Abstract: The present invention relates to an antibacterial polymer composition containing a polymer compound in which a cationic monomer and a fluorine-based acrylic monomer are graft-polymerized in a fluorine-based copolymer. A fluorine-based polymer composition according to the present specification exhibits an antibacterial effect of 99.9% or more, exhibits a contact angle of 150 degrees or greater with respect to a solvent, and thus can be applied to a coating agent exhibiting high air permeability, contamination resistance, and antibacterial effect.

Abstract: The present disclosure is directed toward drugs or toxins; drug conjugates comprising said drugs or toxins and a cleavable linker; and conjugates comprising said drugs or toxins, cleavable linkers, and cell-binding groups. The present disclosure also relates to methods of treating cancers, autoimmune diseases, and inflammatory diseases using the compounds and conjugates of the disclosure.

Abstract: The present invention relates to an Fe—S fusion protein acting as an electron transport chain, a novel carbon monoxide:formate oxidoreductase (CFOR) including the Fe—S fusion protein, novel Thermococcus strain BCF12 transformed with CFOR, and the use thereof. According to the present invention, two different enzymes may be physically linked directly to each other through the Fe—S fusion protein of the present invention, and thus electrons generated from any one enzyme may be transported directly to another enzyme through the Fe—S cluster of the Fe—S fusion protein. Accordingly, a reaction that produces a target substance with high efficiency by directly supplying electrons necessary for the production of the target substance is possible without leakage of electrons generated in any one enzyme. In addition, the present invention has an advantage in that the overall enzyme reaction rate and yield can be dramatically improved using a new electron transport reaction.

Abstract: The present invention relates to a novel reovirus-based vaccine platform, and confirmed that a part of the S1 gene of reovirus can be replaced with various exogenous epitope-encoding genes, and a recombinant reovirus manufactured according to the present invention not only can infect target cells and induce the expression of the epitope, but also can effectively prevent and treat diseases related to the epitope by activating the immune function of immune cells against the epitope. When using the reovirus-based vaccine platform of the present invention, vaccines containing various epitopes can be manufactured through relatively simple genetic manipulation technology, and can be administered in various ways including oral administration, so it can be utilized for the prevention and treatment of various infectious diseases including SARS-CoV-2 virus infection, and cancer.

Abstract: The present invention relates to a microorganism-based cosmetic composition containing, as an active ingredient, at least one of a fermentation product of Lactococcus lactis, a fermentation product of Limosilactobacillus reuteri, and a fermentation product of Saccharomyces cerevisiae, and containing a fermentation product of Lactiplantibacillus plantarum as an active ingredient, as well as a method for producing the same.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The present disclosure provides compounds and compositions comprising substituted benzodiazepines of the class of Formula I:

Abstract: A method and apparatus for minimizing a time that a camera field of view is not being monitored while the camera is undergoing a software or firmware update is provided herein. During operation a determination is made that a camera needs a software or firmware update. The location of a security asset (e.g., a mobile camera, a security guard, a drone, . . . , etc.) is determined. The update is performed based on the security asset being within a predetermined distance from the camera. More particularly, in one embodiment, the update is performed only when the security asset is within the predetermined distance from the camera.

Abstract: The present disclosure may include: a communication module configured to perform communication with an ultrasonic irradiation device, an ultrasonic imaging device, and a display device; and a processor configured to control an operation in relation to ultrasonic image processing, and the processor is configured to: receive an ultrasonic image from the ultrasonic imaging device through the communication module; extract an irradiation area image for a region of interest (ROI) in the ultrasonic image of the ultrasonic imaging device associated with an ultrasonic irradiation signal of the ultrasonic irradiation device; correct the irradiation area image based on a variation of the ultrasonic irradiation signal in the irradiation area image in a state of focused ultrasound of the ultrasonic irradiation device; and control the display device to display the corrected irradiation area image on the display device.

