Patents by Inventor Sonoko Suzuki
Sonoko Suzuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120058511Abstract: The present invention provides a method for producing the peptides comprising: cultivating in medium the microorganisms wherein at least one gene selected from the group consisting of a gene encoding; aminoacylhistidine peptidase; a gene encoding leucylaminopeptidase; and a gene encoding isoaspartyldipeptidase, respectively; has been disrupted on the chromosome and wherein preferably transformed with the recombinant DNA, comprising polynucleotide encoding the proteins having peptide-synthesizing activity, mixing at least one of the cultivated microorganisms and the disrupted cells of the microorganisms with the carboxy and amine components for the peptide synthesis.Type: ApplicationFiled: July 1, 2010Publication date: March 8, 2012Applicant: AJINOMOTO CO., INC.,Inventors: Ikuo KIRA, Kenzo Yokozeki, Sonoko Suzuki, Yasuhiro Mihara, Yoshinori Hirao
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Patent number: 7754466Abstract: The present invention provides a method of producing a dipeptide from starting materials that are available at low costs through a route industrially advantageous and simple. Dipeptides are produced from amino acid esters and amino acids by using a culture of a microbe having an ability to produce a dipeptide from an amino acid ester and an amino acid, microbial cells separated from the culture, or treated microbial cell product.Type: GrantFiled: July 26, 2002Date of Patent: July 13, 2010Assignee: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Sonoko Suzuki
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Patent number: 7749742Abstract: A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.Type: GrantFiled: November 15, 2007Date of Patent: July 6, 2010Assignee: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Sonoko Suzuki, Seiichi Hara, Isao Abe
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Patent number: 7618796Abstract: The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.Type: GrantFiled: October 31, 2006Date of Patent: November 17, 2009Assignee: Ajinomoto Co., Inc.Inventors: Naoto Tonouchi, Sonoko Suzuki, Kenzo Yokozeki, Hiroyuki Nozaki, Masakazu Sugiyama
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Publication number: 20080171357Abstract: A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.Type: ApplicationFiled: November 15, 2007Publication date: July 17, 2008Applicant: AJINOMOTO CO., INC.Inventors: Kenzo YOKOZEKI, Sonoko SUZUKI, Seiichi HARA, Isao ABE
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Patent number: 7338780Abstract: A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.Type: GrantFiled: May 21, 2004Date of Patent: March 4, 2008Assignee: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Sonoko Suzuki, Seiichi Hara, Isao Abe
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Publication number: 20070292916Abstract: The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2.Type: ApplicationFiled: June 20, 2007Publication date: December 20, 2007Applicant: Ajinomoto Co., Inc.Inventors: Isao ABE, Rie Takeshita, Seiichi Hara, Sonoko Suzuki, Kenzo Yokozeki, Masakazu Sugiyama, Shunichi Suzuki, Kunihiko Watanabe, Nobuhisa Shimba, Takefumi Nakamura, Uno Tagami, Yuya Kodama, Hiromi Onoye, Reiko Yuuji, Eiichiro Suzuki, Tatsuki Kashiwagi, Ningchun Xu, Yuko Kai
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Patent number: 7288388Abstract: The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.Type: GrantFiled: January 26, 2004Date of Patent: October 30, 2007Assignee: Ajinomoto Co., Inc.Inventors: Naoto Tonouchi, Sonoko Suzuki, Kenzo Yokozeki, Hiroyuki Nozaki, Masakazu Sugiyama
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Publication number: 20070190602Abstract: The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2.Type: ApplicationFiled: December 27, 2005Publication date: August 16, 2007Applicant: AJINOMOTO CO., INCInventors: Isao Abe, Rie Takeshita, Seiichi Hara, Sonoko Suzuki, Kenzo Yokozeki, Masakazu Sugiyama, Shunichi Suzuki, Kunihiko Watanabe, Nobuhisa Shimba, Takefumi Nakamura, Uno Tagami, Yuya Kodama, Hiromi Onoye, Reiko Yuuji, Eiichiro Suzuki, Tatsuki Kashiwagi, Ningchun Xu, Yuko Kai
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Publication number: 20070048838Abstract: The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.Type: ApplicationFiled: October 31, 2006Publication date: March 1, 2007Applicant: AJINOMOTO CO., INCInventors: Naoto Tonouchi, Sonoko Suzuki, Kenzo Yokozeki, Hiroyuki Nozaki, Masakazu Sugiyama
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Publication number: 20070042459Abstract: A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino acid amide and the L-amino acid, microbial cells separated from the culture or a treated microbial cell product from the microbe. An L-amino acid amide hydrolase is obtained from a microbe belonging to the genus erwinia, genus Rhodococcus, genus Chryseobacterium, genus Micrococcus, genus Cryptococcus, genus Trichosporion, genus Rhodosporidium, genus Sporobolomyces, genus Tremela, genus Torulaspora, genus Sterigmatomyces or genus Rhodotorula. The hydrolase catalyzes a reaction that produces a dipeptide from an L-amino acid amide and an L-amino acid.Type: ApplicationFiled: October 14, 2005Publication date: February 22, 2007Applicant: Ajinomoto Co., Inc.Inventors: Hiroyuki Nozaki, Ikuo Kira, Sonoko Suzuki, Kenzo Yokozeki
