Patents by Inventor Sonsoles Velázquez Díaz

Sonsoles Velázquez Díaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs cleavable by CD26
    Patent number: 8236756
    Abstract: The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjugates of a therapeutic compound and a peptide (eg tetrapeptide or hexapeptide) wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptidase IV). The present invention furthermore provides a method of producing the prodrugs, to enhance brain and lymphatic delivery of drugs and/or to extend drug half-lives in plasma.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: August 7, 2012
    Assignees: Consejo Superior de Investigaciones Clentificas (CSIC), K.U. Leuven Research & Development
    Inventors: Jan Balzarini, Maria José Camarasa Ríus, Sonsoles Velázquez Díaz