Patents by Inventor Soo Ching Niki Cecilia Wong

Soo Ching Niki Cecilia Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR EXPRESSING SIALYLATED GLYCOPROTEINS IN MAMMALIAN CELLS AND CELLS THEREOF
    Publication number: 20090298120
    Abstract: Methods and systems for producing glycoproteins having sialylated oligosaccharides are provided. The invention comprises the genetic engineered cells with a CMP-sialic acid transporter (CMP-SAT) gene so that the cells express the CMP-SAT protein or fragment thereof at an above endogenous levels. The increase in CMP-SAT expression allows for the increased transport of the CMP-sialic acid into the Golgi apparatus so as to obtain sialylation of glycoproteins at above endogenous levels. In particular, the methods and systems of the invention are useful for producing complex sialylated glycoproteins in mammalian cells of interest, for example Chinese Hamster Ovary (CHO) cells.
    Type: Application
    Filed: May 4, 2005
    Publication date: December 3, 2009
    Applicants: NATIONAL UNIVERSITY OF SINGAPORE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Soo Ching Niki Cecilia Wong, Gek Sim Miranda Yap, I-Chyau Daniel Wang