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Publication number: 20060188976Abstract: The present invention is to provide an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. A peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II): (I) The mutant protein having the amino acid sequence containing one or more mutations of the above mutations 1 to 38 in the amino acid sequence described in SEQ ID NO:2; and (II) The mutant protein having the amino acid sequence containing one or more mutations selected from the group consisting of substitution, deletion, insertion, addition and inversion at positions other than one or more mutation positions of the above mutation 1 to 38 in the mutant protein described in the above (I), and having a peptide-synthesizing activity.Type: ApplicationFiled: December 20, 2005Publication date: August 24, 2006Applicant: AJINOMOTO CO. INCInventors: Rie Takeshita, Isao Abe, Masakazu Sugiyama, Kenzo Yokozeki, Seiichi Hara, Sonoko Suzuki, Shunichi Suzuki, Kunihiko Watanabe
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Patent number: 7037673Abstract: A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino acid amide and the L-amino acid, microbial cells separated from the culture or a treated microbial cell product from the microbe. An L-amino acid amide hydrolase is obtained from a microbe belonging to the genus erwinia, genus Rhodococcus, genus Chryseobacterium, genus Micrococcus, genus Cryptococcus, genus Trichosporion, genus Rhodosporidium, genus Sporobolomyces, genus Tremela, genus Torulaspora, genus Sterigmatomyces or genus Rhodotorula. The hydrolase catalyzes a reaction that produces a dipeptide from an L-amino acid amide and an L-amino acid.Type: GrantFiled: July 26, 2002Date of Patent: May 2, 2006Assignee: Ajinomoto Co., Inc.Inventors: Hiroyuki Nozaki, Ikuo Kira, Sonoko Suzuki, Kenzo Yokozeki
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Publication number: 20050176150Abstract: The present invention provides a method for producing the peptides comprising: cultivating in medium the microorganisms wherein at least one gene selected from the group consisting of a gene encoding; aminoacylhistidine peptidase; a gene encoding leucylaminopeptidase; and a gene encoding isoaspartyldipeptidase, respectively; has been disrupted on the chromosome and wherein preferably transformed with the recombinant DNA, comprising polynucleotide encoding the proteins having peptide-synthesizing activity, mixing at least one of the cultivated microorganisms and the disrupted cells of the microorganisms with the carboxy and amine components for the peptide synthesis.Type: ApplicationFiled: February 7, 2005Publication date: August 11, 2005Applicant: Ajinomoto Co., Inc.Inventors: Ikuo Kira, Kenzo Yokozeki, Sonoko Suzuki, Yasuhiro Mihara, Yoshinori Hirao
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Publication number: 20050054067Abstract: A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino acid amide and the L-amino acid, microbial cells separated from the culture or a treated microbial cell product from the microbe. An L-amino acid amide hydrolase is obtained from a microbe belonging to the genus erwinia, genus Rhodococcus, genus Chryseobacterium, genus Micrococcus, genus Cryptococcus, genus Trichosporion, genus Rhodosporidium, genus Sporobolomyces, genus Tremela, genus Torulaspora, genus Sterigmatomyces or genus Rhodotorula. The hydrolase catalyzes a reaction that produces a dipeptide from an L-amino acid amide and an L-amino acid.Type: ApplicationFiled: July 26, 2002Publication date: March 10, 2005Inventors: Hiroyuki Nozaki, Ikuo Kira, Sonoko Suzuki, Kenzo Yokozeki
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Publication number: 20050037453Abstract: The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.Type: ApplicationFiled: January 26, 2004Publication date: February 17, 2005Applicant: AJINOMOTO CO. INCInventors: Naoto Tonouchi, Sonoko Suzuki, Kenzo Yokozeki, Hiroyuki Nozaki, Masakazu Sugiyama
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Publication number: 20050032187Abstract: The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter, and a method was found that allows peptides to be produced inexpensively and easily.Type: ApplicationFiled: February 11, 2004Publication date: February 10, 2005Applicant: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Sonoko Suzuki, Seiichi Hara, Satoshi Katayama
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Publication number: 20050032154Abstract: It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium. In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.Type: ApplicationFiled: June 3, 2004Publication date: February 10, 2005Applicant: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Sonoko Suzuki, Seiichi Hara, Isao Abe
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Publication number: 20040253665Abstract: The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter, and a method was found that allows peptides to be produced inexpensively and easily.Type: ApplicationFiled: April 8, 2004Publication date: December 16, 2004Applicant: AJINOMOTO CO., INC.Inventors: Kenzo Yokozeki, Sonoko Suzuki, Seiichi Hara, Satoshi Katayama
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Publication number: 20040219631Abstract: A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.Type: ApplicationFiled: May 21, 2004Publication date: November 4, 2004Applicant: Ajinomoto Co., Inc.Inventors: Kenzo Yokozeki, Sonoko Suzuki, Seiichi Hara, Isao Abe