Patents by Inventor Soo-Keun Choi
Soo-Keun Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11970493Abstract: The present disclosure provides autotaxin (ATX) inhibitor compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for inhibiting ATX. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.Type: GrantFiled: October 4, 2021Date of Patent: April 30, 2024Assignee: ILDONG PHARMACEUTICAL CO., LTD.Inventors: Sung-Ku Choi, Yoon-Suk Lee, Sung-Wook Kwon, Kyung-Sun Kim, Jeong-Geun Kim, Jeong-Ah Kim, An-Na Moon, Sun-Young Park, Jun-Su Ban, Dong-Keun Song, Kyu-Sic Jang, Ju-Young Jung, Soo-Jin Lee
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Patent number: 8329430Abstract: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, ATCC21830 and F4 strains, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.Type: GrantFiled: March 19, 2010Date of Patent: December 11, 2012Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Seung-Hwan Park, Jihyun F Kim, ChoongHwan Lee, Soo-Keun Choi, Heayoung Jeong, Seong-Bin Kim, Yon Kyoung Park, Rumi Kim, Choong-Min Ryu, Soo-Young Park
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Patent number: 8030064Abstract: The present invention relates to a method for expressing a target protein on an exosporium forming the outermost surface of bacterial spores. More particularly, the present invention relates to a method for expressing a target protein on the surface of cells and spores using an exosporium as a matrix for surface expression, and methods for the production of a protein array, the production of antibodies, the separation of a certain substance from a mixture, bioconversion, and the improvement of a target protein, which are characterized by using the cells or spores having the target protein that was expressed on the surface by the above expression method.Type: GrantFiled: December 30, 2003Date of Patent: October 4, 2011Assignees: Korea Advanced Institute of Science and Technology, Genofocus, Inc.Inventors: Sang Yup Lee, Tae Jung Park, Jong Pil Park, Seok Jae Lee, Jae-Gu Pan, Heung-Chae Jung, Soo-Keun Choi
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Publication number: 20100279347Abstract: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, ATCC21830 and F4 strains, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.Type: ApplicationFiled: March 19, 2010Publication date: November 4, 2010Applicant: Korea Research Institute of Bioscience and BiotechnologyInventors: Seung-Hwan Park, Jihyun F. Kim, ChoongHwan Lee, Soo-Keun Choi, Heayoung Jeong, Seong-Bin Kim, Yon Kyoung Park, Rumi Kim, Choong-Min Ryu, Soo-Young Park
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Patent number: 7811790Abstract: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.Type: GrantFiled: November 8, 2006Date of Patent: October 12, 2010Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Seung-Hwan Park, Jihyun F. Kim, ChoongHwan Lee, Soo-Keun Choi, Heayoung Jeong, Seong-Bin Kim, Yon Kyoung Park, Rumi Kim, Choong-Min Ryu, Soo-Young Park
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Publication number: 20090226964Abstract: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.Type: ApplicationFiled: November 8, 2006Publication date: September 10, 2009Applicant: Korea Research Instituteof Bioscience and BiotechnologyInventors: Seung-Hwan Park, Jihyun F. Kim, ChoongHwan Lee, Soo-Keun Choi, Heayoung Jeong, Seong-Bin Kim, Yon Kyoung Park, Rumi Kim, Choong-Min Ryu, Soo-Young Park
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Patent number: 7582426Abstract: The present invention relates to a method for display of proteinson spore surface and a method for improving protein with rapidity using the same, which comprises the steps of (i) preparing a vector for spore surface display comprising a gene construct containing a gene encoding spore coat protein and a gene encoding a protein of interest, wherein, when expressed, the gene construct expresses a fusion protein between the spore coat protein and the protein of interest, (ii) transforming a host cell with the vector for spore surface display; (iii) displaying the protein of interest on a surface of a spore of the host cell; and (iv) recovering the spore displaying on its surface the protein of interest.Type: GrantFiled: December 7, 2001Date of Patent: September 1, 2009Assignee: Geneofocus Co., Ltd.Inventors: June-Hyung Kim, Byung-Gee Kim, Soo-Keun Choi, Heung-Chae Jung, Jae-gu Pan
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Publication number: 20070269838Abstract: The present invention relates to a method for expressing a target protein on an exosporium forming the outermost surface of bacterial spores. More particularly, the present invention relates to a method for expressing a target protein on the surface of cells and spores using an exosporium as a matrix for surface expression, and methods for the production of a protein array, the production of antibodies, the separation of a certain substance from a mixture, bioconversion, and the improvement of a target protein, which are characterized by using the cells or spores having the target protein that was expressed on the surface by the above expression method.Type: ApplicationFiled: December 30, 2003Publication date: November 22, 2007Inventors: Sang Lee, Tae Park, Jong Park, Seok Lee, Jae-Gu Pan, Heung-Chae Jung, Soo-Keun Choi
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Publication number: 20050176096Abstract: The present invention relates to a biocatalyst displayed on spore or virus surface and a method of bioconversion using the same, in particular to a method of bioconversion using a biocatalyst, which comprises the steps of: (a) preparing a vector for spore surface display comprising a gene construct containing a gene encoding a display motif and a gene encoding the biocatalyst, wherein, when expressed, the gene construct expresses the display motif and the biocatalyst in a fusion form and the biocatalyst is displayed on a spore surface; (b) transforming a host cell with the vector for spore surface display; (c) displaying the biocatalyst on the spore surface of the host cell; (d) recovering the spore displaying on its surface the biocatalyst; and (e) performing the bioconversion reaction using the spore displaying on its surface the biocatalyst, and a biocatalyst.Type: ApplicationFiled: April 9, 2002Publication date: August 11, 2005Inventors: Seok-Joon Kwon, Soo Keun Choi, Heung Chae Jung, Jae Gu Pan, Joon Sung Chang, Tae Jung Park
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Publication number: 20040180348Abstract: The present invention relates to methods for preparing a protein of interest surface-displayed on genetic carrier, for improving a protein of interest, for isolating a substance of interest, bioconversion and producing antibody. More particularly, the present invention relates to a method for preparing a protein of interest surface-displayed on genetic carrier, which comprises the steps of: (a) transforming a host cell harboring the genetic carrier selected from the group consisting of spore and virus with a vector containing a gene encoding the protein of interest; (b) culturing the transformed host cell and expressing the protein of interest in the host cell; and (c) allowing to form noncovalent bond between the expressed protein and a surface of the genetic carrier so that the protein of interest is displayed on the surface of the genetic carrier.Type: ApplicationFiled: April 26, 2004Publication date: September 16, 2004Inventors: Jae-Gu Pan, Soo-Keun Choi, Heung-Chae Jung
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Publication number: 20040171065Abstract: The present invention relates to a method for display of proteinson spore surface and a method for improving protein with rapidity using the same, which comprises the steps of (i) preparing a vector for spore surface display comprising a gene construct containing a gene encoding spore coat protein and a gene encoding a protein of interest, wherein, when expressed, the gene construct expresses a fusion protein between the spore coat protein and the protein of interest, (ii) transforming a host cell with the vector for spore surface display; (iii) displaying the protein of interest on a surface of a spore of the host cell; and (iv) recovering the spore displaying on its surface the protein of interest.Type: ApplicationFiled: June 5, 2003Publication date: September 2, 2004Inventors: June-Hyung Kim, Byung-Gee Kim, Soo-Keun Choi, Heung-Chae Jung, Jae-Gu Pan