Patents by Inventor Soon Ha Kim

Soon Ha Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240374646
    Abstract: The present invention relates to a composition for inhibiting the inflammation or aging of stem cells, comprising, as an active ingredient, a compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof; a method for inhibiting the inflammation or aging of stem cells by using the same; and a method for preparing stem cells having inhibited inflammation or aging; and a pharmaceutical composition for preventing or treating inflammatory diseases, comprising the stem cells, wherein when stem cells are treated with the compound of Chemical Formula 1, the inflammation or aging of stem cells can be inhibited so that the function and morphology of stem cells and intracellular mitochondria damaged in an inflammatory environment can be restored, and the stem cells treated with the compound of Chemical Formula 1 can be effectively used in the prevention or treatment of inflammatory diseases.
    Type: Application
    Filed: April 11, 2022
    Publication date: November 14, 2024
    Inventors: Soon Ha Kim, Jae Ho Lee, Won Dong Yu
  • Publication number: 20240269145
    Abstract: The present invention relates to a use of a compound of Chemical Formula 1, an isomer thereof, a solvate thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof as a ferroptosis inhibitor, and a method of inhibiting ferroptosis using the same. The compound of Chemical Formula 1 according to the present invention may exhibit an effect of inhibiting ferroptosis in various cells such as cardiac, renal, nerve, retinal, hepatic or pulmonary cells, and thus it may be effectively used in preventing or treating a ferroptosis-related disease.
    Type: Application
    Filed: January 25, 2024
    Publication date: August 15, 2024
    Inventors: Soon Ha Kim, Hye Kyung Chang, Mooyoung Seo, Jeong-Hee Yang, Hyunjun Park, Jeong Hyang Park, Yun Min Park, Jin Sung Park, Jae Young Kim, Yewon Yun
  • Publication number: 20240199598
    Abstract: The present invention relates to a sulfate of a compound of chemical formula 1, and a crystalline form thereof. The sulfate of the compound of chemical formula 1, according to the present invention, has much higher solubility than other salts thereof, and exhibits excellent stability and absorption into the body. In addition, such a sulfate can form various crystalline forms, and these crystalline forms are also stable and undergo almost no reduction in purity, even after long-term storage under various conditions, and thus are useful for storage.
    Type: Application
    Filed: April 11, 2022
    Publication date: June 20, 2024
    Inventors: Soon Ha Kim, Sae Yeon Lee, Hyoung Jin Kim, Hye Kyung Chang, Sang Kweon Jeon, Mooyoung Seo
  • Publication number: 20240043409
    Abstract: The present invention relates to a Crystalline Form 1 of a compound of Chemical formula 1 having physically and chemically outstanding characteristics compared to amorphous forms and other crystalline forms of the compound of Chemical Formula 1. Crystalline form A of the compound of Chemical Formula 1 according to the present invention, compared to amorphous forms or other crystalline forms, does not denature even at prolonged exposure to harsh conditions, has low water sorption, is advantageous for formulation as the crystalline form does not change even under pressure or when pulverized, and the crystalline form itself has excellent stability, being useful for storage for extended periods.
    Type: Application
    Filed: April 11, 2022
    Publication date: February 8, 2024
    Inventors: Soon Ha Kim, Hye Kyung Chang, Hyoung Jin Kim, Sae Yeon Lee, Sang Kweon Jeon, Eun Kyung Yoo, Mooyoung Seo
  • Publication number: 20240009202
    Abstract: The present invention relates to a pharmaceutical composition for use in the prevention or treatment of nontuberculous mycobacterium infectious diseases, containing, as an active ingredient, a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof. The compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof, according to the present invention, can be used in the prevention or treatment of nontuberculous mycobacterium (NTM) infectious diseases.
    Type: Application
    Filed: August 18, 2021
    Publication date: January 11, 2024
    Inventors: Soon Ha Kim, Eun Kyeong Jo, Young Jae Kim
  • Patent number: 10927097
    Abstract: The present application relates to an indole compound represented by formula (1): a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: February 23, 2021
    Assignee: LG CHEM, LTD.
    Inventors: Heui Sul Park, Sun Young Koo, Hyoung Jin Kim, Sung Bae Lee, Hyo Shin Kwak, Vasily Artemov, Soon Ha Kim
  • Patent number: 10322135
    Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: June 18, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Heui Sul Park, Seon Yeong Gu, Hyo Shin Kwak, Du Hee Park, Hyo Soo Kim, Hyun Jai Cho, Ji Hyun Kim, Ju Young Kim, Kwang Min Park
  • Patent number: 9868731
    Abstract: The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: January 16, 2018
    Assignee: LG CHEM, LTD.
