Abstract: Reagents that regulate human ceramide kinase protein activity and reagents that bind to human ceramide kinase gene products can be used to regulate intracellular signaling and consequently cell proliferation and apoptosis. Such regulation is particularly useful for treating allergies including but not limited to asthma, autoimmune diseases such as rheumatoid arthritis, inflammatory disease, transplant rejection, and cancer, particularly lymphocytic leukemias, and could be a useful target of vaccination enhancing adjuvants. Central and peripheral nervous system disorders, such as Parkinson's disease, also can be treated.

Abstract: Reagents which regulate human inositol polyphosphate 5-phosphatase and reagents which bind to human inositol polyphosphate 5-phosphatase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, asthma, diabetes, and cancer.

Abstract: Reagents which regulate human inositol polyphosphate 5-phosphatase and reagents which bind to human inositol polyphosphate 5-phosphatase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, asthma, diabetes, and cancer.

Abstract: Reagents that regulate human ceramide kinase protein activity and reagents that bind to human ceramide kinase gene products can be used to regulate intracellular signaling and consequently cell proliferation and apoptosis. Such regulation is particularly useful for treating allergies including but not limited to asthma, autoimmune diseases such as rheumatoid arthritis, inflammatory disease, transplant rejection, and cancer, particularly lymphocytic leukemias, and could be a useful target of vaccination enhancing adjuvants. Central and peripheral nervous system disorders, such as Parkinson's disease, also can be treated.

Abstract: Reagents that regulate human Mut T domain-containing nucleoside diphosphate hydrolase and reagents which bind to human Mut T domain-containing nucleoside diphosphate hydrolase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer.

Abstract: Reagents which regulate human NMDA receptor and reagents which bind to human NMDA receptor gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, Asthma, genito-urinary system disorders including but not limited to urinary incontinence and benign prostate hyperplasia, or peripheral and central nervous system disorders.

Abstract: Reagents which regulate human inositol polyphosphate 5-phosphatase and reagents which bind to human inositol polyphosphate 5-phosphatase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, asthma, diabetes, and cancer.

Abstract: Reagents which regulate human G protein-coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, cancers, anorexia, bulimia, asthma and other allergies, peripheral or central nervous system diseases such as Parkinson's disease, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, diabetes, angina pectoris, myocardial infarction, ulcers, inflammation, and benign prostatic hypertrophy.

Abstract: Reagents which regulate human serine palmitoyltransferase-like enzyme and reagents which bind to human serine palmitoyltransferase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, diabetes, and obesity.

Abstract: Reagents which regulate human secretin receptor-like GPCR and reagents which bind to human secretin-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity and diseases related to obesity, cancer, diabetes, osteoporosis, anxiety, depression, hypertension, migraine, compulsive disorders, schizophrenia, autism, neurodegenerative disorders, such as Alzheimer's disease, Parkinsonism, and Huntington's chorea, and cancer chemotherapy-induced vomiting.

Abstract: Reagents which regulate human phosphatidylinositol-specific phospholipase C-like enzyme and reagents which bind to human phosphatidylinositol-specific phospholipase C-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, peripheral and central nervous system diseases, and chronic obstructive pulmonary disease.

Abstract: The invention relates to genes and proteins of the THAP (THanatos (death)-Associated Protein) family comprising a THAP domain, and their use in diagnostics, treatment of disease, and in the identification of molecules for the treatment of disease. The invention also relates to the Par4 protein and SLC chemokine pathways, including the interaction of Par4 and SLC with THAP family proteins, and the recruitment and localization of Par4 to PML nuclear bodies.

Abstract: Reagents which regulate human sphingosine kinase-like protein activity and reagents which bind to human sphingosine kinase-like gene products can be used to regulate intracellular signaling and consequently cell proliferation and apoptosis. Such regulation is particularly useful for treating cancer, allergies including but not limited to asthma, autoimmune diseases such as rheumatoid arthritis, and central and peripheral nervous system disorders, such as Parkinson's disease.