Abstract: The present invention provides a thermosensitive liposome which permits temperature-sensitive drug release and exhibits variable release temperatures. The process for preparing a thermosensitive liposome of the invention, comprises a step of coating the surface of a liposome with a copolymer of N-isopropylacrylamide/octadecylacrylate/acrylic acid, by the addition of the copolymer to the liposome suspension in a weight ratio of 1:0.05 to 1:0.2 (liposome:copolymer), and the incubation of the polymer-liposome suspension at a temperature range of 0.degree. to 10.degree. C., for 10 to 14 hours. The thermosensitive liposome of the present invention is able to control the temperature of drug release at a temperature range of above 28.degree. C., preferably at 28.degree. to 36.degree. C., depending on the acrylic acid content in the copolymer of N-isopropylacrylamide/octadecylacrylate/acrylic acid.