    Inventors: Heui Sul Park, Sun Young Koo, Hyoung Jin Kim, Sung Bae Lee, Hyo Shin Kwak, Seung Yup Paek, Soon Ha Kim
  • Patent number: 9814726
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating fatty liver diseases, containing (tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof as active ingredients. (Tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof, according to the present invention, can effectively inhibit fatty liver, hepatitis and hepatic fibrosis and can be useful for preventing or treating NAFLD, and in particular, NASH.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 14, 2017
    Assignee: LG CHEM, LTD.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Heui Sul Park, Seo Hyun Ahn, Min Ho Shong, Hyo Kyun Chung
  • Publication number: 20170165272
    Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect
    Type: Application
    Filed: February 24, 2017
    Publication date: June 15, 2017
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Soon Ha KIM, Hyoung Jin KIM, Heui Sul PARK, Seon Yeong GU, Hyo Shin KWAK, Du Hee PARK, Hyo Soo KIM, Hyun Jai CHO, Ji Hyun KIM, Ju Young KIM, Kwang Min PARK
  • Publication number: 20170035776
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating fatty liver diseases, containing (tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof as active ingredients. (Tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof, according to the present invention, can effectively inhibit fatty liver, hepatitis and hepatic fibrosis and can be useful for preventing or treating NAFLD, and in particular, NASH.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 9, 2017
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Soon Ha KIM, Hyoung Jin KIM, Heui Sul PARK, Seo Hyun AHN, Min Ho SHONG, Hyo Kyun CHUNG
  • Publication number: 20160200709
    Abstract: The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
    Type: Application
    Filed: August 21, 2014
    Publication date: July 14, 2016
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Heui Sul PARK, Sun Young KOO, Hyoung Jin KIM, Sung Bae LEE, Hyo Shin KWAK, Vasily ARTEMOV, Soon Ha KIM
  • Publication number: 20160194313
    Abstract: The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
    Type: Application
    Filed: August 21, 2014
    Publication date: July 7, 2016
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Heui Sul PARK, Sun Young KOO, Hyoung Jin KIM, Sung Bae LEE, Hyo Shin KWAK, Seung Yup PAEK, Soon Ha KIM
  • Patent number: 9000028
    Abstract: The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: April 7, 2015
    Assignee: LG Life Sciences Ltd.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Chul Woong Chung, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Hyo Shin Kwak, Dong Ook Seo, Eok Park
  • Patent number: 8889691
    Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: November 18, 2014
    Assignee: LG Life Sciences Ltd.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Seung Yup Paek, Hyo Shin Kwak, Dong Ook Seo, Eok Park
  • Publication number: 20140024618
    Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 23, 2014
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Soon Ha KIM, Hyoung Jin KIM, Sun Young KOO, Sung Bae LEE, Heui Sul PARK, Seung Hyun YOON, Seung Yup PAEK, Hyo Shin KWAK, Dong Ook SEO, Eok PARK
  • Patent number: 8569307
    Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: October 29, 2013
    Assignee: LG Life Sciences Ltd.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Seung Yup Paek, Hyo Shin Kwak, Dong Ook Seo, Eok Park
  • Publication number: 20130237532
    Abstract: The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
    Type: Application
    Filed: April 9, 2013
    Publication date: September 12, 2013
    Applicant: LG Life Sciences Ltd.
    Inventors: Soon Ha KIM, Hyoung Jin KIM, Sun Young KOO, Chul Woong CHUNG, Sung Bae LEE, Heui Sul PARK, Seung Hyun YOON, Hyo Shin KWAK, Dong Ook SEO, Eok PARK
  • Patent number: 8436038
    Abstract: The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: May 7, 2013
    Assignee: LG Life Sciences Ltd.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Chul Woong Chung, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Hyo Shin Kwak, Dong Ook Seo, Eok Park
  • Patent number: 8349885
    Abstract: The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: January 8, 2013
    Assignee: LG Life Sciences Ltd.
    Inventors: Soon Ha Kim, Hyoung Jin Kim, Chul Woong Chung, Heui Sul Park, Hyo Shin Kwak, Sung Ho Kim, Jin Gu Park