Patents by Inventor Sonja Leyrer

Sonja Leyrer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant poxvirus expressing homologous genes inserted
    Patent number: 9109233
    Abstract: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: August 18, 2015
    Assignee: BAVARIAN NORDIC A/S
    Inventors: Paul Howley, Sonja Leyrer
  • Flavivirus NS1 subunit vaccine
    Patent number: 8815501
    Abstract: The present invention relates to NS1 proteins or parts thereof of Flaviviruses, in particular of Dengue viruses useful for vaccination against said Flavivirus and against one or more other Flaviviruses. The invention further concerns the NS1 protein or parts thereof of one Dengue virus serotype, in particular serotype 2, useful for vaccination against Dengue viruses from all serotypes. The invention further concerns DNA comprising an expression cassette coding for a Flavivirus NS1 or parts thereof, vectors comprising said DNA and vaccines containing or expressing a Flavivirus NS1.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: August 26, 2014
    Assignees: Bavarian Nordic A/S, Venture Technologies SDN BHD
    Inventors: Paul Howley, Sonja Leyrer, Mary Jane Cardosa, Magdeline Sia Henry Sum
  • Single recombination system and methods of use
    Patent number: 8741653
    Abstract: The present invention is directed to a modified poxvirus vector that allows for the generation of recombinant poxviruses by a single recombination event. A modified poxvirus vector comprising at least one reporter gene located between two flanking sequences for homologous recombination is disclosed. Furthermore, a host cell comprising said vector and a method for the generation of recombinant poxviruses using said vector are provided.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: June 3, 2014
    Assignee: Emergent Product Development GmbH
    Inventors: Sonja Leyrer, Katja Fischer
  • Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (MVA)
    Patent number: 8741308
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: June 3, 2014
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer
  • INTERGENIC REGIONS AS INSERTION SITES IN THE GENOME OF MODIFIED VACCINIA VIRUS ANKARA (MVA)
    Publication number: 20130243813
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Application
    Filed: May 2, 2013
    Publication date: September 19, 2013
    Applicant: BAVARIAN NORDIC A/S
    Inventors: PAUL HOWLEY, SONJA LEYRER
  • Fusion proteins of HIV regulatory/accessory proteins
    Patent number: 8435535
    Abstract: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: May 7, 2013
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer, Eva Felder
  • Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (MVA)
    Patent number: 8435543
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 7, 2013
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer
  • Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (MVA)
    Patent number: 8414900
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: April 9, 2013
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer
  • Fusion proteins of HIV regulatory/accessory proteins
    Patent number: 8389275
    Abstract: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: March 5, 2013
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer, Eva Felder
  • Method for generating a stable recombinant modified vaccinia virus ankara (MVA) comprising human immunodeficiency virus (HIV) genes inserted into one or more intergenic regions (IGRs)
    Patent number: 8323661
    Abstract: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: December 4, 2012
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer, Paul Chaplin, Eva Felder
  • Recombinant modified vaccinia ankara (MVA) virus containing heterologous DNA inserts encoding human immunodeficiency virus (HIV) antigens inserted into one or more intergenic regions (IGRs)
    Patent number: 8309098
    Abstract: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 13, 2012
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer, Paul Chaplin, Eva Felder
  • Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (MVA)
    Patent number: 8309326
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: November 13, 2012
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer
  • Intergenic regions as insertion sites in the genome of modified vaccinia virus Ankara (MVA)
    Patent number: 8288125
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: October 16, 2012
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer
  • RECOMBINANT POXVIRUS EXPRESSING HOMOLOGOUS GENES INSERTED INTO THE POXVIRAL GENOME
    Publication number: 20120178157
    Abstract: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided.
    Type: Application
    Filed: February 13, 2012
    Publication date: July 12, 2012
    Inventors: Paul HOWLEY, Sonja Leyrer
  • Method for the production of human immunodeficiency virus (HIV) proteins utilizing modified vaccinia virus ankara (MVA) recombinants comprising HIV genes inserted into one or more intergenic regions (IGRs)
    Patent number: 8197822
    Abstract: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: June 12, 2012
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer, Paul Chaplin, Eva Felder
  • Method for introducing human immunodeficiency virus nucleotide sequences into a cell utilizing modified vaccinia virus Ankara (MVA) recombinants comprising HIV genes inserted into one or more intergenic regions (IGRs)
    Patent number: 8198088
    Abstract: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: June 12, 2012
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer, Paul Chaplin, Eva Felder
  • FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS
    Publication number: 20120142096
    Abstract: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.
    Type: Application
    Filed: February 14, 2012
    Publication date: June 7, 2012
    Inventors: Paul HOWLEY, Sonja LEYRER, Eva FELDER
  • FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS
    Publication number: 20120142097
    Abstract: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.
    Type: Application
    Filed: February 14, 2012
    Publication date: June 7, 2012
    Inventors: Paul HOWLEY, Sonja Leyrer, Eva Felder
  • Recombinant poxvirus expressing homologous genes inserted
    Publication number: 20120135501
    Abstract: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided.
    Type: Application
    Filed: November 15, 2007
    Publication date: May 31, 2012
    Inventors: Paul Howley, Sonja Leyrer
  • INTERGENIC REGIONS AS INSERTION SITES IN THE GENOME OF MODIFIED VACCINIA VIRUS ANKARA (MVA)
    Publication number: 20120082696
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into said new insertion site as medicine or vaccine.
    Type: Application
    Filed: September 16, 2011
    Publication date: April 5, 2012
    Inventors: Paul HOWLEY, Sonja Leyrer