia Timberlake, Dean Y. Toy, Queenie Vong, Gordon Grant Welstead, James Sissons
  • HIGH-THROUGHPUT NUCLEOTIDE LIBRARY SEQUENCING
    Publication number: 20240076732
    Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, alpha and beta chain T-cell receptor sequences, or gamma and delta chain T-cell receptor sequences, for antibody and T-cell receptor discovery, disease and immune diagnostics, and low error sequencing.
    Type: Application
    Filed: November 10, 2022
    Publication date: March 7, 2024
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Christopher Ryan Clouser, Stephen Jacob Goldfless, Sonia Timberlake
  • COMPOSITIONS COMPRISING NON-VIABLE FECAL MICROBIOTA AND METHODS OF USE THEREOF
    Publication number: 20230201265
    Abstract: The present disclosure relates to compositions comprising a non-viable fecal bacterial preparation for treating various gastrointestinal-related conditions and disorders. The present disclosure also relates to stool-based compositions comprising adjuvants to facilitate the efficacy of immunomodulators such as vaccines and immunotherapies.
    Type: Application
    Filed: March 31, 2021
    Publication date: June 29, 2023
    Applicant: Finch Therapeutics Holdings LLC
    Inventors: Mark SMITH, Christopher WEIDENMAIER, Sonia TIMBERLAKE
  • Broadly neutralizing anti-HIV-1 antibodies that bind to an N-glycan epitope on the envelope
    Patent number: 11572403
    Abstract: This invention relates to novel anti-HIV antibodies that can be used in the treatment and detection of human immunodeficiency virus (HIV). These antibodies exhibit a high degree of sensitivity and can provide a broad range of specificity.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: February 7, 2023
    Assignee: ABVITRO LLC
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Stephen J. Goldfless, Sonia Timberlake
  • METHODS AND PRODUCTS FOR TREATMENT OF GASTROINTESTINAL DISORDERS
    Publication number: 20220257670
    Abstract: Described herein are compositions and methods for the delivery of microbial therapeutics useful for the treatment of disorders related to intestinal dysbiosis.
    Type: Application
    Filed: July 17, 2020
    Publication date: August 18, 2022
    Inventors: Mark SMITH, Anh-Thu Elaine VO, Rotem SADOVSKY, John HENSKE, Ylaine GERARDIN, Sonia TIMBERLAKE
  • METHODS AND PRODUCTS FOR TREATMENT OF GASTROINTESTINAL DISORDERS
    Publication number: 20220257673
    Abstract: Described herein are compositions and methods for the delivery of microbial therapeutics useful for the treatment of disorders related to intestinal dysbiosis.
    Type: Application
    Filed: July 17, 2020
    Publication date: August 18, 2022
    Inventors: Mark SMITH, Anh-Thu Elaine VO, Rotem SADOVSKY, John HENSKE, Ylaine GERARDIN, Sonia TIMBERLAKE, Cosmos GIALLOURAKIS, Ewan TAYLOR
  • Broadly neutralizing anti-HIV-1 antibodies that bind to an N-glycan epitope on the envelope
    Patent number: 11142565
    Abstract: This invention relates to novel anti-HIV antibodies that can be used in the treatment and detection of human immunodeficiency virus (HIV). These antibodies exhibit a high degree of sensitivity and can provide a broad range of specificity.
    Type: Grant
    Filed: September 24, 2016
    Date of Patent: October 12, 2021
    Assignee: AbVitro LLC
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Stephen J. Goldfless, Sonia Timberlake
  • HPV-SPECIFIC BINDING MOLECULES
    Publication number: 20210284709
    Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.
    Type: Application
    Filed: September 28, 2018
    Publication date: September 16, 2021
    Applicants: Juno Therapeutics, Inc., Editas Medicine, Inc.
    Inventors: Cameron BRANDT, Brian BELMONT, Christopher BORGES, Stephen Michael BURLEIGH, Alexandra CROFT, Stephen Jacob GOLDFLESS, David Jeffrey HUSS, Yue JIANG, Timothy G. JOHNSTONE, David KOPPSTEIN, Hieu NGUYEN, Christopher Heath NYE, Haley PEPER, Blythe D. SATHER, Sonia TIMBERLAKE, Dean Y. TOY, Queenie VONG, Gordon Grant WELSTEAD, James SISSONS
  • Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
    Patent number: 10982258
    Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, for antibody discovery, disease and immune diagnostics, and low error sequencing.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: April 20, 2021
    Assignee: AbVitro LLC
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Christopher Ryan Clouser, Stephen Jacob Goldfless, Sonia Timberlake
  • HIV ANTIBODY COMPOSITIONS AND METHODS OF USE
    Publication number: 20210101963
    Abstract: This invention relates to novel anti-HIV antibodies that can be used in the treatment and detection of human immunodeficiency virus (HIV). These antibodies exhibit a high degree of sensitivity and can provide a broad range of specificity.
