Patents by Inventor Soo Young Jun

Soo Young Jun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for enhancing TRAIL sensitivity comprising inhibitors for expression or activity of TIP41 as a target gene of TRAIL sensitizer
    Patent number: 8703732
    Abstract: The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: April 22, 2014
    Assignee: Korea Research Institute of Bioscience and Biotech
    Inventors: Nam-Soon Kim, In-Sung Song, Cheol-Hee Kim, Ga Hee Ha, Hyun-Taek Kim, So-Young Jeong, Jeong-Min Kim, Joo Heon Kim, Jin-Man Kim, Soo Young Jun
  • COMPOSITION FOR ENHANCING TRAIL SENSITIVITY COMPRISING INHIBITORS FOR EXPRESSION OR ACTIVITY OF TIP41 AS A TARGET GENE OF TRAIL SENSITIZER
    Publication number: 20120315284
    Abstract: The present invention relates to a pharmaceutical composition, including inhibitors for expression or activity of TIP41 protein, for prevention and treatment of cancer. When the liver cancer cell lines, showing resistance to TRAIL, are treated with TIP41 siRNA and TRAIL, apoptosis is induced in cancer cell. The same effect is found in cases of lung cancer and colon cancer with resistance against TRAIL. Moreover, this induction of apoptosis by TIP41 siRNA and TRAIL was confirmed in tumor xenograft, which was injected with Huh7 liver cancer cells and then was subjected to TIP41 siRNA transfection and TRAIL treatment. In addition, it was confirmed through animal experiments in which the tumor size has reduced and apoptosis was induced by treatment with TIP41 siRNA and TRAIL. Of note, MKK7/JNK pathway was confirmed to mediate the apoptosis induced by the application of TIP41 siRNA and TRAIL. The apoptosis were verified to be caused by the activation of MKK7/JNK signaling pathway.
    Type: Application
    Filed: April 1, 2011
    Publication date: December 13, 2012
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECH
    Inventors: Nam-Soon Kim, In-Sung Song, Cheol-Hee Kim, Ga Hee Ha, Hyun-Taek Kim, So-Young Jeong, Jeong-Min Kim, Joo Heon Kim, Jin-Man Kim, Soo Young Jun