Patents by Inventor Sonja Mackey

Sonja Mackey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes to prepare eplerenone
    Publication number: 20070129332
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Application
    Filed: December 21, 2006
    Publication date: June 7, 2007
    Inventors: Bruce Pearlman, Amphlett Padilla, Jeffrey Havens, Sonja Mackey, Haifeng Wu
  • 7alpha-biscarbonyl-substituted steroid compounds
    Publication number: 20070123704
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 31, 2007
    Inventors: Bruce Pearlman, Amphlett Padilla, Jeffrey Havens, Sonja Mackey, Haifeng Wu
  • Process to Prepare Eplerenone
    Publication number: 20070117780
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 24, 2007
    Inventors: Bruce Pearlman, Amphlett Padilla, Jeffrey Havens, Sonja MacKey, Haifeng Wu
  • 7a-Furyl or thienyl-substituted steroid compounds
    Publication number: 20070106072
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 10, 2007
    Inventors: Bruce Pearlman, Amphlett Padilla, Jeffrey Havens, Sonja Mackey, Haifeng Wu
  • Process to Prepare Eplerenone
    Publication number: 20070100140
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Application
    Filed: December 21, 2006
    Publication date: May 3, 2007
    Inventors: Bruce Pearlman, Amphlett Padilla, Jeffrey Havens, Sonja Mackey, Haifeng Wu
  • Compounds and methods for preparing methanesulfonamides
    Publication number: 20050148796
    Abstract: A process for preparing (S)-(?)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide(I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
    Type: Application
    Filed: February 28, 2005
    Publication date: July 7, 2005
    Inventors: Sonja MacKey, Michael Matison, Haifeng Wu, Michael Goble, Moses McMillan, Vikram Kalthod
  • Steroid spirolactonization
    Publication number: 20050090663
    Abstract: A steroid comprising a 17-spirolactone or corresponding open lactone structure is obtained by carbonylation of a 17-alkenyl or 17-alkynyl substrate. A 17-alkenyl intermediate may be prepared by semi-hydrogenation of a 17-alkynyl group. Multiple reaction schemes are disclosed for preparation of a 3-keto-9,11-epoxy-17-spirolactone steroid such as eplerenone. Novel intermediates are also disclosed, as well as steps for forming such novel intermediates, or converting them to further intermediates or products, by semi-hydrogenation, carbonylation, 6,7-dehydrogenation, furylation or other transformations or combinations thereof.
    Type: Application
    Filed: March 22, 2004
    Publication date: April 28, 2005
    Applicant: Pharmacia Corporation
    Inventors: Thaddeus Franczyk, Grace Wagner, Bruce Pearlman, Amphlett Padilla, Jeffrey Havens, Sonja Mackey, Haifeng Wu