Abstract: The present disclosure provides autotaxin (ATX) inhibitor compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for inhibiting ATX. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Abstract: The inventive concept provides a method for treating a substrate. The method includes removing a film on the substrate by applying a pulsed laser to the rotating substrate, in which thickness of the film to be removed is measured and pulse energy of the pulsed laser is selected based on the measured thickness of the film.

Abstract: A rendering method of an object-based audio signal and an apparatus for performing the same are provided. The rendering method of an object-based audio signal includes obtaining a rendered audio signal, performing clipping prevention on the rendered audio signal using a first limiter, mixing a signal output by the first limiter using a mixer, and performing clipping prevention on the mixed signal using a second limiter.

Abstract: A method of rendering object-based audio and an electronic device performing the method are provided. The method includes identifying a bitstream, determining a reference distance of an object sound source based on the bitstream, determining a minimum distance for applying distance-dependent attenuation, based on the reference distance, and determining a gain of object-based audio included in the bitstream based on the reference distance and the minimum distance.

Abstract: The present invention provides a recombinant expression vector comprising a gene encoding canine parvovirus 2a VP2 or 2b VP2 protein, a recombinant plant into which the vector is transformed, a vaccine composition against canine parvovirus, comprising canine parvovirus 2a VP2 or 2b VP2 protein obtained from the recombinant plant, and a composition for diagnosing canine parvovirus. When the recombinant plant of the present invention is used, canine parvovirus 2a VP2 or 2b VP2 antigen protein can be rapidly produced with high efficiency. Since the composition for diagnosing canine parvovirus according to the present invention uses a recombinant antigen protein, there is no possibility of contamination due to live virus handling, and thus the composition is safe, and the presence or absence of canine parvovirus infection can be rapidly diagnosed from a large amount of samples.

Abstract: Provided is a Raman scattering measurement apparatus including a light source which emits light to smoke particles, a filter configured to block light which is incident to the smoke particles and passes through the particle and to allow Raman scattered light to pass therethrough, and a photodetector which detects the Raman scattered light passing through the filter in order to distinguish fire smoke generated due to a true fire from non-fire smoke generated due to daily life or industrial activity. The present invention also provides a fire determination apparatus including a unit which reads a Raman shift from Raman scattered light detected by the photodetector of the Raman scattering measurement apparatus, estimates a smoke component from the read Raman shift, and determines fire/non-fire from the estimated smoke component and a method thereof.

Abstract: The present invention relates to a method and system for providing language learning services. The method of providing language learning services, according to the present invention, the method may include: activating, in response to receiving an input for acquiring a learning target image through a user terminal, a camera of the user terminal; specifying at least a portion of an image taken by the camera as the learning target image; receiving language learning information for the learning target image from a server; providing the language learning information to the user terminal; and storing, based on a request for storing of the language learning information, the language learning information in association with the learning target image, such that the learning target image is used in conjunction with learning of the language learning information.

Abstract: The present disclosure relates to a novel PLK1 degradation inducing compound having a structure according to Formula I, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.

Abstract: One embodiment discloses a DC-DC converter which, in a solar-related energy storage system, cuts-off the over-discharging of a battery, and a control method thereof. Specifically, disclosed are a DC-DC converter which protects a battery by appropriately switching between a sleep mode which minimizes battery consumption by maintaining only minimized functions and a cut-off mode which prevents the battery from over-discharging by physically cutting off a circuit connected to the battery, and a control method thereof. Also, an embodiment discloses a DC-DC converter or reverse wiring protection device for between a solar panel and a battery.

Abstract: Embodiments of the current disclosure to provide a display device which can reduce the number of intersections of scan lines and data lines. According to an embodiment of the disclosure, a display device comprises: a substrate; scan lines extending along a first direction; data lines extending along a second direction that intersect the first direction; a first switching element; a first pixel electrode connected to a first source electrode of the first switching element; a second switching element; and a second pixel electrode connected to a second source electrode of the second switching element. The first pixel electrode and the second pixel electrode are disposed along the second direction, and a first source electrode and a first drain electrode of the first switching element extend along the second direction in an area overlapping a first active layer of the first switching element.

Abstract: The present invention relates to an immunogenic composition including multivalent pneumococcal polysaccharide-protein conjugates. Each conjugate includes capsular polysaccharides of different pneumococcus serotypes conjugated to a carrier protein. More concretely, the present invention is a multivalent immunogenic composition including polysaccharide-protein conjugates. Each of the polysaccharide-protein conjugates includes Streptococcus pneumoniae-derived capsular polysaccharides of different serotypes conjugated to a carrier protein. The capsular polysaccharides include a) capsular polysaccharides of one or more serotypes selected from the group consisting of serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, and b) capsular polysaccharides of one or more serotypes selected from the group consisting of serotypes 10A, 11A, 12F, 15B, 22F, 23A, and 35B.

