Abstract: The present disclosure relates to targeted genome editing in eukaryotic cells or organisms. More particularly, the present disclosure provides for compositions and methods that may induce modifications in target endogenous nucleic acid sequences in nucleuses of eukaryotic cells. For example, disclosed herein is a system for inducing targeted disruption of endogenous genes in a eukaryotic cell, the system comprising: an extracellular Cas9/RNA complex; cell-free and a buffer; wherein the extracellular Cas9/RNA complex comprises: a recombinant Cas9; and a guide RNA having a CRISPR RNA (crRNA) and a transactivating crRNA (tracrRNA); wherein the extracellular Cas9/RNA complex is disposed in the cell-free buffer and wherein the extracellular Cas9/RNA complex is complexed prior to being introduced into the eukaryotic cell; and wherein the Cas9/RNA complex functions as an endonuclease that induces targeted disruption of the target DNA upon introduction into the eukaryotic cell.

Abstract: Provided is a method and an apparatus for targeting an object in a game. The method of targeting an object in a game includes: setting a center point of a first targeting area based on a first input from a user; displaying the first targeting area surrounded by a closed curve around the center point on a screen of a user terminal; displaying a list including at least one object located in the first targeting area on the screen; and moving the first targeting area based on a second input by the user received after the first input.

Abstract: The present disclosure relates to targeted genome editing in eukaryotic cells or organisms. More particularly, the present disclosure provides for compositions and methods that may induce modifications in target endogenous nucleic acid sequences in nucleuses of eukaryotic cells.

Abstract: A method of processing speech includes: obtaining a speech input; obtaining an instruction related to the speech input; obtaining a speech representation corresponding to the speech input; obtaining an adapter that includes speech information by fusing a pre-trained adapter with the speech representation; and obtaining a response corresponding to the instruction by inputting both the adapter that includes the speech information and the instruction to a language model, the language model generating the response based on the adapter that includes the speech model and the speech information.

Abstract: Provided is a zinc alloy-plated steel material having excellent corrosion resistance and surface qualities. The steel material includes: a base steel; a zinc alloy-plating layer formed on the base steel, wherein the zinc alloy-plating layer comprises, by weight %, 8 to 25% of aluminum (Al), 4 to 12% of magnesium (Mg), and a balance of zinc (Zn) and inevitable impurities; and a polygonal solidification phase formed in a surface of the zinc alloy-plating layer and having a substantially straight boundary line between the polygonal solidification phase and a microstructure surrounding the polygonal solidification phase. The substantially straight boundary line forms an angle with an adjacent substantially straight boundary line, and an area fraction occupied by the polygonal solidification phase on the surface of the zinc alloy-plating layer is 20 to 90%.

Abstract: Provided is a hollow swivel actuator including: a lower housing in which a driving motor is arranged; and an upper housing in which three gear trains and three pinion gear units for reduction are arranged at intervals of 120 degrees. A rotor worm gear for transferring an output of the driving motor is coupled through gear engagement to a ring gear integrally formed on a rotational table to transfer reduced rotational power therebetween. The hollow swivel actuator obtains a great reduction ratio by: primary reduction between the rotor worm gear of the driving motor and first to third worm wheels of the first to third gear trains; secondary reduction between first to third worm gears and fourth to sixth worm wheels of the first to third pinion gear units; and tertiary reduction between the ring gear and the first to third pinion gears, thereby achieving a large torque increase.

Abstract: Provided is a water pump using an axial gap-type electric motor employing a rare-earth-free magnet. The water pump (EWP) includes: a pump housing having a space in a sealing state on one side thereof, in which, on the other side thereof, an inlet through which a fluid is introduced and an outlet through which the introduced fluid is discharged are connected through a fluid flow passage; a rotor rotatably supported on the fluid flow passage; an impeller integrally formed with the rotor on the upper side of the rotor; a stator arranged in the lower space to generate a rotating magnetic field to rotatably drive the rotor; and a waterproof partition wall arranged inside the pump housing to separate the rotor from the stator.

Abstract: The present invention relates to a method of preparing a polymer, which includes: adding a first reaction solution including an aqueous solvent and a monomer mixture including an alkyl-substituted aromatic vinyl-based monomer, an alkyl-unsubstituted aromatic vinyl-based monomer, and a vinyl cyanide-based monomer to a reactor and initiating polymerization; and performing polymerization by continuously adding an alkyl-substituted aromatic vinyl-based monomer to the reactor, wherein the first reaction solution satisfies Expression 1 (see the description of the invention).

Abstract: An apparatus for estimating blood pressure may include: a photoplethysmogram (PPG) sensor configured to measure a PPG signal from a user; and a processor configured to: extract a cardiovascular feature from the PPG signal; calculate a first variation in the extracted cardiovascular feature compared to a reference cardiovascular feature measured at a reference time; determine a measurement posture of the PPG signal based on a time interval between two waveform components of the PPG signal; in response to the measurement posture corresponding to the reference posture, estimate the blood pressure based on the first variation; and in response to the measurement posture not corresponding to the reference posture, obtain a second variation by correcting the first variation; and estimate blood pressure based on the second variation.

