Abstract: A method of measuring edema (e.g., peripheral edema and/or lymphedema) is described. The method involves directing a pulse of compressed air or other gas at a skin surface and determining the level of edema using processed camera images of the skin surface after indentation with the compressed air or other gas. The method can be completed within minutes, is simple to perform, and is free of user bias. Devices and systems for measuring edema and/or one or more skin-related properties are also described. The devices can be portable and suitable for use in medical or veterinary settings as well as for in-home/personal use.