Patents by Inventor Soon Ha Kim
Soon Ha Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240374646Abstract: The present invention relates to a composition for inhibiting the inflammation or aging of stem cells, comprising, as an active ingredient, a compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof; a method for inhibiting the inflammation or aging of stem cells by using the same; and a method for preparing stem cells having inhibited inflammation or aging; and a pharmaceutical composition for preventing or treating inflammatory diseases, comprising the stem cells, wherein when stem cells are treated with the compound of Chemical Formula 1, the inflammation or aging of stem cells can be inhibited so that the function and morphology of stem cells and intracellular mitochondria damaged in an inflammatory environment can be restored, and the stem cells treated with the compound of Chemical Formula 1 can be effectively used in the prevention or treatment of inflammatory diseases.Type: ApplicationFiled: April 11, 2022Publication date: November 14, 2024Inventors: Soon Ha Kim, Jae Ho Lee, Won Dong Yu
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Publication number: 20240269145Abstract: The present invention relates to a use of a compound of Chemical Formula 1, an isomer thereof, a solvate thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof as a ferroptosis inhibitor, and a method of inhibiting ferroptosis using the same. The compound of Chemical Formula 1 according to the present invention may exhibit an effect of inhibiting ferroptosis in various cells such as cardiac, renal, nerve, retinal, hepatic or pulmonary cells, and thus it may be effectively used in preventing or treating a ferroptosis-related disease.Type: ApplicationFiled: January 25, 2024Publication date: August 15, 2024Inventors: Soon Ha Kim, Hye Kyung Chang, Mooyoung Seo, Jeong-Hee Yang, Hyunjun Park, Jeong Hyang Park, Yun Min Park, Jin Sung Park, Jae Young Kim, Yewon Yun
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Publication number: 20240199598Abstract: The present invention relates to a sulfate of a compound of chemical formula 1, and a crystalline form thereof. The sulfate of the compound of chemical formula 1, according to the present invention, has much higher solubility than other salts thereof, and exhibits excellent stability and absorption into the body. In addition, such a sulfate can form various crystalline forms, and these crystalline forms are also stable and undergo almost no reduction in purity, even after long-term storage under various conditions, and thus are useful for storage.Type: ApplicationFiled: April 11, 2022Publication date: June 20, 2024Inventors: Soon Ha Kim, Sae Yeon Lee, Hyoung Jin Kim, Hye Kyung Chang, Sang Kweon Jeon, Mooyoung Seo
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Publication number: 20240043409Abstract: The present invention relates to a Crystalline Form 1 of a compound of Chemical formula 1 having physically and chemically outstanding characteristics compared to amorphous forms and other crystalline forms of the compound of Chemical Formula 1. Crystalline form A of the compound of Chemical Formula 1 according to the present invention, compared to amorphous forms or other crystalline forms, does not denature even at prolonged exposure to harsh conditions, has low water sorption, is advantageous for formulation as the crystalline form does not change even under pressure or when pulverized, and the crystalline form itself has excellent stability, being useful for storage for extended periods.Type: ApplicationFiled: April 11, 2022Publication date: February 8, 2024Inventors: Soon Ha Kim, Hye Kyung Chang, Hyoung Jin Kim, Sae Yeon Lee, Sang Kweon Jeon, Eun Kyung Yoo, Mooyoung Seo
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Publication number: 20240009202Abstract: The present invention relates to a pharmaceutical composition for use in the prevention or treatment of nontuberculous mycobacterium infectious diseases, containing, as an active ingredient, a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof. The compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof, according to the present invention, can be used in the prevention or treatment of nontuberculous mycobacterium (NTM) infectious diseases.Type: ApplicationFiled: August 18, 2021Publication date: January 11, 2024Inventors: Soon Ha Kim, Eun Kyeong Jo, Young Jae Kim
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Patent number: 10927097Abstract: The present application relates to an indole compound represented by formula (1): a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.Type: GrantFiled: August 21, 2014Date of Patent: February 23, 2021Assignee: LG CHEM, LTD.Inventors: Heui Sul Park, Sun Young Koo, Hyoung Jin Kim, Sung Bae Lee, Hyo Shin Kwak, Vasily Artemov, Soon Ha Kim
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Patent number: 10322135Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.Type: GrantFiled: February 24, 2017Date of Patent: June 18, 2019Assignee: LG CHEM, LTD.Inventors: Soon Ha Kim, Hyoung Jin Kim, Heui Sul Park, Seon Yeong Gu, Hyo Shin Kwak, Du Hee Park, Hyo Soo Kim, Hyun Jai Cho, Ji Hyun Kim, Ju Young Kim, Kwang Min Park
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Patent number: 9868731Abstract: The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.Type: GrantFiled: August 21, 2014Date of Patent: January 16, 2018Assignee: LG CHEM, LTD.Inventors: Heui Sul Park, Sun Young Koo, Hyoung Jin Kim, Sung Bae Lee, Hyo Shin Kwak, Seung Yup Paek, Soon Ha Kim
