Abstract: A baby car carrier dimensioned to hold a small child safely in a motor vehicle. The base of the device sets atop a car seat and is secured by means of a seatbelt. A frame is rotatably affixed to the top of the base. The top of the frame is concave and slidably supports the convex bottom of a cradle assembly. The cradle assembly can recline relative to the frame by motorized means. A plurality of padded nesting inserts are provided on top of the cradle assembly allowing for growing children by successive removal of the nesting inserts. Variations further include cup holders, trays, a retractable shade, a headrest, an inflatable pillow, vibration, heat, and an arm to dangle a toy.

Abstract: Exemplary embodiments disclosed herein demonstrate that the Snail1 gene contributes to FGFR3 receptor signal transduction, which contributes to chondrodysplasias (achondroplasia (ACH), thanatophoric dysplasia (TD) and hypochondroplasia (HCH)). The exemplary embodiments identify Snail1 as a therapeutic and diagnostic target for chondrodysplasia, as well as the use of inhibitors thereof as drugs for the treatment of these diseases.