Publication number: 20130029967
Abstract: There is provided compounds of formula (I), wherein A1, A2, A3, A4, n, the dotted lines, B1, B1a, B2, B2a, B3, B3a, B4, B4a, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
Type:
Application
Filed:
September 24, 2010
Publication date:
January 31, 2013
Applicant:
Centro Nacional de Investigaciones Oncologicas (CNIO)
Inventors:
Joaquin Pastor Fernández, Sonia Martinez Gonzalez, Rosa Maria Alvarez Escobar, Sonsoles Rodriguez Aristegui, Esther Gonzales Cantalapiedra, Ana Isabel Hernandez Higueras, Carmen Varela Busto