Abstract: The present disclosure relates to a novel PLK1 degradation inducing compound having a structure according to Formula I, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.

Abstract: The present application relates to a composition for preventing or treating osteoarthritis, including an osteoclast-associated Ig-like receptor (OSCAR) protein inhibitor, a polynucleotide encoding an anti-OSCAR antibody or a fragment thereof, and an OSCAR protein inhibitor screening method. According to embodiments of the present application, the anti-osteoclast-associated Ig-like receptor (OSCAR) antibody or a fragment thereof of the present application may prevent or treat osteoarthritis through a mechanism for inhibiting the OSCAR-collagen interaction in chondrocytes, and an OSCAR protein inhibitor having an excellent effect of inhibiting the OSCAR-collagen interaction can be screened by using the OSCAR protein inhibitor screening method of the present application.

Abstract: A method and system for generating a target map for training a neural network and obtaining a sound source map regardless of the maximum number of sound sources, having a short computation time for inference, high spatial resolution and high sound source accuracy. The method includes generating grids each having a spacing within a given range at positions where sound sources are present in order to form a sound source map, calculating a result value for each of coordinates of the grids so that the result value is a local maximum at the position of a sound source and the result value decreases depending on the distance from the sound source, arranging the result values at positions on matrices corresponding to the respective coordinates of the grids, and generating a target map having an image form by using the result values arranged in on the matrices.

Abstract: A water-softening system includes a filter device including filter units that are provided in at least some of a plurality of supply channels arranged in parallel to supply raw water to a consumption site and that remove at least part of ionic matter contained in supplied raw water by electro-deionization and discharge soft water containing less ionic matter than the raw water, a plurality of supply valves provided in the plurality of supply channels to open or close the supply channels, and a processor connected to the filter device and the plurality of supply valves. The processor determines whether water is supplied to the consumption site and controls at least one of the plurality of supply valves to remain open to maintain a state in which water is allowed to be supplied to the consumption site, when it is determined that no water is supplied to the consumption site.

Abstract: The present invention relates to a binding molecule that binds to SARS-coronavirus-2 (SARS-CoV-2). More particularly, the binding molecule of the present invention has strong ability to bind to a spike protein (S protein) on the surface of SARS-coronavirus-2 and high neutralizing activity against SARS-coronavirus-2 and is thus very useful in the diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19).

Abstract: The present invention relates to a Varicella zoster virus fusion protein and an immunogenic composition comprising same and, more specifically, to a fusion protein comprising the glycoprotein E (gE) of Varicella zoster virus (VZV) and a constant region of an immunoglobulin molecule, and an immunogenic composition comprising same. The present invention not only remarkably increases a Varicella zoster virus-specific cell-mediated immune response, but also exhibits the effect of rapidly and potently inducing an immune response and sustaining the immune response for a long period of time, compared to preexisting vaccines, thereby can be usefully used to prevent Varicella zoster-related diseases.

Abstract: A water-softening system includes a filter device including filter units that are provided in at least some of a plurality of supply channels arranged in parallel to supply raw water to a consumption site and that remove at least part of ionic matter contained in supplied raw water by electro-deionization and discharge soft water containing less ionic matter than the raw water, a plurality of supply valves provided in the plurality of supply channels to open or close the supply channels, and a processor connected to the filter device and the plurality of supply valves. The processor determines whether water is supplied to the consumption site and controls at least one of the plurality of supply valves to remain open to maintain a state in which water is allowed to be supplied to the consumption site, when it is determined that no water is supplied to the consumption site.

Abstract: The present invention relates to a binding molecule having neutralizing activity against Middle East Respiratory Syndrome-Coronavirus (MERS-CoV). More particularly, the present invention relates to a binding molecule having strong ability to bind to an S protein of MERS-CoV and neutralizing activity against MERS-CoV and thus being very useful in the prevention, treatment or diagnosis of MERS-CoV infection.

Abstract: Disclosed is a water softening system including a first filter unit and a second filter unit that selectively performs a removal mode of discharging soft water that contains a smaller amount of an ionic material than source water or a recycling mode of discharging reclaimed water that contains a larger amount of the ionic material than the source water.