    Type: Application
    Filed: September 2, 2020
    Publication date: April 8, 2021
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Stephen J. Goldfless, Sonia Timberlake
  • Methods of Sequencing, Determining, Pairing, and Validating Therapeutic Agents and Disease Specific Antigens
    Publication number: 20210079454
    Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, for antibody discovery, disease and immune diagnostics, and low error sequencing.
    Type: Application
    Filed: August 31, 2020
    Publication date: March 18, 2021
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Christopher Ryan Clouser, Stephen Jacob Goldfless, Sonia Timberlake
  • TREATMENT OF LIVER DISEASE BY MODULATION OF THE MICROBIOME
    Publication number: 20200360450
    Abstract: The present invention relates to, in part, compositions and methods for delivery of mixtures of bacterial strains for treating and/or preventing Primary Sclerosing Cholangitis (PSC).
    Type: Application
    Filed: August 7, 2018
    Publication date: November 19, 2020
    Inventors: Sonia TIMBERLAKE, Ylaine GERARDIN
  • METHODS AND COMPOSITIONS FOR TREATING DISORDERS RELATED TO A GUT DYSBIOSIS
    Publication number: 20200281991
    Abstract: This application provides methods for determining or monitoring the pharmacokinetics (PK) and stable engraftment of live microbial therapeutics, in a subject, through a machine learning model. Disclosed herein is the monitoring and treating of a disorder related to a gut dysbiosis or inflammatory bowel disease in a subject.
    Type: Application
    Filed: March 9, 2020
    Publication date: September 10, 2020
    Applicant: Crestovo Holdings LLC
    Inventors: Ylaine GERARDIN, Sonia TIMBERLAKE, Michael SILVERSTEIN
  • HIGH-THROUGHPUT NUCLEOTIDE LIBRARY SEQUENCING
    Publication number: 20200239955
    Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, alpha and beta chain T-cell receptor sequences, or gamma and delta chain T-cell receptor sequences, for antibody and T-cell receptor discovery, disease and immune diagnostics, and low error sequencing.
    Type: Application
    Filed: February 3, 2020
    Publication date: July 30, 2020
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Christopher Ryan Clouser, Stephen Jacob Goldfless, Sonia Timberlake
  • COMPOSITIONS AND METHODS FOR TREATING DISORDERS RELATED TO A GUT DYSBIOSIS
    Publication number: 20200164000
    Abstract: This application provides a microbiome disruption index (MDI) for determining or monitoring the taxonomic structure of an intestinal or fecal microbiota of a subject. Disclosed herein is the use of an MDI in the diagnosis, treatment or prognosis of disorders, diseases, conditions or indications caused by, associated with, or related to a gut dysbiosis. Further disclosed is the use of MDI to assess the efficacy of a microbiome-based therapy.
    Type: Application
    Filed: October 29, 2019
    Publication date: May 28, 2020
    Applicant: CRESTOVO HOLDINGS LLC
    Inventors: Marina SANTIAGO, Sonia TIMBERLAKE
  • High-throughput nucleotide library sequencing
    Patent number: 10590483
    Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, alpha and beta chain T-cell receptor sequences, or gamma and delta chain T-cell receptor sequences, for antibody and T-cell receptor discovery, disease and immune diagnostics, and low error sequencing.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: March 17, 2020
    Assignee: AbVitro LLC
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Christopher Ryan Clouser, Stephen Jacob Goldfless, Sonia Timberlake
  • HPV-SPECIFIC BINDING MOLECULES
    Publication number: 20190225692
    Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.
    Type: Application
    Filed: October 3, 2017
    Publication date: July 25, 2019
    Applicant: Juno Therapeutics, Inc.
    Inventors: James SISSONS, Cameron BRANDT, Alexandra CROFT, Allen EBENS, Haley PEPER, Dean Y. TOY, Brian BELMONT, Stephen GOLDFLESS, Yue JIANG, Timothy JOHNSTONE, David KOPPSTEIN, Hieu NGUYEN, Blythe SATHER, Sonia TIMBERLAKE
  • HIV ANTIBODY COMPOSITIONS AND METHODS OF USE
    Publication number: 20190048067
    Abstract: This invention relates to novel anti-HIV antibodies that can be used in the treatment and detection of human immunodeficiency virus (HIV). These antibodies exhibit a high degree of sensitivity and can provide a broad range of specificity.
    Type: Application
    Filed: September 24, 2016
    Publication date: February 14, 2019
    Inventors: Francois Vigneault, Adrian Wrangham Briggs, Stephen J. Goldfless, Sonia Timberlake
  • Methods of Sequencing, Determining, Pairing, and Validating Therapeutic Agents and Disease Specific Antigens
    Publication number: 20190024145
    Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, for antibody discovery, disease and immune diagnostics, and low error sequencing.
    Type: Application
    Filed: April 27, 2016
    Publication date: January 24, 2019
    Applicant: AbVitro LLC
    Inventors: Francois Vigneault, V, Adrian Wrangham BRIGGS, Christopher Ryan CLOUSER, Stephen Jacob GOLDFLESS, Sonia TIMBERLAKE