Abstract: Embodiments relate to a Brillouin distributed optical fiber sensor including a first light source to output a first light having a modulated intensity at a preset frequency, an optical modulation unit to generate Brillouin probe light and Brillouin pump light using the first light and apply the Brillouin probe light and the Brillouin pump light to one end and the other end of a test optical fiber, respectively, a second light source to apply a second light with a frequency that is different from a frequency of the first light to one end of the test optical fiber in a direction opposite to the Brillouin pump light, and an optical detection unit to detect Brillouin scattered light generated by interaction between the Brillouin pump light and the Brillouin probe light in the test optical fiber.

Abstract: A computer-implemented method for spatially tracking muscle activity is disclosed. A muscle activation signal is received from a muscle activation sensor. The muscle activation signal indicates an amount of muscle activation of a muscle associated with a body part. A spatial signal is received from a spatial sensor. The spatial signal indicates a location of the body part in a physical space. Activation data is data that spatially correlates the amount of muscle activation of the body part to the location of the body part in the physical space.

Abstract: A semiconductor device includes: a sampling control circuit configured to select a coarse section from a plurality of coarse sections according to a first pattern signal during a sampling period, select a fine section from a plurality of fine sections according to a second pattern signal during the selected coarse section, and generate first to third sampling control signals having activated sections defined by the selected coarse section and the selected fine section; and a sampling circuit configured to sample an input address according to the first to third sampling control signals, respectively, to generate first to third sampling addresses, and schedule the first to third sampling addresses according to a sampling signal defining the sampling period to output an output address.

Abstract: A semiconductor device includes: a substrate; a gate stacking structure that includes interlayer insulating layers and gate electrodes that are alternately stacked on the substrate; a channel structure that penetrates the gate stacking structure and extends in a first direction, and includes a channel layer connected to the substrate and a ferroelectric layer that surrounds the channel layer; a charge inflow pattern disposed on a lateral side of the ferroelectric layer and spaced apart in the first direction; and an insulation pattern disposed between the charge inflow pattern and the gate electrodes and that surrounds an exterior side, a lower side, and an upper side of the charge inflow pattern.

Abstract: Disclosed herein is a slide-type self-ligating orthodontic bracket assembly including: a bracket body block (10) including a base portion (11) configured to be attached to the surface of a tooth, and a body portion (12) formed on the base portion 11 and provided with a wire slot (120), into which the arch wire (W) is inserted, between a first wall (130) and a second wall (140); a cover block (20) configured to slide between an open position for opening the wire slot (120) and a closed position for closing the wire slot (120); and a restraining unit configured to restrain the cover block (20) in the closed position and the open position; wherein a guide protrusion (132), both sides of which are flat surfaces parallel to each other, is formed on the flat top surface of the first wall (130).

Abstract: A separator for a rechargeable lithium battery and a rechargeable lithium battery including the same are disclosed. For example, in an embodiment, provided is a separator for a rechargeable lithium battery including a heat resistant layer and an adhesive layer which are sequentially formed on at least one surface of a substrate, wherein the heat resistant layer includes a ceramic, the adhesive layer includes an adhesive binder and an organic filler, and the adhesive binder includes a polymer having an interpenetrating polymer network (IPN) structure.

Abstract: A battery diagnosing apparatus, a battery pack, an electric vehicle and a battery diagnosing method are provided. The battery diagnosing apparatus is provided for a battery array including first to mth batteries (m is a natural number of 3 or more) connected in series. The battery diagnosing apparatus includes voltage sensors configured to detect voltage of each of the first to mth batteries, and a controller configured to generate first to mth voltage profiles representing a voltage change history of each of the first to mth batteries during charging or discharging of the battery array. The controller diagnoses the battery array by comparing each of first to (m?1)th comparison voltage profiles with a criterion voltage profile. The criterion voltage profile is one of the first to mth voltage profiles, and the first to (m?1)th comparison voltage profiles are remaining (m?1) voltage profiles other than the criterion voltage profile.

Abstract: A wireless system including a wireless station and an automatic frequency adjustment system and a method for controlling the same are disclosed. According to one embodiment of the present disclosure, the wireless system may include a wireless station including a beacon demodulator and an automatic frequency adjustment system having a database including identification information of a plurality of wireless local area network (LAN) access points (Aps), and the wireless station may be configured to: obtain information related to a first beacon frame by demodulating the first beacon frame transmitted from a first wireless LAN AP through the beacon demodulator and transmit the information related to the first beacon frame to the automatic frequency adjustment system.

Abstract: Various embodiments for techniques for providing a Time Sensitive Network (TSN) transmission function in a mobile communication system are disclosed. In one embodiment, a method of operating an electronic device performing AMF in a mobile communication system may comprise obtaining information about the TSN talker and listener capabilities of a RAN in the mobile communication system; and transmitting the obtained information to an electronic device performing CUC co-located with SMF.

Abstract: A battery cell classification system may include a charging voltage differential value measurement device configured to determine a charging voltage differential value of a battery cell before assembling a battery module, a uniformity factor extractor configured to extract a uniformity factor based on determining uniformity of the battery cell among determined charging voltage differential values, and a controller configured to compare a uniformity factor of the battery cell with a reference uniformity value, so as to reject the battery cell as a defective cell if it has the uniformity value smaller than the reference uniformity value, or to classify battery cell based on uniformity factor if it has the uniformity value at or above than the reference uniformity value.

Abstract: A secondary battery electrode and a method of manufacturing a secondary battery electrode are disclosed. A secondary battery electrode includes an electrode plate body including a first area and a second area, an active material layer on the first area, a ceramic layer on the second area, a coupling portion located in the second area, and a tab welded to the coupling portion.