Abstract: The present invention relates to new substituted hydroxyphenylamine based modulators of hormone and/or pigment levels, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Disclosed is a cylindrical lithium secondary battery capable of improving the stability thereof against the external pressure, The cylindrical lithium secondary battery includes an electrode assembly and a core. The electrode assembly includes a first electrode sheet, a second electrode sheet and a separator interposed between the first and second electrode sheets, which are rolled together about an axis. The electrode assembly defines a space. The core has a tubular shape provided with a gap. The core includes at least one reinforcing structure extending in a direction extending along the axis. The core is inserted into the space of the electrode assembly. A housing receives the electrode assembly and core.

Abstract: A cylindrical lithium ion secondary battery includes an electrode assembly; a center pin positioned within the electrode assembly and having upper and lower ends that are closed; a can containing the electrode assembly and the center pin; and a cap assembly coupled to the top of the can. The center pin can include a body extending a predetermined length with its upper and lower end open and at least one closure member adapted to close the upper and lower ends of the body and to melt or fracture at a predetermined temperature. The center pin body may also or altematively include a circuit member positioned inside the center pin and adapted to be short-circuited in the case of overcharging and to consume current.

Abstract: A lithium ion secondary battery including an electrode assembly, a center pin positioned within the electrode assembly, a variable-length member coupled to the center pin, the variable-length member adapted to increase in length when an interior temperature of the center pin reaches a critical temperature, a can containing the electrode assembly, the center pin, and the variable-length member, and a cap assembly coupled to the can, the cap assembly having safety means fracturable in response to the variable-length member being increased in length.

Abstract: A cylindrical lithium secondary battery includes an electrode assembly which has a first electrode plate, a second electrode plate, and a separator provided between the first electrode plate and the second electrode plate, is wound in a spiral shape, and has a central space at the center of winding; a core member which is inserted into the central space of the electrode assembly; a case having a space for containing the electrode assembly; and a cap assembly which is connected to an upper portion of the case so as to seal the case.

Abstract: A jelly-roll electrode assembly includes an extensible fixing layer fixing the shape of the jelly-roll electrode assembly.

Abstract: A lithium rechargeable battery with an electrode assembly comprising at least two positive electrode plates with electrode tabs coupled to each positive electrode plate, at least two negative electrode plates with electrode tabs coupled to each negative electrode plate, separators interposed between each positive and negative electrode pair, and the electrode assembly being formed by winding a layered structure of the electrode plates and separators into a jelly roll shape. The electrode plates are partially coated with electrode active material capable of reversible lithium ion intercalation and de-intercalation. The tabs coupled to the positive electrode plates are coupled with a first terminal of the battery, and the tabs coupled to the negative electrode plates are coupled with a second terminal of the battery.

Abstract: A cylindrical lithium rechargeable battery including a winding type electrode assembly having a first electrode plate, a second electrode plate, and a separator interposed between the first and second electrode plates, a core member arranged in a central space of the electrode assembly and having a short circuit preventing part, a case having a space for accommodating the electrode assembly, and a cap assembly combined with an upper portion of the case to hermetically seal the case.

Abstract: A lithium rechargeable battery includes a current interrupt device in a cap assembly that includes a weakened central breakage portion that is designed to break and interrupt the current in the battery when the pressure inside the battery increases.

Abstract: A secondary battery includes an electrode assembly having first and second electrode plates and a separator interposed between them, a metallic case adapted to contain the electrode assembly, the case provided with an insulation layer, and a cap assembly adapted to complete the case. The insulation layer helps prevent a short circuit between the electrode plates and the case.

Abstract: A cylindrical lithium secondary battery includes a wound electrode assembly having a first electrode plate, a second electrode plate, and a separator interposed between the first electrode plate and the second electrode plate. A core member is substantially in a shape of a pipe and has a cut formed along a longitudinal direction thereof, the cut forming two edges. The core member is inserted into a central space of the electrode assembly and has a predetermined deformation direction when subjected to external pressure. The battery also includes a case with a space for accommodating the electrode assembly and an open upper portion, and a cap assembly fixed to the upper portion of the case to hermetically seal the upper portion of the case.

Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.