Abstract: An ultrasonic treatment and monitoring system includes: an ultrasonic treatment device configured to emit ultrasonic waves to treat a patient; an ultrasound image acquisition device configured to obtain an ultrasound image; and a control device. The control device is configured to: determine that the ultrasonic treatment device is on; based on the ultrasonic treatment device being on, control the ultrasound image acquisition device to acquire a first ultrasound image; determine that the ultrasonic treatment device is off; based on the ultrasonic treatment device being off, control the ultrasound image acquisition device to acquire a second ultrasound image; and cause the first ultrasound image and/or the second ultrasound image to be displayed on a display.

Abstract: The present invention provides an alginic acid-based injectable hydrogel system for labeling an accurate position of a disease lesion and effectively delivering a drug to a target region. The formulation of the present invention can make it easy to locally inject a contrast agent and a drug into a target region while controlling the release rate of the contrast agent or the drug, with the formation of the hydrogel in the injected region. Through the advantages, the labeled position can be accurately determined from images, thereby enhancing the precision of surgical operation, with a minimal incision formed therefor. In addition, when used, the alginic acid-based injectable hydrogel system allows the effective local delivery of a drug to a target region while increasing the long-acting effect of the drug.

Abstract: A system includes: a pressure measuring device configured to measure an amount of pressure on a bed; an irradiation device configured to press on a body of a user lying on the bed and to irradiate energy towards the user; and a control device configured to control the irradiation device, wherein the control device is configured to: obtain a pressure measurement from the pressure measuring device; and control the irradiation device to stop an operation of the irradiation device based on the pressure measurement exceeding a preset level.

Abstract: A device for collecting and storing, and dividing a sample. The device includes a hollow cylinder having open top and bottom ends, a top cap which is detachably coupled to the top end of the cylinder so as to block the open top portion of the cylinder, and at which a collection member disposed in the cylinder is mounted, and a bottom cap which is detachably coupled to the bottom end of the cylinder so as to block the open bottom portion of the cylinder, and which stores a reagent in a closed state, wherein the cylinder has, at the inner peripheral surface of the bottom end thereof, an opening part protruding toward the bottom cap so as to open a separation membrane for sealing the reagent.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: Provided is a precursor compound of Formula I used for preparing a cyclic sulfonic acid ester derivative compound, and a method for preparing same, wherein all the variables are described herein.

Abstract: Pyrrolidine carboxamido derivatives, optical isomers thereof, and salts thereof that are able to prevent, improve, and/or treat inflammatory conditions, including inflammatory bowel disease, and methods for preparing and using the same are provided.

Abstract: A method and apparatus for minimizing a time that a camera field of view is not being monitored while the camera is undergoing a software or firmware update is provided herein. During operation a determination is made that a camera needs a software or firmware update. The location of a security asset (e.g., a mobile camera, a security guard, a drone, . . . , etc.) is determined. The update is performed based on the security asset being within a predetermined distance from the camera. More particularly, in one embodiment, the update is performed only when the security asset is within the predetermined distance from the camera.

Abstract: The present invention relates to a fluorine-based polymer coating film, an optical substrate comprising same, and a method for manufacturing the optical substrate, and provides a fluorine-based polymer coating film which is formed from fluorine-based polymer nanoparticles coming in contact and being bound to each other, and which is coated on a substrate to improve infrared transmittance. The fluorine-based polymer coating film according to the present invention has improved infrared transmittance, and since the size of the fluorine-based polymer nanoparticles is controlled to control the ultraviolet-infrared transmittance, transmission wavelength selectivity can be improved.

Abstract: A method for producing a polymer containing metal atoms or halogen atoms at the terminals thereof with excellent efficiency while minimizing or eliminating side reactions or the like is provided. The method can also freely control molecular weight characteristics of the polymer.

Abstract: A laser processing apparatus includes a laser source which generates a laser beam; a scanner unit disposed in an optical path of the laser beam from the laser source and which adjusts the optical path of the laser beam from the laser source in a first direction or in a second direction different from the first direction; and a reflector unit disposed in an optical path of the laser beam adjusted by the scanner unit and which reflects the laser beam adjusted by the scanner unit, where the reflector unit includes a first sub-reflector unit which shifts an optical path of the laser adjusted by the scanner unit in the first direction, and a second sub-reflector unit which shifts an optical path of the laser beam adjusted by the scanner unit in a third direction opposite to the first direction.