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Patent number: 9814726Abstract: The present invention relates to a pharmaceutical composition for preventing or treating fatty liver diseases, containing (tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof as active ingredients. (Tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof, according to the present invention, can effectively inhibit fatty liver, hepatitis and hepatic fibrosis and can be useful for preventing or treating NAFLD, and in particular, NASH.Type: GrantFiled: April 17, 2015Date of Patent: November 14, 2017Assignee: LG CHEM, LTD.Inventors: Soon Ha Kim, Hyoung Jin Kim, Heui Sul Park, Seo Hyun Ahn, Min Ho Shong, Hyo Kyun Chung
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Publication number: 20170165272Abstract: The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effectType: ApplicationFiled: February 24, 2017Publication date: June 15, 2017Applicant: LG LIFE SCIENCES LTD.Inventors: Soon Ha KIM, Hyoung Jin KIM, Heui Sul PARK, Seon Yeong GU, Hyo Shin KWAK, Du Hee PARK, Hyo Soo KIM, Hyun Jai CHO, Ji Hyun KIM, Ju Young KIM, Kwang Min PARK
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Publication number: 20170035776Abstract: The present invention relates to a pharmaceutical composition for preventing or treating fatty liver diseases, containing (tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof as active ingredients. (Tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]amine or a pharmaceutically acceptable salt thereof, according to the present invention, can effectively inhibit fatty liver, hepatitis and hepatic fibrosis and can be useful for preventing or treating NAFLD, and in particular, NASH.Type: ApplicationFiled: April 17, 2015Publication date: February 9, 2017Applicant: LG LIFE SCIENCES LTD.Inventors: Soon Ha KIM, Hyoung Jin KIM, Heui Sul PARK, Seo Hyun AHN, Min Ho SHONG, Hyo Kyun CHUNG
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Publication number: 20160200709Abstract: The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.Type: ApplicationFiled: August 21, 2014Publication date: July 14, 2016Applicant: LG LIFE SCIENCES LTD.Inventors: Heui Sul PARK, Sun Young KOO, Hyoung Jin KIM, Sung Bae LEE, Hyo Shin KWAK, Vasily ARTEMOV, Soon Ha KIM
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Publication number: 20160194313Abstract: The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.Type: ApplicationFiled: August 21, 2014Publication date: July 7, 2016Applicant: LG LIFE SCIENCES LTD.Inventors: Heui Sul PARK, Sun Young KOO, Hyoung Jin KIM, Sung Bae LEE, Hyo Shin KWAK, Seung Yup PAEK, Soon Ha KIM
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Patent number: 9000028Abstract: The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.Type: GrantFiled: April 9, 2013Date of Patent: April 7, 2015Assignee: LG Life Sciences Ltd.Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Chul Woong Chung, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Hyo Shin Kwak, Dong Ook Seo, Eok Park
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Patent number: 8889691Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.Type: GrantFiled: September 23, 2013Date of Patent: November 18, 2014Assignee: LG Life Sciences Ltd.Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Seung Yup Paek, Hyo Shin Kwak, Dong Ook Seo, Eok Park
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Publication number: 20140024618Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.Type: ApplicationFiled: September 23, 2013Publication date: January 23, 2014Applicant: LG LIFE SCIENCES LTD.Inventors: Soon Ha KIM, Hyoung Jin KIM, Sun Young KOO, Sung Bae LEE, Heui Sul PARK, Seung Hyun YOON, Seung Yup PAEK, Hyo Shin KWAK, Dong Ook SEO, Eok PARK
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Patent number: 8569307Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.Type: GrantFiled: June 11, 2012Date of Patent: October 29, 2013Assignee: LG Life Sciences Ltd.Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Seung Yup Paek, Hyo Shin Kwak, Dong Ook Seo, Eok Park
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Publication number: 20130237532Abstract: The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.Type: ApplicationFiled: April 9, 2013Publication date: September 12, 2013Applicant: LG Life Sciences Ltd.Inventors: Soon Ha KIM, Hyoung Jin KIM, Sun Young KOO, Chul Woong CHUNG, Sung Bae LEE, Heui Sul PARK, Seung Hyun YOON, Hyo Shin KWAK, Dong Ook SEO, Eok PARK
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Patent number: 8436038Abstract: The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.Type: GrantFiled: August 18, 2008Date of Patent: May 7, 2013Assignee: LG Life Sciences Ltd.Inventors: Soon Ha Kim, Hyoung Jin Kim, Sun Young Koo, Chul Woong Chung, Sung Bae Lee, Heui Sul Park, Seung Hyun Yoon, Hyo Shin Kwak, Dong Ook Seo, Eok Park
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Patent number: 8349885Abstract: The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.Type: GrantFiled: June 27, 2012Date of Patent: January 8, 2013Assignee: LG Life Sciences Ltd.Inventors: Soon Ha Kim, Hyoung Jin Kim, Chul Woong Chung, Heui Sul Park, Hyo Shin Kwak, Sung Ho Kim, Jin Gu Park